DNA methylation and one-carbon metabolism related nutrients and polymorphisms: analysis after mandatory flour fortification with folic acid (2020)
- Authors:
- USP affiliated authors: FISBERG, REGINA MARA - FSP ; MARCHIONI, DIRCE MARIA LOBO - FSP ; STELUTI, JOSIANE - FSP ; MIRANDA, ANDREIA ALEXANDRA MACHADO - FSP ; PALCHETTI, CECILIA ZANIN - FSP
- Unidade: FSP
- DOI: 10.1017/S0007114519002526
- Subjects: ÁCIDO FÓLICO; ALIMENTOS FORTIFICADOS; METILAÇÃO; DNA; CARBONO
- Agências de fomento:
- Language: Inglês
- Abstract: There is a growing research interest in determining whether changes in the Global status of DNA methylation are related to the environment, in particular, to one-carbon metabolism. So, our aim was to investigate the effect of dietary methyl-group donor intake (methionine, folate, choline, betaine, vitamins B2, B6, and B12), biomarkers (total folate, UMFA, 5-methylTHF, hcy, vitamins B6 and B12 concentrations) and genetic variants (polymorphisms involved in one-carbon metabolism) on Global DNA methylation in a population exposed to mandatory flour fortification with folic acid. A cross-sectional study of health and living conditions was conducted among a representative sample of residents in São Paulo-Brazil. The mean of Global DNA methylation was lower in young people than in adults and the elderly (p=0.049). No differences between genotypes of polymorphism and Global DNA methylation mean were identified. We observed that the increase in betaine intake led to an absolute change in percentage of DNA methylation (β=0.0005, p=0.024) using multiple regression. Betaine intake alone was associated with an absolute change in percentage of Global DNA methylation. The study did not find an association between Global DNA methylation and folate status even in a population exposed to mandatory flour fortification with folic acid.
- Imprenta:
- Publisher place: Wallingford
- Date published: 2020
- Source:
- Título do periódico: British Journal of Nutrition
- ISSN: 1475-2662
- Volume/Número/Paginação/Ano: v.123, n.1, p. 23-29, 2020
- Este periódico é de assinatura
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: bronze
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ABNT
STELUTI, Josiane et al. DNA methylation and one-carbon metabolism related nutrients and polymorphisms: analysis after mandatory flour fortification with folic acid. British Journal of Nutrition, v. 123, n. 1, p. 23-29, 2020Tradução . . Disponível em: https://doi.org/10.1017/S0007114519002526. Acesso em: 28 set. 2024. -
APA
Steluti, J., Palchetti, C. Z., Miranda, A. M., Fisberg, R. M., & Marchioni, D. M. L. (2020). DNA methylation and one-carbon metabolism related nutrients and polymorphisms: analysis after mandatory flour fortification with folic acid. British Journal of Nutrition, 123( 1), 23-29. doi:10.1017/S0007114519002526 -
NLM
Steluti J, Palchetti CZ, Miranda AM, Fisberg RM, Marchioni DML. DNA methylation and one-carbon metabolism related nutrients and polymorphisms: analysis after mandatory flour fortification with folic acid [Internet]. British Journal of Nutrition. 2020 ;123( 1): 23-29.[citado 2024 set. 28 ] Available from: https://doi.org/10.1017/S0007114519002526 -
Vancouver
Steluti J, Palchetti CZ, Miranda AM, Fisberg RM, Marchioni DML. DNA methylation and one-carbon metabolism related nutrients and polymorphisms: analysis after mandatory flour fortification with folic acid [Internet]. British Journal of Nutrition. 2020 ;123( 1): 23-29.[citado 2024 set. 28 ] Available from: https://doi.org/10.1017/S0007114519002526 - Unmetabolized folic acid is associated with TNF‑α, IL‑1β and IL‑12 concentrations in a population exposed to mandatory food fortification with folic acid: a cross-sectional population-based study in Sao Paulo, Brazil
- Unmetabolized folic acid is associated with TNF-α, IL-1β and IL-12 concentrations in a population exposed to mandatory food fortification with folic acid: cross-sectional population-based study in Sao Paulo, Brazil
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Informações sobre o DOI: 10.1017/S0007114519002526 (Fonte: oaDOI API)
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