Artigo de periodico

Use of amifostine in the therapy of osteosarcoma in children and adolescents (2002)

• Authors:
  • Petrilli, Antônio Sérgio
  • Oliveira, Delma Tostes
  • Ginani, Valéria Cortez
  • Kechichian, Rita
  • Dishtchekenian, Andrea
  • Roque Filho, Werthon de Medeiros
  • Tanaka, Cristiana
  • Dias, Carlos Goncalves
  • Latorre, Maria do Rosário Dias de Oliveira
  • Brunetto, Algemir Lunardi
  • Cardoso, Hedilene
  • Almeida, Maria Teresa
  • Camargo, Beatriz
• Autor USP: LATORRE, MARIA R. D. O. - FSP
• Unidade: FSP
• Assunto: OSTEOSSARCOMA (QUIMIOTERAPIA)
• Language: Inglês
• Abstract: Abstract: Amifostine protects normal tissue from the cytotoxic damage induced by radiation and chemotherapy. In this study, 39 consecutive newly diagnosed children with osteosarcoma were assessed; 20 received amifostine and 19 did not. The chemotherapy regimen included an induction phase of three cycles of cisplatin (100 mg/m2), carboplatin (500 mg/m2), and doxorubicin 160 mg/m2), followed by surgery. Alternating cycles of cisplatin/ifosfamide (9 mg/m2), ifosfamide/doxorubicin, carboplatin/doxorubicin, and ifosfamide/carboplatin were administered every 3 weeks to complete 26 weeks of treatment. Amifostine was administered 15 minutes before the infusions of cisplatin and carboplatin in a total of 193 infusions. Side effects during infusions and renal hearing, and bone marrow toxicities were evaluated and compared between the two groups. Hypotension was observed in 28 (14,5 per cent) infusions. No patient required discontinuation of therapy. Fewer than two episodes of vomiting occurred in 130 (71 per cent) infusions and two to five episodes occurred in 51 (28 per cent) infusions, and no patient had grade 4 toxicity. There was no difference between the two groups regarding renal toxicity (creatinine clearance). Neutropenia and leukopenia were significantly less frequent in the amifostine group. No difference was observed in platelet and hearing toxicities. Amifostine was well tolerated in doses of 740 mg/m2 in children and adolescents, and myelotoxicity wasless severe in the amifostine group. This was a pilot study for further evaluation in a larger randomized trial (AU)
• Imprenta:
  • Publisher place: New York
  • Date published: 2002
• Source:
  • Título: Journal of Pediatric Hematology / Oncology
  • ISSN: 1077-4114
  • Volume/Número/Paginação/Ano: v. 24, n. 3, p. 188-191, 2002

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How to cite

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• ABNT

  PETRILLI, Antônio Sérgio et al. Use of amifostine in the therapy of osteosarcoma in children and adolescents. Journal of Pediatric Hematology / Oncology, v. 24, n. 3, p. 188-191, 2002Tradução . . Acesso em: 03 out. 2024.

• APA

  Petrilli, A. S., Oliveira, D. T., Ginani, V. C., Kechichian, R., Dishtchekenian, A., Roque Filho, W. de M., et al. (2002). Use of amifostine in the therapy of osteosarcoma in children and adolescents. Journal of Pediatric Hematology / Oncology, 24( 3), 188-191.

• NLM

  Petrilli AS, Oliveira DT, Ginani VC, Kechichian R, Dishtchekenian A, Roque Filho W de M, Tanaka C, Dias CG, Latorre M do RD de O, Brunetto AL, Cardoso H, Almeida MT, Camargo B. Use of amifostine in the therapy of osteosarcoma in children and adolescents. Journal of Pediatric Hematology / Oncology. 2002 ; 24( 3): 188-191.[citado 2024 out. 03 ]

• Vancouver

  Petrilli AS, Oliveira DT, Ginani VC, Kechichian R, Dishtchekenian A, Roque Filho W de M, Tanaka C, Dias CG, Latorre M do RD de O, Brunetto AL, Cardoso H, Almeida MT, Camargo B. Use of amifostine in the therapy of osteosarcoma in children and adolescents. Journal of Pediatric Hematology / Oncology. 2002 ; 24( 3): 188-191.[citado 2024 out. 03 ]

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