Tese

Clinical relevance of oxidative stress biomarkers in cardiovascular prevention (2022)

• Authors:
  • Pimentel, Mariana Vieira de Mello Barros
  • Castro, Inar Alves de (Orientador)
• Autor USP: PIMENTEL, MARIANA VIEIRA DE MELLO BARROS - FCF
• Unidade: FCF
• Sigla do Departamento: FBA
• DOI: 10.11606/D.9.2022.tde-15022023-135127
• Subjects: ESTRESSE OXIDATIVO; BIOMARCADORES; ARTERIOSCLEROSE
• Keywords: Aterosclerose; Atherosclerosis; Biomarcadores; Biomarker; Estratificação de risco; Estresse oxidativo; Oxidative stress; Risk stratification
• Agências de fomento:
  • Financiamento CAPES
• Language: Inglês
• Abstract: Cardiovascular diseases involve hyperlipidemia, inflammation and oxidative stress. Although this relationship is well established, only biomarkers associated with hyperlipidemia and inflammation are currently in clinical practice for diagnosis and evaluation of patient treatment. Our hypothesis is that oxidative stress biomarkers may be an independent risk factor and may assist in cardiovascular risk stratification and contribute to improving current scores. Thus, the objective of this study was to investigate which are the biomarkers and methodologies were used in clinical studies in humans with different health conditions. With the results obtained in the first part, we selected studies conducted in healthy individuals and in individuals under primary and secondary cardiovascular prevention in order to evaluate the most frequent biomarkers, the results obtained according to the individual's profile and the methodology used, and correlate with different health conditions. We observed that malondialdehyde (MDA) was the most frequent lipid biomarker of oxidative stress applied in the studies, but it presented significant variability in the results and a weak correlation with clinical outcomes. The result of this study demonstrates the importance of carrying out a multicentric study to validate the MDA values in individuals with different health conditions and the standardization of the methodology based on high performance liquid chromatographyy (HPLC)
• Imprenta:
  • Publisher place: São Paulo
  • Date published: 2022
• Data da defesa: 16.12.2022

Informações sobre o DOI: 10.11606/D.9.2022.tde-15022023-135127 (Fonte: oaDOI API)
• Este periódico é de acesso aberto
• Este artigo é de acesso aberto
• URL de acesso aberto
• Cor do Acesso Aberto: gold
• Licença: cc-by-nc-sa

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How to cite

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• ABNT

  PIMENTEL, Mariana Vieira de Mello Barros. Clinical relevance of oxidative stress biomarkers in cardiovascular prevention. 2022. Dissertação (Mestrado) – Universidade de São Paulo, São Paulo, 2022. Disponível em: https://www.teses.usp.br/teses/disponiveis/9/9132/tde-15022023-135127/. Acesso em: 31 dez. 2025.

• APA

  Pimentel, M. V. de M. B. (2022). Clinical relevance of oxidative stress biomarkers in cardiovascular prevention (Dissertação (Mestrado). Universidade de São Paulo, São Paulo. Recuperado de https://www.teses.usp.br/teses/disponiveis/9/9132/tde-15022023-135127/

• NLM

  Pimentel MV de MB. Clinical relevance of oxidative stress biomarkers in cardiovascular prevention [Internet]. 2022 ;[citado 2025 dez. 31 ] Available from: https://www.teses.usp.br/teses/disponiveis/9/9132/tde-15022023-135127/

• Vancouver

  Pimentel MV de MB. Clinical relevance of oxidative stress biomarkers in cardiovascular prevention [Internet]. 2022 ;[citado 2025 dez. 31 ] Available from: https://www.teses.usp.br/teses/disponiveis/9/9132/tde-15022023-135127/

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