Artigo de periodico

Cord blood concentrations of leptin, zinc-α2-glycoprotein and adiponectin, and adiposity gain in the first three months of life (2018)

• Authors:
  • Euclydes, Veronica Luiza Vale
  • Castro, Natália Pinheiro de
  • Lima, Lourdes R
  • Brito, Cyro
  • Ribeiro, Laisa
  • Simões, Fernanda Agapito
  • Requena, Guaraci de Lima
  • Luzia, Liania Alves
  • Rondó, Patricia Helen de Carvalho
• USP affiliated authors: LUZIA, LIANIA ALVES - FSP ; RONDO, PATRICIA HELEN DE CARVALHO - FSP ; CASTRO, NATÁLIA PINHEIRO DE - FCF ; REQUENA, GUARACI DE LIMA - IME
• Unidades: FSP; FCF; IME
• DOI: 10.1016/j.nut.2018.02.012
• Subjects: LACTENTES; LEPTINA; ZINCO; ADIPONECTINA; GLICOPROTEÍNAS
• Agências de fomento:
  • Financiado pela FAPESP
• Language: Inglês
• Abstract: Objectives:Adipose tissue development starts in intrauterine life and cytokines are involved in this process.Therefore, understanding the role of cytokines in the fat mass gain of infants is crucial to prevent obesitylater in life. Furthermore, recent evidence indicates a sex-specific link between cytokines and adiposetissue development. The objective of this study was to assess sex-specific relationships of cord blood con-centrations of the cytokines leptin, zinc-α2-glycoprotein (ZAG), and adiponectin with infant adiposityduring the first 3 mo of life.Methods:This was a prospective cohort study of 104 mother-infant pairs that were selected from a ma-ternity hospital in Sao Paulo, Brazil. Cord blood leptin, ZAG, and adiponectin were determined by enzyme-linked immunosorbent assays. The body composition of the infants was assessed monthly by airdisplacement plethysmography. A multiple linear regression analysis was conducted with the averagefat mass gain from birth to the third month of life as the outcome and cord blood leptin, ZAG, andadiponectin as the variables of interest.Results:Leptin was inversely associated with fat mass gain in the first 3 mo of life (P=0.003; adjustedR2=0.09). There were inverse associations of leptin (P=0.021), ZAG (P=0.042), and maternal body massindex (P=0.04) with fat mass gain in girls (adjusted R2=0.29) but fat mass gain in boys was positivelyassociated with gestational age (P=0.01; adjusted R2=0.15).Conclusions:The results of this study suggest that adiposity programming is sex-specific, which high-lights the need to investigate the different metabolic mechanisms that are involved in adipogenesis
• Imprenta:
  • Publisher place: Tarrytown
  • Date published: 2018
• Source:
  • Título: Nutrition
  • ISSN: 0899-9007
  • Volume/Número/Paginação/Ano: v. 54, p. 89-93, 2018

Informações sobre o DOI: 10.1016/j.nut.2018.02.012 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

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• ABNT

  EUCLYDES, Veronica Luiza Vale et al. Cord blood concentrations of leptin, zinc-α2-glycoprotein and adiponectin, and adiposity gain in the first three months of life. Nutrition, v. 54, p. 89-93, 2018Tradução . . Disponível em: https://doi.org/10.1016/j.nut.2018.02.012. Acesso em: 28 dez. 2025.

• APA

  Euclydes, V. L. V., Castro, N. P. de, Lima, L. R., Brito, C., Ribeiro, L., Simões, F. A., et al. (2018). Cord blood concentrations of leptin, zinc-α2-glycoprotein and adiponectin, and adiposity gain in the first three months of life. Nutrition, 54, 89-93. doi:10.1016/j.nut.2018.02.012

• NLM

  Euclydes VLV, Castro NP de, Lima LR, Brito C, Ribeiro L, Simões FA, Requena G de L, Luzia LA, Rondó PH de C. Cord blood concentrations of leptin, zinc-α2-glycoprotein and adiponectin, and adiposity gain in the first three months of life [Internet]. Nutrition. 2018 ; 54 89-93.[citado 2025 dez. 28 ] Available from: https://doi.org/10.1016/j.nut.2018.02.012

• Vancouver

  Euclydes VLV, Castro NP de, Lima LR, Brito C, Ribeiro L, Simões FA, Requena G de L, Luzia LA, Rondó PH de C. Cord blood concentrations of leptin, zinc-α2-glycoprotein and adiponectin, and adiposity gain in the first three months of life [Internet]. Nutrition. 2018 ; 54 89-93.[citado 2025 dez. 28 ] Available from: https://doi.org/10.1016/j.nut.2018.02.012

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