Retinoic acid and the evolutionary origin of cardiac chambers (2004)
- Authors:
- Autor USP: YAN, CHAO YUN IRENE - ICB
- Unidade: ICB
- Assunto: HISTOLOGIA
- Language: Inglês
- Abstract: Combining studies on cardiac anterior-posterior (AP) patterning, comparative cardiac anatomy and expression patterns of retinoic acid (RA) synthetic enzymes we suggest a new paradigm for vertebrate cardiac development and evolution. Our paradigm pictures hearts as pumps projected to perform the dual functions of inflow and outflow, functions dispensed by units, the cardiac chambers. We propose that the inflow/outflow project is expressed in the dorsal/ventral chamber organization typical of the S-shaped vertebrate heart. The inflow/outflow pattern is laid down early in development as an AP code established by differential RA signaling, dividing the cardiac field into precursors of sinus venosus plus atrium (inflow) and ventricle plus conus arteriosus (outflow). We propose that cardiac AP patterning by RA is a common vertebrate theme, but that the basic elements required for partition of the heart in this axis are already present in basal chordates. Furthermore, we speculate that the ancestral chordate had a main urochordate-like pump into vasculature similar to that of amphioxus. This pump was retained in urochordates, most likely regressed in cephalochordates and developed further in vertebrates to give rise to their typical four-chambered hearts
- Imprenta:
- Source:
- Título: Abstracts
- Conference titles: Congress of the Brazilian Society for Cell Biology
-
ABNT
SIMÕES-COSTA, Marcos S. et al. Retinoic acid and the evolutionary origin of cardiac chambers. 2004, Anais.. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2004. . Acesso em: 28 dez. 2025. -
APA
Simões-Costa, M. S., Vasconcelos, M., Sampaio, A. C., Cravo, R. M., Linhares, V. L., Hochgreb, T., et al. (2004). Retinoic acid and the evolutionary origin of cardiac chambers. In Abstracts. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
Simões-Costa MS, Vasconcelos M, Sampaio AC, Cravo RM, Linhares VL, Hochgreb T, Yan CYI, Davidson B, Xavier-Neto J. Retinoic acid and the evolutionary origin of cardiac chambers. Abstracts. 2004 ;[citado 2025 dez. 28 ] -
Vancouver
Simões-Costa MS, Vasconcelos M, Sampaio AC, Cravo RM, Linhares VL, Hochgreb T, Yan CYI, Davidson B, Xavier-Neto J. Retinoic acid and the evolutionary origin of cardiac chambers. Abstracts. 2004 ;[citado 2025 dez. 28 ] - Biologia celular de células da crista neural durante o desenvolvimento de embriões de galinha
- Slug e Snail são expressos em populações distintas de células da crista neural de Gallus gallus
- Expressão gênica exógena em embriões de galinha por eletroporação in ovo
- 40LoVe and Samba are involved in Xenopus Neural Development and Functionally Distinct from hnRNP AB
- A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field
- F6: A novel gene acting on crest migration in xenopus LAEVIS
- Slug e Snail são expressos em populações distintas de células da crista neural de Gallus gallus
- Establishment of apical domain at the lens placode during morphogenesis
- Myosin VA expression during early sensory neurogenesis
- Diferenciação celular
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
