A gene wich causes severe ocular alterations and occipital encephalocele (Knobloch syndrome) is mapped to 21q22.3 - Sertié, A L; Quimby, M; Moreira, E S; Murray, J; Zatz, Mayana; Antonarakis, S E; Passos-Bueno, Maria Rita (Human Molecular Genetics, 1996)