Dietary phylloquinone depletion and repletion in postmenopausal women: effects on bone and mineral metabolism (2006)
- Authors:
- Autor USP: MARTINI, LIGIA ARAUJO - FSP
- Unidade: FSP
- DOI: 10.1007/s00198-006-0086-1
- Subjects: VITAMINA K; DENSITOMETRIA ÓSSEA; COMPOSTOS INORGÂNICOS (METABOLISMO); MENOPAUSA (METABOLISMO); MULHERES
- Language: Inglês
- Abstract: Introduction Vitamin K has been implicated in increased bone fracture risk. Despite a potential role of vitamin K in bone, little is known about the effects of altered dietary phylloquinone intake on the underlying components of bone and mineral metabolism. Methods A 84-day in-house dietary phylloquinone (vitamin K) depletion-repletion study was undertaken in 21 postmenopausal women (mean age: 70 years) to assess the effects of altered vitamin K status on intestinal calcium (Ca) absorption, urinary and serum Ca and phosphorus (P), serum calcemic hormones, and serum biomarkers of bone turnover [osteocalcin and N-telopeptide type 1 collagen cross-links (NTx)] and the response to 1,25-dihydroxyvitamin D treatment (1 ug/day 7 d). Results The group receiving calcitriol treatment (n=11) had higher Ca absorption, urinary Ca, urinary and serum P and serum osteocalcin and lower serum parathyroid hormone (PTH).There were no significant effects of acute (4-week) phylloquinone depletion on response to 1,25-dihydroxyvitamin D treatment or on measures of bone formation or mineral metabolism. However, phylloquinone treatment had a significant effect (p< 0.01). Conclusions These findings suggest that altering vitamin K status in postmenopausal women by manipulating phylloquinone intake does not have an acute affect on intestinal Ca absorption, renal mineral excretion, or bone formation, but high phylloquinone intake may modestly reduce bone resorption. The impact of highphylloquinone intake on bone mineral density and fracture risk needs to be ascertained in randomized clinical trials
- Imprenta:
- Source:
- Título: Osteoporosis International
- ISSN: 0937-941X
- Volume/Número/Paginação/Ano: v. 17, n. 6, p. 929-935, 2006
- Este periódico é de acesso aberto
- Este artigo NÃO é de acesso aberto
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ABNT
MARTINI, Lígia Araújo et al. Dietary phylloquinone depletion and repletion in postmenopausal women: effects on bone and mineral metabolism. Osteoporosis International, v. 17, n. 6, p. 929-935, 2006Tradução . . Disponível em: https://doi.org/10.1007/s00198-006-0086-1. Acesso em: 10 fev. 2026. -
APA
Martini, L. A., Booth, S. L., Saltzman, E., Latorre, M. do R. D. de O., & Wood, R. J. (2006). Dietary phylloquinone depletion and repletion in postmenopausal women: effects on bone and mineral metabolism. Osteoporosis International, 17( 6), 929-935. doi:10.1007/s00198-006-0086-1 -
NLM
Martini LA, Booth SL, Saltzman E, Latorre M do RD de O, Wood RJ. Dietary phylloquinone depletion and repletion in postmenopausal women: effects on bone and mineral metabolism [Internet]. Osteoporosis International. 2006 ; 17( 6): 929-935.[citado 2026 fev. 10 ] Available from: https://doi.org/10.1007/s00198-006-0086-1 -
Vancouver
Martini LA, Booth SL, Saltzman E, Latorre M do RD de O, Wood RJ. Dietary phylloquinone depletion and repletion in postmenopausal women: effects on bone and mineral metabolism [Internet]. Osteoporosis International. 2006 ; 17( 6): 929-935.[citado 2026 fev. 10 ] Available from: https://doi.org/10.1007/s00198-006-0086-1 - Comparison between body mass index and a body shape index with adiponectin/leptin ratio and markers of glucose metabolism among adolescents
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Informações sobre o DOI: 10.1007/s00198-006-0086-1 (Fonte: oaDOI API)
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