TY - JOUR TI - Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases PY - 2017 AU - Castro-Fernandez, Víctor AU - Herrera-Morande, Alejandra AU - Zamora, Ricardo AU - Merino, Felipe AU - Gonzalez-Ordenes, Felipe AU - Padilla-Salinas, Felipe AU - Pereira, Humberto d'Muniz AU - Brandão-Neto, José AU - Garratt, Richard Charles AU - Guixe, Victoria T2 - Journal of Biological Chemistry SN - 1083-351X DO - 10.1074/jbc.M117.790865 UR - https://doi.org/10.1074/jbc.M117.790865 PP - Rockville VL - 292 IS - 38 SP - 15598-15993 + Supplemental data ER -