Effects of hypophysectomy and acth administration on trophic response of rat adrenal gland (2004)
- Authors:
- Autor USP: LOTFI, CLAUDIMARA FERINI PACICCO - ICB
- Unidade: ICB
- Assunto: ANATOMIA
- Language: Inglês
- Abstract: The purpose of this study was to evaluate the effects of hypophysectomy on morphological changes of rat adrenal cortex gland and analyzed the fos, jun and myc protooncogenes families expression in hypophysectomized rats (HP) treated with ACTH (adrenocorticotropin) and/or FGF2 (fibroblast growth factor). A number of studies have demonstrated induction of Fos and Jun protein expression following ACTH and FGF2 treatment of adrenal cells in culture. However, the effect of ACTH and FGF2 on regulation of these protein families in the zones of adrenal cortex (glomerulosa-zG, fasciculata-zF and reticularis-zR) has not been demonstrated in vivo. Furthermore, regulation of these proteins has not been analyzed following alterations in the adrenal tropic state of an animal. Male Sprague Dawley rats were HP according to standard procedures and kept under normal diet. The operation was confirmed by physical inspection of sella turcica. HP received an i.p. injection of either saline, 10-7MACTH or/and 20ng/mlFGF2, 2h prior to harvesting the glands. Animals were killed and the gland harvested, fixed, embedded in paraffin, cut at 5µm. Morphological alterations was measured using HE stain and the protein expression was determined by immunohistochemistry. The atrophic effect of HP was in the inner adrenal cortical zones (zF and zR) and had less effect in zG and was seen within 3 days following HP. HP rats treated with ACTH showed cFos protein expression in zF
- Imprenta:
- Source:
- Título: Abstracts
- Conference titles: Congress of the Brazilian Society for Cell Biology
-
ABNT
TORRES, T. E. P. e LOTFI, Claudimara Ferini Pacicco. Effects of hypophysectomy and acth administration on trophic response of rat adrenal gland. 2004, Anais.. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2004. . Acesso em: 29 dez. 2025. -
APA
Torres, T. E. P., & Lotfi, C. F. P. (2004). Effects of hypophysectomy and acth administration on trophic response of rat adrenal gland. In Abstracts. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
Torres TEP, Lotfi CFP. Effects of hypophysectomy and acth administration on trophic response of rat adrenal gland. Abstracts. 2004 ;[citado 2025 dez. 29 ] -
Vancouver
Torres TEP, Lotfi CFP. Effects of hypophysectomy and acth administration on trophic response of rat adrenal gland. Abstracts. 2004 ;[citado 2025 dez. 29 ] - O controle da proliferação celular do córtex da suprarrenal normal e tumoral
- Stimulation of early response genes in rat adrenal primary culture cells treated with acth and FGF2
- Expressão das proteínas de genes de resposta primária em culturas de células da adrenal de rato tratadas com ACTH e FGF2
- Análise das curvas de crescimento de células de tumor funcional de supra-renal de camundongo, linhagem Y-1, sob diferentes condições de cultivo
- Differences between the growth regulatory pathways in primary rat adrenal cells and mouse tumor cell line
- The growth regulatory pathways in adrenal cells
- Analysis of signaling pathways of primary rat adrenal cells stimulated with ACTH
- Insulin-like growth factor-I receptor is a promising therapeutic target for human adrenocortical carcinoma
- Estudo da ação mitogênica do acth e do fgf2 na supra-renal de ratos
- Sinalização celular de células da supra-renal de rato estimuladas com ACTH (corticotropina) e FGF2 (fator de crescimento de fibroblastos)
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
