Focus on Vitamin D, Inflammation and Type 2 Diabetes (2012)
- Authors:
- USP affiliated authors: ROGERO, MARCELO MACEDO - FSP ; CAVALHEIRO, LIGIA ARAUJO MARTINI - FSP ; BORGES, MARIA CAROLINA - FSP
- Unidade: FSP
- DOI: 10.3390/nu4010052
- Subjects: VITAMINA D; INFLAMAÇÃO; DIABETES MELLITUS INSULINO-DEPENDENTE
- Agências de fomento:
- Language: Inglês
- Abstract: The initial observations linking vitamin D to type 2 diabetes in humans came from studies showing that both healthy and diabetic subjects had a seasonal variation of glycemic control. Currently, there is evidence supporting that vitamin D status is important to regulate some pathways related to type 2 diabetes development. Since the activation of inflammatory pathways interferes with normal metabolism and disrupts proper insulin signaling, it is hypothesized that vitamin D could influence glucose homeostasis by modulating inflammatory response. Human studies investigating the impact of vitamin D supplementation on inflammatory biomarkers of subjects with or at high risk of developing type 2 diabetes are scarce and have generated conflicting results. Based on available clinical and epidemiological data, the positive effects of vitamin D seem to be primarily related to its action on insulin secretion and sensitivity and secondary to its action on inflammation. Future studies specifically designed to investigate the role of vitamin D on type 2 diabetes using inflammation as the main outcome are urgently needed in order to provide a more robust link between vitamin D, inflammation and type 2 diabetes
- Imprenta:
- Source:
- Status:
- Artigo publicado em periódico de acesso aberto (Gold Open Access)
- Versão do Documento:
- Versão publicada (Published version)
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ABNT
CHAGAS, Carlos Eduardo Andrade et al. Focus on Vitamin D, Inflammation and Type 2 Diabetes. Nutrients, v. 4, n. 1, p. 52-67, 2012Tradução . . Disponível em: https://doi.org/10.3390/nu4010052. Acesso em: 01 abr. 2026. -
APA
Chagas, C. E. A., Borges, M. C., Martini, L. A., Rogero, M. M., & Rogero, M. M. (2012). Focus on Vitamin D, Inflammation and Type 2 Diabetes. Nutrients, 4( 1), 52-67. doi:10.3390/nu4010052 -
NLM
Chagas CEA, Borges MC, Martini LA, Rogero MM, Rogero MM. Focus on Vitamin D, Inflammation and Type 2 Diabetes [Internet]. Nutrients. 2012 ;4( 1): 52-67.[citado 2026 abr. 01 ] Available from: https://doi.org/10.3390/nu4010052 -
Vancouver
Chagas CEA, Borges MC, Martini LA, Rogero MM, Rogero MM. Focus on Vitamin D, Inflammation and Type 2 Diabetes [Internet]. Nutrients. 2012 ;4( 1): 52-67.[citado 2026 abr. 01 ] Available from: https://doi.org/10.3390/nu4010052 - Current perspectives on vitamin D, immune system, and chronic diseases
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