The development of experimental autoimmune encephalomyelitis could be completed abrogated by immunossuppressive effect of Trypanosoma cruzi infection (2001)
- Authors:
- USP affiliated authors: RIZZO, LUIZ VICENTE - ICB ; ABRAHAMSOHN, ISES DE ALMEIDA - ICB
- Unidade: ICB
- Assunto: IMUNOLOGIA
- Language: Inglês
- Abstract: Objective: to study how intracellular parasite infections can modulate the development of autoimmune diseases. Methods: IL-10 or iNOS knock out (KO) mice in the C57Bl/6 background and their matching wild type (WT) controls were immunized with 100 mg of MOG 35-55 peptide emulsified vol/vol in CFA enriched with 400 mg of M. bovis. Each mouse received 100 ng of Pertussis toxin intravenously at the same day of immunization and 2 days after, as an additional adjuvant. Groups of mice were also infected with 1000 blood forms of T. cruzi Y strain concomitantly to immunization. After the immunization/infection, the clinical score of EAE was followed and lymph node cells or spleen cells (SC) cultures were performed on days 7th, 14th or 21st to evaluate the proliferative and cytokine responses against the MOG peptide. Results: The infection with T. cruzi completely prevented EAE development and resulted in suppressed of proliferative responses of LNC and SC to MOG 35-55. The blockade of EAE was partially reverted in iNOS or IL-10 KO mice. Interestingly, SC cultures from WT mice immunized and infected produced large amounts of IL-10 after MOG 35-55 stimulation. Conclusion: the results suggest that NO and IL-10 produced during T. cruzi infection may suppress the development of EAE
- Imprenta:
- Publisher: Comissão de Cultura e Extensão Universitária do ICB/USP
- Publisher place: São Paulo
- Date published: 2001
- Source:
- Título do periódico: Resumos
- Conference titles: Congresso do Instituto de Ciências Biomédicas
-
ABNT
TADOKORO, C E et al. The development of experimental autoimmune encephalomyelitis could be completed abrogated by immunossuppressive effect of Trypanosoma cruzi infection. 2001, Anais.. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP, 2001. . Acesso em: 20 set. 2024. -
APA
Tadokoro, C. E., Vallochi,, Rios, L., Schesinger, D., Mosca, T., Kuchroo, V. K., et al. (2001). The development of experimental autoimmune encephalomyelitis could be completed abrogated by immunossuppressive effect of Trypanosoma cruzi infection. In Resumos. São Paulo: Comissão de Cultura e Extensão Universitária do ICB/USP. -
NLM
Tadokoro CE, Vallochi, Rios L, Schesinger D, Mosca T, Kuchroo VK, Rizzo LV, Abrahamsohn I de A. The development of experimental autoimmune encephalomyelitis could be completed abrogated by immunossuppressive effect of Trypanosoma cruzi infection. Resumos. 2001 ;[citado 2024 set. 20 ] -
Vancouver
Tadokoro CE, Vallochi, Rios L, Schesinger D, Mosca T, Kuchroo VK, Rizzo LV, Abrahamsohn I de A. The development of experimental autoimmune encephalomyelitis could be completed abrogated by immunossuppressive effect of Trypanosoma cruzi infection. Resumos. 2001 ;[citado 2024 set. 20 ] - Trypanosoma cruzi infection inhibits autoimmune encephalomyelitis
- The effect of t. cruzi infection over eae development
- Lack of experimental autoimmune encephalomyelitis (EAE) in mice infected with Trypanosoma cruzi
- Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosoma cruzi
- Lack of experimental autoimmune encephalomyelitis (EAE) in mice infected with Trypanosoma cruzi
- High molecular weight components from Ascaris suum exert suppressive effect on dendritic cells
- Endogenously produced IL-10 and prostaglandins regulate peripheral blood mononuclear cells proliferation to Trypanosoma cruzi antigens
- Nitric oxide produced by macrophages and regulation of resistance to "Trypanosoma cruzi" at the initial phase of infection
- Egulation of Trypanosoma cruzi infection by type interferons
- Il-12 regulation of ifn-gama synthesis in the acute phase of trypanosoma cruzi infection
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