Dietary phylloquinone depletion and repletion in older women (2003)
- Authors:
- Autor USP: MARTINI, LIGIA ARAUJO - FSP
- Unidade: FSP
- Subjects: VITAMINA K (DEFICIÊNCIA); PROTEÍNAS SANGUÍNEAS (ANÁLISE); COAGULAÇÃO; PROTEÍNAS DE LIGAÇÃO DO CÁLCIO; INGESTÃO; BIOMARCADORES
- Language: Inglês
- Abstract: Biological markers indicative of poor vitamin K status have been associated with a greater risk for hip fracture in older men and women. However, the dietary phylloquinone intake required to achieve maximal carboxylation of hepatic and extrahepatic vitamin K-dependent proteins is not known. In an 84-d study in a metabolic unit, 21 older (60-80 y) women were fed a phylloquinone-restricted diet (18 µg/d) for 28 d, followed by stepwise repletion of 86, 200 and 450 µg/d of phylloquinone. Plasma phylloquinone, urinary -carboxyglutamic acid excretion and -carboxylation of hepatic (prothrombin) and extrahepatic proteins (osteocalcin) decreased in response to phylloquinone restriction (P < 0.001), demonstrating the production of subclinical vitamin K deficiency. The -carboxylation of prothrombin was restored to normal levels in response to phylloquinone supplementation at 200 µg/d. In contrast, all other biochemical markers of vitamin K status remained below normal levels after short-term supplementation of up to 450 µg/d of phylloquinone. These data support previous observations in rats that hepatic vitamin K-dependent proteins have preferential utilization of phylloquinone in response to phylloquinone dietary restriction. Moreover, our findings suggest that the current recommended Adequate Intake levels of vitamin K (90 µg/d) in women do not support maximal osteocalcin -carboxylation in older women
- Imprenta:
- Publisher place: Philadelphia
- Date published: 2003
- Source:
- Título: Journal of Nutrition
- ISSN: 0022-3166
- Volume/Número/Paginação/Ano: v. 133, n. 8, p. 2565-2569, 2003
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ABNT
BOOTH, Sarah L et al. Dietary phylloquinone depletion and repletion in older women. Journal of Nutrition, v. 133, n. 8, p. 2565-2569, 2003Tradução . . Acesso em: 02 dez. 2025. -
APA
Booth, S. L., Martini, L. A., Peterson, J. W., Saltzman, E., Dallal, G. E., & Wood, R. J. (2003). Dietary phylloquinone depletion and repletion in older women. Journal of Nutrition, 133( 8), 2565-2569. -
NLM
Booth SL, Martini LA, Peterson JW, Saltzman E, Dallal GE, Wood RJ. Dietary phylloquinone depletion and repletion in older women. Journal of Nutrition. 2003 ; 133( 8): 2565-2569.[citado 2025 dez. 02 ] -
Vancouver
Booth SL, Martini LA, Peterson JW, Saltzman E, Dallal GE, Wood RJ. Dietary phylloquinone depletion and repletion in older women. Journal of Nutrition. 2003 ; 133( 8): 2565-2569.[citado 2025 dez. 02 ] - Iron treatment downregulates DMT1 and IREG1 mRNA expression in caco-2 cells1
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