Mutant thyroglobulin is retained in the endoplasmatic reticulum (ER) due to abnormal folding as a consequence of a novel mutation (A2215D) in the ache region of the TG gene - Pardo, V.; Vono, Toniolo J.; Rubio, I. G. S.; Knobel, M.; Kopp, P.; Medeiros-Neto, G. (Congress Thyroid Society, 2007)