Caracterização do metaboloma sérico de gatos com doença renal crônica (2022)
- Authors:
- USP affiliated authors: VENDRAMINI, THIAGO HENRIQUE ANNIBALE - FMVZ ; BRUNETTO, MARCIO ANTONIO - FMVZ ; MACHADO, DANIELA PEDROSA - FMVZ ; TEIXEIRA, FÁBIO ALVES - FMVZ
- Unidade: FMVZ
- Subjects: GATOS; NEFROPATIAS EM ANIMAL; METABOLÔMICA; ALIMENTOS PARA ANIMAIS
- Keywords: felines; metabolic profile; nutrition; renal disease; uremic toxins
- Language: Português
- Abstract: Chronic kidney disease (CKD) is a highly prevalent ailment in domestic cats. The search for precise and timely diagnosis of CKD has resulted in new ways of inquiry. Renal diets have been recommended as supporting treatment. The aims of this study are to define the serum metabolomic of healthy and CKD stages 1 and 2 cats, to better understand the metabolic patterns present in each phase of the disease, and to compare the serum metabolomic profile of these cats before and after a period of introduction of a renal diet. Twenty-five cats divided into three groups (control, CKD1, and CKD2) had their serum metabolomics assessed in T0 and T60 by mass spectrometry/gas chromatography. Discriminant analysis and principal component analysis were performed to assess differences in metabolomic profiles between groups and before and after renal diet. Citric acid and monostearin were the metabolites that had significant values in T0. A total of 7 serum metabolites significantly differed after consumption of the renal diet compared with the maintenance diet; some of them have the potential for use as possible early diagnostic biomarkers of chronic kidney disease.
- Imprenta:
- Publisher: CBNA - Colégio Brasileiro de Nutrição Animal
- Publisher place: [Campinas]
- Date published: 2022
- Source:
- Título do periódico: Anais
- Conference titles: Workshop Sobre Nutrição e Nutrologia de Cães e Gatos
-
ABNT
MACHADO, Daniela Pedrosa et al. Caracterização do metaboloma sérico de gatos com doença renal crônica. 2022, Anais.. [Campinas]: CBNA - Colégio Brasileiro de Nutrição Animal, 2022. . Acesso em: 19 abr. 2024. -
APA
Machado, D. P., Pontieri, C. F. F., Jeremias, J. T., Teixeira, F. A., Vendramini, T. H. A., & Brunetto, M. A. (2022). Caracterização do metaboloma sérico de gatos com doença renal crônica. In Anais. [Campinas]: CBNA - Colégio Brasileiro de Nutrição Animal. -
NLM
Machado DP, Pontieri CFF, Jeremias JT, Teixeira FA, Vendramini THA, Brunetto MA. Caracterização do metaboloma sérico de gatos com doença renal crônica. Anais. 2022 ;[citado 2024 abr. 19 ] -
Vancouver
Machado DP, Pontieri CFF, Jeremias JT, Teixeira FA, Vendramini THA, Brunetto MA. Caracterização do metaboloma sérico de gatos com doença renal crônica. Anais. 2022 ;[citado 2024 abr. 19 ] - Starch sources influence lipidaemia of diabetic dogs
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