Characterization of the transforming growth factor-'beta' (TGF-'beta') antagonist expression in the cells of the ciliary marginal zone (CMZ) (2004)
- Autores:
- Autor USP: YAN, CHAO YUN IRENE - ICB
- Unidade: ICB
- Assunto: HISTOLOGIA
- Idioma: Inglês
- Resumo: The Ciliary Marginal Zone (CMZ) is located at the meeting between the Retinal Pigmented Epithelium and the neural retina and contains neural stem cells that are capable of proliferating and differentiating into different retinal cell types. Since stem cell differentiation and proliferation are often controlled by the same pathways relevant for embryogenesis, we propose to investigate the role of TGF-'beta' in the CMZ. During embryogenesis, regulation of the TGF-'beta' pathway plays a decisive role in determining the formation of nervous or epithelial tissue from neuroectoderm. Activation of TGF-'beta' pathways induces epithelial tissue, whilst inhibition by antagonists such as noggin and follistatin allow the formation of neural tissue. Thus, we hypothesized that the balance of TGF-'beta' ligands and antagonists in the CMZ is also relevant in determining the fate of the stem cells located there. To verify this, we processed eyes from 5 days old chick for in situ hybridizations for noggin and follistatin mRNA. We observed that the expression pattern of these TGF-'beta' antagonists differ significantly. In the central retina, noggin and follistatin were found in the ganglionar nuclear layer (GCL). While Noggin levels at the GCL were constant throughout the retina, follistatin levels decreased significantly at the periphery. Both TGF-'beta' antagonists were present in the peripheral INL but not in central INL. Overall distribution of noggin and follistatin was broader at theperipheral than central retina
- Imprenta:
- Fonte:
- Título do periódico: Abstracts
- Nome do evento: Congress of the Brazilian Society for Cell Biology
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ABNT
LIMA, I. P. e YAN, Chao Yun Irene. Characterization of the transforming growth factor-'beta' (TGF-'beta') antagonist expression in the cells of the ciliary marginal zone (CMZ). 2004, Anais.. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo, 2004. . Acesso em: 29 mar. 2024. -
APA
Lima, I. P., & Yan, C. Y. I. (2004). Characterization of the transforming growth factor-'beta' (TGF-'beta') antagonist expression in the cells of the ciliary marginal zone (CMZ). In Abstracts. Campinas: Instituto de Ciências Biomédicas, Universidade de São Paulo. -
NLM
Lima IP, Yan CYI. Characterization of the transforming growth factor-'beta' (TGF-'beta') antagonist expression in the cells of the ciliary marginal zone (CMZ). Abstracts. 2004 ;[citado 2024 mar. 29 ] -
Vancouver
Lima IP, Yan CYI. Characterization of the transforming growth factor-'beta' (TGF-'beta') antagonist expression in the cells of the ciliary marginal zone (CMZ). Abstracts. 2004 ;[citado 2024 mar. 29 ] - Biologia celular de células da crista neural durante o desenvolvimento de embriões de galinha
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