Macrophages and mast cells control the neutrophil migration induced by dentin proteins (2005)
- Authors:
- USP affiliated authors: LARA, VANESSA SOARES - FOB ; SILVA, JOÃO SANTANA DA - FMRP ; CUNHA, FERNANDO DE QUEIROZ - FMRP
- Unidades: FOB; FMRP
- Subjects: QUIMIOTAXIA; PROTEÍNAS DO ESMALTE DENTÁRIO
- Language: Inglês
- Abstract: Dentin sialoprotein (DSP) and dentin phosphoprotein (DPP), the major dentin proteins, have been shown to induce neutrophil migration through release of IL-1ß, TNF-, MIP-2, and KC. However, the sources of these mediators were not determined. Here, the roles of macrophages and mast cells (MC) in dentin-induced neutrophil accumulation were investigated. Peritoneal MC depletion or the enhancement of macrophage population increased DSP- and DPP-induced neutrophil extravasation. Moreover, supernatants from DSP- and DPP-stimulated macrophages caused neutrophil migration. The release of neutrophil chemotactic factor by macrophages was inhibited by dexamethasone or the supernatant of DSP-treated MC. Consistently, dexamethasone and the MC supernatant inhibited the production of IL-1ß, TNF-, and MIP-2 by macrophages. This inhibitory activity of the DSP-stimulated MC was neutralized by anti-IL-4 and anti-IL-10 antibodies. These results indicate that dentin induces the release of the neutrophil chemotactic substance(s) by macrophages, which are down-modulated by MC-derived IL-4 and IL-10.
- Imprenta:
- Source:
- Título do periódico: Journal of Dental Research
- ISSN: 0022-0345
- Volume/Número/Paginação/Ano: v. 84, n. 1, p. 79-83, jan. 2005
-
ABNT
SILVA, T A; LARA, Vanessa Soares; SILVA, João Santana da; et al. Macrophages and mast cells control the neutrophil migration induced by dentin proteins. Journal of Dental Research, Chicago, v. 84, n. ja 2005, p. 79-83, 2005. Disponível em: < http://jdr.iadrjournals.org/cgi/reprint/84/1/79 >. -
APA
Silva, T. A., Lara, V. S., Silva, J. S. da, Oliveira, S. H. P., Butler, W. T., & Cunha, F. de Q. (2005). Macrophages and mast cells control the neutrophil migration induced by dentin proteins. Journal of Dental Research, 84( ja 2005), 79-83. Recuperado de http://jdr.iadrjournals.org/cgi/reprint/84/1/79 -
NLM
Silva TA, Lara VS, Silva JS da, Oliveira SHP, Butler WT, Cunha F de Q. Macrophages and mast cells control the neutrophil migration induced by dentin proteins [Internet]. Journal of Dental Research. 2005 ; 84( ja 2005): 79-83.Available from: http://jdr.iadrjournals.org/cgi/reprint/84/1/79 -
Vancouver
Silva TA, Lara VS, Silva JS da, Oliveira SHP, Butler WT, Cunha F de Q. Macrophages and mast cells control the neutrophil migration induced by dentin proteins [Internet]. Journal of Dental Research. 2005 ; 84( ja 2005): 79-83.Available from: http://jdr.iadrjournals.org/cgi/reprint/84/1/79 - Dentin sialoprotein and phosphoprotein induce neutrophil recruitment a mechanism dependent on IL-1(beta), TNF-(alfa), and CXC chemokines
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