Filtros : "Davies, Neal M" Removido: "XENOBIÓTICO" Limpar

Filtros



Refine with date range


  • Source: Pharmaceutics. Unidade: FCF

    Subjects: FARMACOCINÉTICA, FARMACODINÂMICA

    Versão PublicadaAcesso à fonteDOIHow to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
    • ABNT

      YOUSEF, Malaz et al. In vitro predictive model for intestinal lymphatic uptake: exploration of additional enhancers and inhibitors. Pharmaceutics, v. 16, n. 6 p. 1-13 art. 768, 2024Tradução . . Disponível em: https://dx.doi.org/10.3390/pharmaceutics16060768. Acesso em: 10 nov. 2024.
    • APA

      Yousef, M., O’Croinin, C., Le, T. S., Park, C., Zuo, J., Bou-Chacra, N. A., et al. (2024). In vitro predictive model for intestinal lymphatic uptake: exploration of additional enhancers and inhibitors. Pharmaceutics, 16( 6 p. 1-13 art. 768). doi:10.3390/pharmaceutics16060768
    • NLM

      Yousef M, O’Croinin C, Le TS, Park C, Zuo J, Bou-Chacra NA, Davies NM, Löbenberg R. In vitro predictive model for intestinal lymphatic uptake: exploration of additional enhancers and inhibitors [Internet]. Pharmaceutics. 2024 ; 16( 6 p. 1-13 art. 768):[citado 2024 nov. 10 ] Available from: https://dx.doi.org/10.3390/pharmaceutics16060768
    • Vancouver

      Yousef M, O’Croinin C, Le TS, Park C, Zuo J, Bou-Chacra NA, Davies NM, Löbenberg R. In vitro predictive model for intestinal lymphatic uptake: exploration of additional enhancers and inhibitors [Internet]. Pharmaceutics. 2024 ; 16( 6 p. 1-13 art. 768):[citado 2024 nov. 10 ] Available from: https://dx.doi.org/10.3390/pharmaceutics16060768
  • Source: Journal of Drug Delivery Science and Technology. Unidade: FCF

    Subjects: DEPRESSÃO, MEDICAMENTO

    Acesso à fonteDOIHow to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
    • ABNT

      RICHTER, Luca Maurice et al. Assessing the utility of in silico tools in early drug development: The case of a pharmaceutically relevant formulation of the prodrug psilocybin. Journal of Drug Delivery Science and Technology, v. 92, p. 1-14, 2024Tradução . . Disponível em: https://dx.doi.org/10.1016/j.jddst.2023.105305. Acesso em: 10 nov. 2024.
    • APA

      Richter, L. M., Al-Gousous, J., Araujo, G. L. B. de, Davies, N. M., & Löbenberg, R. (2024). Assessing the utility of in silico tools in early drug development: The case of a pharmaceutically relevant formulation of the prodrug psilocybin. Journal of Drug Delivery Science and Technology, 92, 1-14. doi:10.1016/j.jddst.2023.105305
    • NLM

      Richter LM, Al-Gousous J, Araujo GLB de, Davies NM, Löbenberg R. Assessing the utility of in silico tools in early drug development: The case of a pharmaceutically relevant formulation of the prodrug psilocybin [Internet]. Journal of Drug Delivery Science and Technology. 2024 ; 92 1-14.[citado 2024 nov. 10 ] Available from: https://dx.doi.org/10.1016/j.jddst.2023.105305
    • Vancouver

      Richter LM, Al-Gousous J, Araujo GLB de, Davies NM, Löbenberg R. Assessing the utility of in silico tools in early drug development: The case of a pharmaceutically relevant formulation of the prodrug psilocybin [Internet]. Journal of Drug Delivery Science and Technology. 2024 ; 92 1-14.[citado 2024 nov. 10 ] Available from: https://dx.doi.org/10.1016/j.jddst.2023.105305
  • Source: AAPS PharmSciTech. Unidade: FCF

    Subjects: MEDICAÇÃO ORAL, VASOS LINFÁTICOS

    Acesso à fonteDOIHow to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
    • ABNT

      YOUSEF, Malaz et al. Novel first-generation dissolution models to investigate the release and uptake of oral Lymphotropic drug products. AAPS PharmSciTech, v. 25, p. 1-9 art. 187, 2024Tradução . . Disponível em: https://dx.doi.org/10.1208/s12249-024-02866-y. Acesso em: 10 nov. 2024.
    • APA

      Yousef, M., Park, C., Bou-Chacra, N. A., Davies, N. M., & Löbenberg, R. (2024). Novel first-generation dissolution models to investigate the release and uptake of oral Lymphotropic drug products. AAPS PharmSciTech, 25, 1-9 art. 187. doi:10.1208/s12249-024-02866-y
    • NLM

      Yousef M, Park C, Bou-Chacra NA, Davies NM, Löbenberg R. Novel first-generation dissolution models to investigate the release and uptake of oral Lymphotropic drug products [Internet]. AAPS PharmSciTech. 2024 ; 25 1-9 art. 187.[citado 2024 nov. 10 ] Available from: https://dx.doi.org/10.1208/s12249-024-02866-y
    • Vancouver

      Yousef M, Park C, Bou-Chacra NA, Davies NM, Löbenberg R. Novel first-generation dissolution models to investigate the release and uptake of oral Lymphotropic drug products [Internet]. AAPS PharmSciTech. 2024 ; 25 1-9 art. 187.[citado 2024 nov. 10 ] Available from: https://dx.doi.org/10.1208/s12249-024-02866-y
  • Source: Research in Pharmaceutical Sciences. Unidade: FCF

    Subjects: LISOSSOMOS, MEDICAMENTO

    Acesso à fonteDOIHow to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
    • ABNT

      YOUSEF, Malaz et al. Sub-cellular sequestration of alkaline drugs in lysosomes: new insights for pharmaceutical development of lysosomal fluid. Research in Pharmaceutical Sciences, v. 18, n. 1, p. 1-15, 2023Tradução . . Disponível em: https://doi.org/10.4103/1735-5362.363591. Acesso em: 10 nov. 2024.
    • APA

      Yousef, M., Le, T. S., Zuo, J., Park, C., Bou-Chacra, N. A., Davies, N. M., & Löbenberg, R. (2023). Sub-cellular sequestration of alkaline drugs in lysosomes: new insights for pharmaceutical development of lysosomal fluid. Research in Pharmaceutical Sciences, 18( 1), 1-15. doi:10.4103/1735-5362.363591
    • NLM

      Yousef M, Le TS, Zuo J, Park C, Bou-Chacra NA, Davies NM, Löbenberg R. Sub-cellular sequestration of alkaline drugs in lysosomes: new insights for pharmaceutical development of lysosomal fluid [Internet]. Research in Pharmaceutical Sciences. 2023 ; 18( 1): 1-15.[citado 2024 nov. 10 ] Available from: https://doi.org/10.4103/1735-5362.363591
    • Vancouver

      Yousef M, Le TS, Zuo J, Park C, Bou-Chacra NA, Davies NM, Löbenberg R. Sub-cellular sequestration of alkaline drugs in lysosomes: new insights for pharmaceutical development of lysosomal fluid [Internet]. Research in Pharmaceutical Sciences. 2023 ; 18( 1): 1-15.[citado 2024 nov. 10 ] Available from: https://doi.org/10.4103/1735-5362.363591
  • Source: Pharmaceutics. Unidade: FCF

    Subjects: SISTEMA LINFÁTICO, MEDICAMENTO

    Versão PublicadaAcesso à fonteDOIHow to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
    • ABNT

      YOUSEF, Malaz et al. Development of a novel in vitro model to study lymphatic uptake of drugs via artificial chylomicrons. Pharmaceutics, v. 2, p. 1-17 art. 2532, 2023Tradução . . Disponível em: https://dx.doi.org/10.3390/pharmaceutics15112532. Acesso em: 10 nov. 2024.
    • APA

      Yousef, M., Park, C., Henostroza, M., Bou-Chacra, N. A., Davies, N. M., & Löbenberg, R. (2023). Development of a novel in vitro model to study lymphatic uptake of drugs via artificial chylomicrons. Pharmaceutics, 2, 1-17 art. 2532. doi:10.3390/pharmaceutics15112532
    • NLM

      Yousef M, Park C, Henostroza M, Bou-Chacra NA, Davies NM, Löbenberg R. Development of a novel in vitro model to study lymphatic uptake of drugs via artificial chylomicrons [Internet]. Pharmaceutics. 2023 ; 2 1-17 art. 2532.[citado 2024 nov. 10 ] Available from: https://dx.doi.org/10.3390/pharmaceutics15112532
    • Vancouver

      Yousef M, Park C, Henostroza M, Bou-Chacra NA, Davies NM, Löbenberg R. Development of a novel in vitro model to study lymphatic uptake of drugs via artificial chylomicrons [Internet]. Pharmaceutics. 2023 ; 2 1-17 art. 2532.[citado 2024 nov. 10 ] Available from: https://dx.doi.org/10.3390/pharmaceutics15112532
  • Source: Applied Chemical Engineering. Unidade: FCF

    Subjects: LIPOPROTEÍNAS, SISTEMA LINFÁTICO

    Acesso à fonteDOIHow to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
    • ABNT

      YOUSEF, Malaz et al. Lipoproteins within the lymphatic system: Insights into health, disease, and therapeutic implications. Applied Chemical Engineering, v. 6, n. 2, p. 1-7, 2023Tradução . . Disponível em: https://doi.org/10.24294/ace.v6i2.2202. Acesso em: 10 nov. 2024.
    • APA

      Yousef, M., Bou-Chacra, N. A., Davies, N. M., & Löbenberg, R. (2023). Lipoproteins within the lymphatic system: Insights into health, disease, and therapeutic implications. Applied Chemical Engineering, 6( 2), 1-7. doi:10.24294/ace.v6i2.2202
    • NLM

      Yousef M, Bou-Chacra NA, Davies NM, Löbenberg R. Lipoproteins within the lymphatic system: Insights into health, disease, and therapeutic implications [Internet]. Applied Chemical Engineering. 2023 ; 6( 2): 1-7.[citado 2024 nov. 10 ] Available from: https://doi.org/10.24294/ace.v6i2.2202
    • Vancouver

      Yousef M, Bou-Chacra NA, Davies NM, Löbenberg R. Lipoproteins within the lymphatic system: Insights into health, disease, and therapeutic implications [Internet]. Applied Chemical Engineering. 2023 ; 6( 2): 1-7.[citado 2024 nov. 10 ] Available from: https://doi.org/10.24294/ace.v6i2.2202
  • Source: Dissolutiom Technologies. Unidade: FCF

    Subjects: FÁRMACOS, SISTEMA LINFÁTICO

    Acesso à fonteDOIHow to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
    • ABNT

      YOUSEF, Malaz et al. Simulated lymphatic fluid for in-vitro assessment in pharmaceutical development. Dissolutiom Technologies, v. 29, n. 2, p. 86-93, 2022Tradução . . Disponível em: https://doi.org/10.14227/DT290222P86. Acesso em: 10 nov. 2024.
    • APA

      Yousef, M., Park, C., Le, T. S., Bou-Chacra, N. A., Davies, N. M., & Löbenberg, R. (2022). Simulated lymphatic fluid for in-vitro assessment in pharmaceutical development. Dissolutiom Technologies, 29( 2), 86-93. doi:10.14227/DT290222P86
    • NLM

      Yousef M, Park C, Le TS, Bou-Chacra NA, Davies NM, Löbenberg R. Simulated lymphatic fluid for in-vitro assessment in pharmaceutical development [Internet]. Dissolutiom Technologies. 2022 ; 29( 2): 86-93.[citado 2024 nov. 10 ] Available from: https://doi.org/10.14227/DT290222P86
    • Vancouver

      Yousef M, Park C, Le TS, Bou-Chacra NA, Davies NM, Löbenberg R. Simulated lymphatic fluid for in-vitro assessment in pharmaceutical development [Internet]. Dissolutiom Technologies. 2022 ; 29( 2): 86-93.[citado 2024 nov. 10 ] Available from: https://doi.org/10.14227/DT290222P86
  • Source: Dissolution Technologies. Unidade: FCF

    Subjects: TRATO GASTROINTESTINAL, FARMACOCINÉTICA, MEDICAMENTO

    Acesso à fonteDOIHow to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
    • ABNT

      SILVA, Daniela Amaral et al. Update on gastrointestinal biorelevant media and physiologically relevant dissolution conditions. Dissolution Technologies, v. 29, n. 2, p. 62-75, 2022Tradução . . Disponível em: https://doi.org/10.14227/DT290222P62. Acesso em: 10 nov. 2024.
    • APA

      Silva, D. A., Davies, N. M., Bou-Chacra, N. A., Ferraz, H. G., & Löbenberg, R. (2022). Update on gastrointestinal biorelevant media and physiologically relevant dissolution conditions. Dissolution Technologies, 29( 2), 62-75. doi:10.14227/DT290222P62
    • NLM

      Silva DA, Davies NM, Bou-Chacra NA, Ferraz HG, Löbenberg R. Update on gastrointestinal biorelevant media and physiologically relevant dissolution conditions [Internet]. Dissolution Technologies. 2022 ; 29( 2): 62-75.[citado 2024 nov. 10 ] Available from: https://doi.org/10.14227/DT290222P62
    • Vancouver

      Silva DA, Davies NM, Bou-Chacra NA, Ferraz HG, Löbenberg R. Update on gastrointestinal biorelevant media and physiologically relevant dissolution conditions [Internet]. Dissolution Technologies. 2022 ; 29( 2): 62-75.[citado 2024 nov. 10 ] Available from: https://doi.org/10.14227/DT290222P62
  • Source: Dissolution Technology. Unidade: FCF

    Subjects: BIOEQUIVALÊNCIA, FARMACOCINÉTICA

    Acesso à fonteDOIHow to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
    • ABNT

      SILVA, Daniela Amaral et al. A BCS-based biowaiver approach using biphasic dissolution test. Dissolution Technology, v. 28, n. 4, p. 40-48, 2021Tradução . . Disponível em: https://doi.org/10.14227/DT280421P40. Acesso em: 10 nov. 2024.
    • APA

      Silva, D. A., Melo, K. J. C., Davies, N. M., Bou-Chacra, N. A., Ferraz, H. G., & Löbenberg, R. (2021). A BCS-based biowaiver approach using biphasic dissolution test. Dissolution Technology, 28( 4), 40-48. doi:10.14227/DT280421P40
    • NLM

      Silva DA, Melo KJC, Davies NM, Bou-Chacra NA, Ferraz HG, Löbenberg R. A BCS-based biowaiver approach using biphasic dissolution test [Internet]. Dissolution Technology. 2021 ; 28( 4): 40-48.[citado 2024 nov. 10 ] Available from: https://doi.org/10.14227/DT280421P40
    • Vancouver

      Silva DA, Melo KJC, Davies NM, Bou-Chacra NA, Ferraz HG, Löbenberg R. A BCS-based biowaiver approach using biphasic dissolution test [Internet]. Dissolution Technology. 2021 ; 28( 4): 40-48.[citado 2024 nov. 10 ] Available from: https://doi.org/10.14227/DT280421P40
  • Source: Journal of Pharmacy & Pharmaceutical Sciences. Unidade: FCF

    Subjects: SISTEMA LINFÁTICO, FISIOLOGIA

    Versão PublicadaAcesso à fonteDOIHow to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
    • ABNT

      YOUSEF, Malaz et al. The lymphatic system: a sometimes-forgotten compartment in pharmaceutical sciences. Journal of Pharmacy & Pharmaceutical Sciences, v. 24, p. 533-547, 2021Tradução . . Disponível em: https://doi.org/10.18433/jpps32222. Acesso em: 10 nov. 2024.
    • APA

      Yousef, M., Silva, D. A., Bou-Chacra, N. A., Davies, N. M., & Löbenberg, R. (2021). The lymphatic system: a sometimes-forgotten compartment in pharmaceutical sciences. Journal of Pharmacy & Pharmaceutical Sciences, 24, 533-547. doi:10.18433/jpps32222
    • NLM

      Yousef M, Silva DA, Bou-Chacra NA, Davies NM, Löbenberg R. The lymphatic system: a sometimes-forgotten compartment in pharmaceutical sciences [Internet]. Journal of Pharmacy & Pharmaceutical Sciences. 2021 ; 24 533-547.[citado 2024 nov. 10 ] Available from: https://doi.org/10.18433/jpps32222
    • Vancouver

      Yousef M, Silva DA, Bou-Chacra NA, Davies NM, Löbenberg R. The lymphatic system: a sometimes-forgotten compartment in pharmaceutical sciences [Internet]. Journal of Pharmacy & Pharmaceutical Sciences. 2021 ; 24 533-547.[citado 2024 nov. 10 ] Available from: https://doi.org/10.18433/jpps32222
  • Source: Pharmaceutics. Unidade: FCF

    Subjects: ANTI-INFLAMATÓRIOS, FÁRMACOS

    Versão PublicadaAcesso à fonteDOIHow to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
    • ABNT

      SILVA, Daniela Amaral et al. Biphasic dissolution as an exploratory method during early drug product development. Pharmaceutics, v. 12, p. 1-17 art, 2020Tradução . . Disponível em: https://doi.org/10.3390/pharmaceutics12050420. Acesso em: 10 nov. 2024.
    • APA

      Silva, D. A., Gousous, J. A., Davies, N. M., Bou-Chacra, N. A., Webster, G. K., Lipka, E., et al. (2020). Biphasic dissolution as an exploratory method during early drug product development. Pharmaceutics, 12, 1-17 art. doi:10.3390/pharmaceutics12050420
    • NLM

      Silva DA, Gousous JA, Davies NM, Bou-Chacra NA, Webster GK, Lipka E, Amidon GL, Löbenberg R. Biphasic dissolution as an exploratory method during early drug product development [Internet]. Pharmaceutics. 2020 ; 12 1-17 art.[citado 2024 nov. 10 ] Available from: https://doi.org/10.3390/pharmaceutics12050420
    • Vancouver

      Silva DA, Gousous JA, Davies NM, Bou-Chacra NA, Webster GK, Lipka E, Amidon GL, Löbenberg R. Biphasic dissolution as an exploratory method during early drug product development [Internet]. Pharmaceutics. 2020 ; 12 1-17 art.[citado 2024 nov. 10 ] Available from: https://doi.org/10.3390/pharmaceutics12050420
  • Source: Journal of Controlled Release. Unidade: FCF

    Assunto: FÁRMACOS

    Acesso à fonteDOIHow to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
    • ABNT

      SILVA, Daniela Amaral et al. Mechanistic understanding of underperforming enteric coated products: opportunities to add clinical relevance to the dissolution test. Journal of Controlled Release, v. 325, p. 23-334, 2020Tradução . . Disponível em: https://doi.org/10.1016/j.jconrel.2020.06.031. Acesso em: 10 nov. 2024.
    • APA

      Silva, D. A., Davies, N. M., Doschak, M. R., Al-Gousous, J., Bou-Chacra, N. A., & Löbenberg, R. (2020). Mechanistic understanding of underperforming enteric coated products: opportunities to add clinical relevance to the dissolution test. Journal of Controlled Release, 325, 23-334. doi:10.1016/j.jconrel.2020.06.031
    • NLM

      Silva DA, Davies NM, Doschak MR, Al-Gousous J, Bou-Chacra NA, Löbenberg R. Mechanistic understanding of underperforming enteric coated products: opportunities to add clinical relevance to the dissolution test [Internet]. Journal of Controlled Release. 2020 ; 325 23-334.[citado 2024 nov. 10 ] Available from: https://doi.org/10.1016/j.jconrel.2020.06.031
    • Vancouver

      Silva DA, Davies NM, Doschak MR, Al-Gousous J, Bou-Chacra NA, Löbenberg R. Mechanistic understanding of underperforming enteric coated products: opportunities to add clinical relevance to the dissolution test [Internet]. Journal of Controlled Release. 2020 ; 325 23-334.[citado 2024 nov. 10 ] Available from: https://doi.org/10.1016/j.jconrel.2020.06.031
  • Source: European Journal of Pharmaceutics and Biopharmaceutics. Unidade: FCF

    Subjects: FÁRMACOS, FORMAS FARMACÊUTICAS

    Acesso à fonteDOIHow to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
    • ABNT

      SILVA, Daniela Amaral et al. Simulated, biorelevant, clinically relevant or physiologically relevant dissolution media: the hidden role of bicarbonate buffer. European Journal of Pharmaceutics and Biopharmaceutics, v. 142, p. 8-19, 2019Tradução . . Disponível em: https://doi.org/10.1016/j.ejpb.2019.06.006. Acesso em: 10 nov. 2024.
    • APA

      Silva, D. A., Gousous, J. A., Davies, N. M., Bou-Chacra, N. A., Webster, G. K., Lipka, E., et al. (2019). Simulated, biorelevant, clinically relevant or physiologically relevant dissolution media: the hidden role of bicarbonate buffer. European Journal of Pharmaceutics and Biopharmaceutics, 142, 8-19. doi:10.1016/j.ejpb.2019.06.006
    • NLM

      Silva DA, Gousous JA, Davies NM, Bou-Chacra NA, Webster GK, Lipka E, Amidon G, Löbenberg R. Simulated, biorelevant, clinically relevant or physiologically relevant dissolution media: the hidden role of bicarbonate buffer [Internet]. European Journal of Pharmaceutics and Biopharmaceutics. 2019 ; 142 8-19.[citado 2024 nov. 10 ] Available from: https://doi.org/10.1016/j.ejpb.2019.06.006
    • Vancouver

      Silva DA, Gousous JA, Davies NM, Bou-Chacra NA, Webster GK, Lipka E, Amidon G, Löbenberg R. Simulated, biorelevant, clinically relevant or physiologically relevant dissolution media: the hidden role of bicarbonate buffer [Internet]. European Journal of Pharmaceutics and Biopharmaceutics. 2019 ; 142 8-19.[citado 2024 nov. 10 ] Available from: https://doi.org/10.1016/j.ejpb.2019.06.006
  • Source: Journal of Pharmacy and Pharmaceutical Sciences. Unidade: FCF

    Subjects: ANTIFÚNGICOS, FÁRMACOS

    Acesso à fonteHow to cite
    A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
    • ABNT

      SILVA, Daniela Amaral et al. Application of in silico tools in clinical practice using Ketoconazole as a model drug. Journal of Pharmacy and Pharmaceutical Sciences, v. 21, n. 1s, p. 242s-253s, 2018Tradução . . Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/30348250. Acesso em: 10 nov. 2024.
    • APA

      Silva, D. A., Duque, M. D., Davies, N. M., Löbenberg, R., & Ferraz, H. G. (2018). Application of in silico tools in clinical practice using Ketoconazole as a model drug. Journal of Pharmacy and Pharmaceutical Sciences, 21( 1s), 242s-253s. Recuperado de https://www.ncbi.nlm.nih.gov/pubmed/30348250
    • NLM

      Silva DA, Duque MD, Davies NM, Löbenberg R, Ferraz HG. Application of in silico tools in clinical practice using Ketoconazole as a model drug [Internet]. Journal of Pharmacy and Pharmaceutical Sciences. 2018 ; 21( 1s): 242s-253s.[citado 2024 nov. 10 ] Available from: https://www.ncbi.nlm.nih.gov/pubmed/30348250
    • Vancouver

      Silva DA, Duque MD, Davies NM, Löbenberg R, Ferraz HG. Application of in silico tools in clinical practice using Ketoconazole as a model drug [Internet]. Journal of Pharmacy and Pharmaceutical Sciences. 2018 ; 21( 1s): 242s-253s.[citado 2024 nov. 10 ] Available from: https://www.ncbi.nlm.nih.gov/pubmed/30348250

Digital Library of Intellectual Production of Universidade de São Paulo     2012 - 2024