Targeting PIP4K2 lipid kinases through Thz-P1-2 reveals vulnerabilities related to mitochondrial homeostasis and autophagy in acute leukemia (2022)
- Authors:
- Lima, Keli
- Pereira-Martins Diego A.
- Miranda, Lívia Bassani Lins de
- Coelho-Silva, Juan Luiz
- Leandro, Giovana da Silva
- Isabel Weinhäuser
- Cavaglieri, Rita de Cássia
- Silva, Wellington F.
- Leal, Aline Medeiros
- Lange, Ana Paula Alencar de Lima
- Velloso, Elvira Deolinda Rodrigues Pereira
- Griessinger, Emmanuel
- Hilberink, Jacobien R.
- Huls, Gerwin A.
- Schuringa, Jan Jacob
- Rego, Eduardo M.
- Machado Neto, João Agostinho
- Lima, Keli
- USP affiliated authors: VELLOSO, ELVIRA DEOLINDA RODRIGUES PEREIRA - FM ; MACHADO NETO, JOÃO AGOSTINHO - ICB ; REGO, EDUARDO MAGALHÃES - FM ; LIMA, KELI CRISTINA DE - FM ; MIRANDA, LÍVIA BASSANI LINS DE - ICB ; MARTINS, DIEGO ANTONIO PEREIRA - FMRP ; SILVA, JUAN LUIZ COELHO DA - FMRP ; WEINHÄUSER, ISABEL - FMRP
- Unidades: FM; ICB; FMRP
- DOI: 10.1182/blood-2022-165172
- Subjects: FARMACOLOGIA; LEUCEMIA MIELOIDE AGUDA; NEOPLASIAS POR TIPO HISTOLÓGICO; AMINOÁCIDOS; PROTEÍNAS QUINASES; DANO AO DNA; MITOCÔNDRIAS; HOMEOSTASE; LISOSSOMOS
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher place: Washington
- Date published: 2022
- Source:
- Este periódico é de assinatura
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: bronze
-
ABNT
LIMA, Keli et al. Targeting PIP4K2 lipid kinases through Thz-P1-2 reveals vulnerabilities related to mitochondrial homeostasis and autophagy in acute leukemia. Blood, v. 140, p. 5965–5966, 2022Tradução . . Disponível em: https://doi.org/10.1182/blood-2022-165172. Acesso em: 26 dez. 2025. -
APA
Lima, K., Pereira-Martins Diego A.,, Miranda, L. B. L. de, Coelho-Silva, J. L., Leandro, G. da S., Isabel Weinhäuser,, et al. (2022). Targeting PIP4K2 lipid kinases through Thz-P1-2 reveals vulnerabilities related to mitochondrial homeostasis and autophagy in acute leukemia. Blood, 140, 5965–5966. doi:10.1182/blood-2022-165172 -
NLM
Lima K, Pereira-Martins Diego A., Miranda LBL de, Coelho-Silva JL, Leandro G da S, Isabel Weinhäuser, Cavaglieri R de C, Silva WF, Leal AM, Lange APA de L, Velloso EDRP, Griessinger E, Hilberink JR, Huls GA, Schuringa JJ, Rego EM, Machado Neto JA. Targeting PIP4K2 lipid kinases through Thz-P1-2 reveals vulnerabilities related to mitochondrial homeostasis and autophagy in acute leukemia [Internet]. Blood. 2022 ; 140 5965–5966.[citado 2025 dez. 26 ] Available from: https://doi.org/10.1182/blood-2022-165172 -
Vancouver
Lima K, Pereira-Martins Diego A., Miranda LBL de, Coelho-Silva JL, Leandro G da S, Isabel Weinhäuser, Cavaglieri R de C, Silva WF, Leal AM, Lange APA de L, Velloso EDRP, Griessinger E, Hilberink JR, Huls GA, Schuringa JJ, Rego EM, Machado Neto JA. Targeting PIP4K2 lipid kinases through Thz-P1-2 reveals vulnerabilities related to mitochondrial homeostasis and autophagy in acute leukemia [Internet]. Blood. 2022 ; 140 5965–5966.[citado 2025 dez. 26 ] Available from: https://doi.org/10.1182/blood-2022-165172 - The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy
- Pharmacological PIP4K2 inhibition disrupts mitochondrial homeostasis and autophagy in acute leukemia
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Informações sobre o DOI: 10.1182/blood-2022-165172 (Fonte: oaDOI API)
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