Acute stress induced changes in interferon-gamma and physiological parameters in subjects with social phobia (2003)
- Authors:
- USP affiliated authors: GIDLUND, MAGNUS AKE - ICB ; GORENSTEIN, CLARICE - ICB
- Unidade: ICB
- Subjects: IMUNOLOGIA; FARMACOLOGIA
- Language: Português
- Abstract: Objetivo: Identify if immune changes induced by the simulated public speaking procedure would affect subjects with social phobia and without any psychiatric disorders differently. Métodos e Resultados: Subjects were assigned a public speaking task in front of a video camera. Blood samples, physiological (Systolic Blood Pressure, Galvanic Skin Response) and anxiety measures (State-Trait Anxiety Invetory STAI-S) were collected at three points in time along the procedure. NK, TCD4, TCD8 and B peripheral blood cell counts were obtained by flow cytometry and IFN-gamma, IL-2, IL-4 and IL-13 production by whole blood LPS-induced ELISA detection. The results indicate there are significative changes along time induced by the procedure, both in volunteers and patients, in SBP (p<0,000; a=0,05) and STAI-S (p<0,005; a=0,05) parameters. The changes in INF-gamma (p<0,040; a=0,05) are significatively different between both groups and along time. All the other citokines evaluated were undetectable by ELISA. Conclusões: These results show the procedure is effective to induce anxiety and identifiable immune system changes which affect differently patients and volunteers despite the briefness os the stimulus and point towards a different response profile in subjects with low anxiety threshold
- Imprenta:
- Publisher: Federação de Sociedades de Biologia Experimental
- Publisher place: Curitiba, Paraná
- Date published: 2003
- Source:
- Título do periódico: Resumos
- Conference titles: Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE
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ABNT
FAUSTINO, A. F. et al. Acute stress induced changes in interferon-gamma and physiological parameters in subjects with social phobia. 2003, Anais.. Curitiba, Paraná: Federação de Sociedades de Biologia Experimental, 2003. . Acesso em: 19 set. 2024. -
APA
Faustino, A. F., Prado, E. B. de A., Goto, H., Gidlund, M. A., Yokoo, M., Lindoso, J. A. L., et al. (2003). Acute stress induced changes in interferon-gamma and physiological parameters in subjects with social phobia. In Resumos. Curitiba, Paraná: Federação de Sociedades de Biologia Experimental. -
NLM
Faustino AF, Prado EB de A, Goto H, Gidlund MA, Yokoo M, Lindoso JAL, Lotufo-Neto F, Lotufo-Neto F, Gorenstein C. Acute stress induced changes in interferon-gamma and physiological parameters in subjects with social phobia. Resumos. 2003 ;[citado 2024 set. 19 ] -
Vancouver
Faustino AF, Prado EB de A, Goto H, Gidlund MA, Yokoo M, Lindoso JAL, Lotufo-Neto F, Lotufo-Neto F, Gorenstein C. Acute stress induced changes in interferon-gamma and physiological parameters in subjects with social phobia. Resumos. 2003 ;[citado 2024 set. 19 ] - Changes in interferon-gama and physiological parameters induced by acute stress in subjects with social phobia
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