Artigo de periodico

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths (2021)

• Authors:
  • Bastard, Paul
  • Gervais, Adrian
  • Voyer, Tom Le
  • Rosain, Jérémie
  • Philippot, Quentin
  • Manry, Jérémy
  • Michailidis, Eleftherios
  • Hoffmann, Hans-Heinrich
  • Eto, Shohei
  • Garcia-Prat, Marina
  • Bizien, Lucy
  • Parra-Martínez, Alba
  • Yang, Rui
  • Liis, Haljasmägi
  • Migaud, Mélanie
  • Särekannu, Karita
  • Maslovskaja, Julia
  • Prost, Nicolas de
  • Tandjaoui-Lambiotte, Yacine
  • Luyt , Charles-Edouard
  • Amador-Borrero, Blanca
  • Alexandre, Gaudet
  • Poissy, Julien
  • Morel, Pascal
  • Richard, Pascale
  • Cognasse, Fabrice
  • Troya, Jesus
  • Trouillet-Assant, Sophie
  • Belot, Alexandre
  • Saker, Kahina
  • Garçon, Pierre
  • Rivière, Jacques G
  • Lagier, Jean-Christophe
  • Gentile, Stéphanie
  • Rosen, Lindsey B
  • Shaw, Elana
  • Morio, Tomohiro
  • Tanaka, Junko
  • Dalmau, David
  • Tharaux, Pierre-Louis
  • Sene, Damien
  • Stepanian, Alain
  • Megarbane, Bruno
  • Triantafyllia, Vasiliki
  • Fekkar, Arnaud
  • Heath, James R
  • Franco, José Luis
  • Anaya, Juan-Manuel
  • Solé-Violán, Jordi
  • Imberti, Luisa
  • Biondi, Andrea
  • Bonfanti, Paolo
  • Castagnoli, Riccardo
  • Delmonte, Ottavia M
  • Zhang, Yu
  • Snow, Andrew L
  • Holland, Steven M
  • Biggs, Catherine M
  • Moncada-Vélez, Marcela
  • Arias, Andrés Augusto
  • Lorenzo, Lazaro
  • Boucherit, Soraya
  • Coulibaly, Boubacar
  • Anglicheau, Dany
  • Planas, Anna M
  • Haerynck, Filomeen
  • Duvlis, Sotirija
  • Nussbaum, Robert L
  • Ozcelik, Tayfun
  • Keles, Sevgi
  • Bousfiha, Ahmed A
  • ElBakkouri, Jalila
  • Ramirez-Santana, Carolina
  • Paul, Stéphane
  • Pan-Hammarström, Qiang
  • Hammarström, Lennart
  • Dupont, Annabelle
  • Kurolap, Alina
  • Metz, Christine N
  • Aiuti, Alessandro
  • Casari, Giorgio
  • Lampasona, Vito
  • Ciceri, Fabio
  • Barreiros, Lucila A
  • Dominguez-Garrido, Elena
  • Vidigal, Mateus
  • Zatz, Mayana
  • Beek, Diederik van de
  • Sahanic, Sabina
  • Tancevski, Ivan
  • Stepanovskyy, Yurii
  • Boyarchuk, Oksana
  • Nukui, Yoko
  • Tsumura, Miyuki
  • Vidaur, Loreto
  • Tangye, Stuart G
  • Burrel, Sonia
  • Duffy, Darragh
  • Quintana-Murci, Lluis
  • Klocperk, Adam
  • Kann, Nelli Y
  • Shcherbina, Anna
  • Lau, Yu-Lung
  • Leung, Daniel
  • Coulongeat, Matthieu
  • Marlet, Julien
  • Koning, Rutger
  • Reyes, Luis Felipe
  • Chauvineau-Grenier, Angélique
  • Vene, Fabienne
  • Monneret, Guillaume
  • Nussenzweig, Michel C
  • Arrestier, Romain
  • Boudhabhay, Idris
  • Baris-Feldman, Hagit
  • Hagin, David
  • Wauters, Joost
  • Meyts, Isabelle
  • Dyer, Adam H
  • Kennelly, Sean P
  • Bourke, Nollaig M
  • Halwani, Rabih
  • Sharif-Askari, Narjes Saheb
  • Dorgham, Karim
  • Sallette, Jérome
  • Sedkaoui, Souad Mehlal
  • AlKhater, Suzan
  • Rigo-Bonnin, Raúl
  • Morandeira, Francisco
  • Roussel, Lucie
  • Vinh, Donald C
  • Ostrowski, Sisse Rye
  • Condino Neto, Antonio
  • Prando, Carolina
  • Bondarenko, Anastasiia
  • Spaan, András N
  • Gilardin, Laurent
  • Fellay, Jacques
  • Lyonnet, Stanislas
  • Bilguvar, Kaya
  • Lifton, Richard P
  • Mane, Shrikant
  • Anderson, Mark S
  • Boisson, Bertrand
  • Béziat, Vivien
  • Zhang, Shen-Ying
  • Andreakos, Evangelos
  • Hermine, Olivier
  • Pujol, Aurora
  • Peterson, Pärt
  • Mogensen, Trine
  • H Rowen, Lee
  • Mond, James
  • Debette, Stéphanie
  • Lamballerie, Xavier de
  • Duval, Xavier
  • Mentré, France
  • Zins, Marie
  • Soler-Palacin, Pere
  • Colobran, Roger
  • Gorochov, Guy
  • Solanich, Xavier
  • Susen, Sophie
  • Martinez-Picado, Javier
  • Raoult, Didier
  • Vasse, Marc
  • Gregersen, Peter K
  • Piemonti, Lorenzo
  • Rodríguez-Gallego, Carlos
  • Notarangelo, Luigi D
  • Su, Helen C
  • Kisand, Kai
  • Okada, Satoshi
  • Puel, Anne
  • Jouanguy, Emmanuelle
  • Rice, Charles M
  • Tiberghien, Pierre
  • Zhang, Qian
  • Cobat, Aurélie
  • Abel, Laurent
  • Casanova, Jean-Laurent
• USP affiliated authors: ZATZ, MAYANA - IB ; CONDINO NETO, ANTONIO - ICB ; BARREIROS, LUCILA AKUNE - IB ; CASTRO, MATEUS VIDIGAL DE - IB
• Unidades: IB; ICB
• DOI: 10.1126/sciimmunol.abl4340
• Subjects: COVID-19; INFECÇÕES POR CORONAVIRUS; ANTICORPOS; IMUNOLOGIA; HOMENS
• Agências de fomento:
  • Financiamento FAPESP
  • Financiamento NHGRI/CRGGH/NIH
  • Financiamento National Center for Advancing Translational Sciences
  • Financiamento ANR
  • Financiamento NEI/NIH
  • Financiamento DIR/NIAID/NIH
  • Financiamento ISCIII
  • Financiamento AMED
  • Financiamento NCI
  • Financiamento JBS S.A.
• Language: Inglês
• Imprenta:
  • Publisher place: Washington
  • Date published: 2021
• Source:
  • Título: Science Immunology
  • ISSN: 2470-9468
  • Volume/Número/Paginação/Ano: v. 6, n. 62, p. 1-30, 2021


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• ABNT

  BASTARD, Paul et al. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Science Immunology, v. 6, n. 62, p. 1-30, 2021Tradução . . Disponível em: https://doi.org/10.1126/sciimmunol.abl4340. Acesso em: 31 mar. 2026.

• APA

  Bastard, P., Gervais, A., Voyer, T. L., Rosain, J., Philippot, Q., Manry, J., et al. (2021). Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Science Immunology, 6( 62), 1-30. doi:10.1126/sciimmunol.abl4340

• NLM

  Bastard P, Gervais A, Voyer TL, Rosain J, Philippot Q, Manry J, Michailidis E, Hoffmann H-H, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Liis H, Migaud M, Särekannu K, Maslovskaja J, Prost N de, Tandjaoui-Lambiotte Y, Luyt C-E, Amador-Borrero B, Alexandre G, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier J-C, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux P-L, Sene D, Stepanian A, Megarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya J-M, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs CM, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Coulibaly B, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Nussbaum RL, Ozcelik T, Keles S, Bousfiha AA, ElBakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, Beek D van de, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann NY, Shcherbina A, Lau Y-L, Leung D, Coulongeat M, Marlet J, Koning R, Reyes LF, Chauvineau-Grenier A, Vene F, Monneret G, Nussenzweig MC, Arrestier R, Boudhabhay I, Baris-Feldman H, Hagin D, Wauters J, Meyts I, Dyer AH, Kennelly SP, Bourke NM, Halwani R, Sharif-Askari NS, Dorgham K, Sallette J, Sedkaoui SM, AlKhater S, Rigo-Bonnin R, Morandeira F, Roussel L, Vinh DC, Ostrowski SR, Condino Neto A, Prando C, Bondarenko A, Spaan AN, Gilardin L, Fellay J, Lyonnet S, Bilguvar K, Lifton RP, Mane S, Anderson MS, Boisson B, Béziat V, Zhang S-Y, Andreakos E, Hermine O, Pujol A, Peterson P, Mogensen T, H Rowen L, Mond J, Debette S, Lamballerie X de, Duval X, Mentré F, Zins M, Soler-Palacin P, Colobran R, Gorochov G, Solanich X, Susen S, Martinez-Picado J, Raoult D, Vasse M, Gregersen PK, Piemonti L, Rodríguez-Gallego C, Notarangelo LD, Su HC, Kisand K, Okada S, Puel A, Jouanguy E, Rice CM, Tiberghien P, Zhang Q, Cobat A, Abel L, Casanova J-L. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths [Internet]. Science Immunology. 2021 ; 6( 62): 1-30.[citado 2026 mar. 31 ] Available from: https://doi.org/10.1126/sciimmunol.abl4340

• Vancouver

  Bastard P, Gervais A, Voyer TL, Rosain J, Philippot Q, Manry J, Michailidis E, Hoffmann H-H, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Liis H, Migaud M, Särekannu K, Maslovskaja J, Prost N de, Tandjaoui-Lambiotte Y, Luyt C-E, Amador-Borrero B, Alexandre G, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier J-C, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux P-L, Sene D, Stepanian A, Megarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya J-M, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs CM, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Coulibaly B, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Nussbaum RL, Ozcelik T, Keles S, Bousfiha AA, ElBakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, Beek D van de, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann NY, Shcherbina A, Lau Y-L, Leung D, Coulongeat M, Marlet J, Koning R, Reyes LF, Chauvineau-Grenier A, Vene F, Monneret G, Nussenzweig MC, Arrestier R, Boudhabhay I, Baris-Feldman H, Hagin D, Wauters J, Meyts I, Dyer AH, Kennelly SP, Bourke NM, Halwani R, Sharif-Askari NS, Dorgham K, Sallette J, Sedkaoui SM, AlKhater S, Rigo-Bonnin R, Morandeira F, Roussel L, Vinh DC, Ostrowski SR, Condino Neto A, Prando C, Bondarenko A, Spaan AN, Gilardin L, Fellay J, Lyonnet S, Bilguvar K, Lifton RP, Mane S, Anderson MS, Boisson B, Béziat V, Zhang S-Y, Andreakos E, Hermine O, Pujol A, Peterson P, Mogensen T, H Rowen L, Mond J, Debette S, Lamballerie X de, Duval X, Mentré F, Zins M, Soler-Palacin P, Colobran R, Gorochov G, Solanich X, Susen S, Martinez-Picado J, Raoult D, Vasse M, Gregersen PK, Piemonti L, Rodríguez-Gallego C, Notarangelo LD, Su HC, Kisand K, Okada S, Puel A, Jouanguy E, Rice CM, Tiberghien P, Zhang Q, Cobat A, Abel L, Casanova J-L. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths [Internet]. Science Immunology. 2021 ; 6( 62): 1-30.[citado 2026 mar. 31 ] Available from: https://doi.org/10.1126/sciimmunol.abl4340

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