Ativação de neutrófilos humanos por imunocomplexos (2003)
- Authors:
- Autor USP: NEGRO, SONIA JANCAR - ICB
- Unidade: ICB
- Assunto: IMUNOLOGIA
- Language: Português
- Abstract: Objective: The effect of antagonists of bradykinin B2 receptor, HOE-140 (constitutive) and of B1receptor, R-954 (inducible) was studied in allergic and immune-complex-induced lung inflammation. Methods and results: Lungs of BALB/c mice were examined 24h after induction of lung inflammation either allergic (ovalbumin-sensitized submitted to two aerosol of antigen, one week apart) or immune-complex induced (intratracheal instillation of IgG antibodies to BSA followed by intravenous antigen). Compounds HOE-140 or R-954 were given intraperitoneally (100 mug/kg), 30 min before induction. In allergic inflammation, pre-treatment with R-954 reduced eosinophil infiltration (92%), mucus secretion (75%) and the airway hyperreactivity (84%) to methacholine. Pre-treatment with HOE-140 increased eosinophil infiltration (207%) but did not affect the other parameters. In immune-complex inflammation, HOE-140 increased neutrophil infiltration (58%) but not their activation nor the hemorrhagic lesions. Pre-treatment with R-594 did not change the parameters examined.Conclusion: These results suggest that activation of the constitutive bradykinin receptor down-regulates both types of lung inflammation whereas the inducible receptor participates only in the allergic inflammation where it has pro-inflammatory effects
- Imprenta:
- Publisher: Comissão de Pesquisa do ICB/USP
- Publisher place: São Paulo
- Date published: 2003
- Source:
- Título do periódico: Resumos
- Conference titles: Congresso Instituto Ciências Biomédicas, IV
-
ABNT
PAULINO, Ellena Christina; NEGRO, Sonia Jancar; STEIL, A. A. Ativação de neutrófilos humanos por imunocomplexos. Anais.. São Paulo: Comissão de Pesquisa do ICB/USP, 2003. -
APA
Paulino, E. C., Negro, S. J., & Steil, A. A. (2003). Ativação de neutrófilos humanos por imunocomplexos. In Resumos. São Paulo: Comissão de Pesquisa do ICB/USP. -
NLM
Paulino EC, Negro SJ, Steil AA. Ativação de neutrófilos humanos por imunocomplexos. Resumos. 2003 ; -
Vancouver
Paulino EC, Negro SJ, Steil AA. Ativação de neutrófilos humanos por imunocomplexos. Resumos. 2003 ; - Participação das endotelinas em fenômenos de interação entre leucócitos e endotélio: estudos in vitro
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