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SALIBA, Ana Sofia Martelli Chaib et al. Brazilian propolis microencapsulation: effects on biological activities and gut modulation. 2024, Anais.. Porto: INFOGEST, 2024. Disponível em: https://www.icfd2024.com/c%C3%B3pia-news. Acesso em: 16 nov. 2024.
APA
Saliba, A. S. M. C., Belo, T. C. A., Santos, N., Bruzadelli, R. F. D., Sá, S. G. de, Favaro-Trindade, C. S., et al. (2024). Brazilian propolis microencapsulation: effects on biological activities and gut modulation. In Book of Abstracts. Porto: INFOGEST. Recuperado de https://www.icfd2024.com/c%C3%B3pia-news
NLM
Saliba ASMC, Belo TCA, Santos N, Bruzadelli RFD, Sá SG de, Favaro-Trindade CS, Ikegaki M, Sartori AG de O, Almeida L, Alencar SM de. Brazilian propolis microencapsulation: effects on biological activities and gut modulation [Internet]. Book of Abstracts. 2024 ;[citado 2024 nov. 16 ] Available from: https://www.icfd2024.com/c%C3%B3pia-news
Vancouver
Saliba ASMC, Belo TCA, Santos N, Bruzadelli RFD, Sá SG de, Favaro-Trindade CS, Ikegaki M, Sartori AG de O, Almeida L, Alencar SM de. Brazilian propolis microencapsulation: effects on biological activities and gut modulation [Internet]. Book of Abstracts. 2024 ;[citado 2024 nov. 16 ] Available from: https://www.icfd2024.com/c%C3%B3pia-news
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CAMPOS, Thaíssa Giovanna Valverde et al. New records on toxic cyanobacteria from Brazil: exploring their occurrence and geography. Science of The Total Environment, v. 931, p. 1-14 art. 172689, 2024Tradução . . Disponível em: https://dx.doi.org/10.1016/j.scitotenv.2024.172689. Acesso em: 16 nov. 2024.
APA
Campos, T. G. V., Gama, W. A., Geraldes, V., Yoon, J., Crnkovic, C. M., Pinto, E., & Jacinavicius, F. R. (2024). New records on toxic cyanobacteria from Brazil: exploring their occurrence and geography. Science of The Total Environment, 931, 1-14 art. 172689. doi:10.1016/j.scitotenv.2024.172689
NLM
Campos TGV, Gama WA, Geraldes V, Yoon J, Crnkovic CM, Pinto E, Jacinavicius FR. New records on toxic cyanobacteria from Brazil: exploring their occurrence and geography [Internet]. Science of The Total Environment. 2024 ; 931 1-14 art. 172689.[citado 2024 nov. 16 ] Available from: https://dx.doi.org/10.1016/j.scitotenv.2024.172689
Vancouver
Campos TGV, Gama WA, Geraldes V, Yoon J, Crnkovic CM, Pinto E, Jacinavicius FR. New records on toxic cyanobacteria from Brazil: exploring their occurrence and geography [Internet]. Science of The Total Environment. 2024 ; 931 1-14 art. 172689.[citado 2024 nov. 16 ] Available from: https://dx.doi.org/10.1016/j.scitotenv.2024.172689
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ALMEIDA, Éryka Costa de et al. Impacts of cyanobacterial metabolites on fish: Socioeconomic and environmental considerations. Reviews in Aquaculture, v. 16, n. 3, p. 1186-1211, 2024Tradução . . Disponível em: https://doi.org/10.1111/raq.12891. Acesso em: 16 nov. 2024.
APA
Almeida, É. C. de, Passos, L. S., Freitas, P. N. N. de, Souza, A. O. de, & Pinto Junior, E. (2024). Impacts of cyanobacterial metabolites on fish: Socioeconomic and environmental considerations. Reviews in Aquaculture, 16( 3), 1186-1211. doi:10.1111/raq.12891
NLM
Almeida ÉC de, Passos LS, Freitas PNN de, Souza AO de, Pinto Junior E. Impacts of cyanobacterial metabolites on fish: Socioeconomic and environmental considerations [Internet]. Reviews in Aquaculture. 2024 ; 16( 3): 1186-1211.[citado 2024 nov. 16 ] Available from: https://doi.org/10.1111/raq.12891
Vancouver
Almeida ÉC de, Passos LS, Freitas PNN de, Souza AO de, Pinto Junior E. Impacts of cyanobacterial metabolites on fish: Socioeconomic and environmental considerations [Internet]. Reviews in Aquaculture. 2024 ; 16( 3): 1186-1211.[citado 2024 nov. 16 ] Available from: https://doi.org/10.1111/raq.12891
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MÉDICE, Rhuana Valdetário et al. Unlocking biological activity and metabolomics insights: primary screening of Cyanobacterial biomass from a tropical reservoir. Environmental Toxicology and Chemistry, v. 43, n. 10, p. 2222-2231, 2024Tradução . . Disponível em: https://doi.org/10.1002/etc.5962. Acesso em: 16 nov. 2024.
APA
Médice, R. V., Arruda, R. S., Yoon, J., Borges, R. M., Noyma, N. P., Lürling, M., et al. (2024). Unlocking biological activity and metabolomics insights: primary screening of Cyanobacterial biomass from a tropical reservoir. Environmental Toxicology and Chemistry, 43( 10), 2222-2231. doi:10.1002/etc.5962
NLM
Médice RV, Arruda RS, Yoon J, Borges RM, Noyma NP, Lürling M, Crnkovic CM, Marinho MM, Pinto E. Unlocking biological activity and metabolomics insights: primary screening of Cyanobacterial biomass from a tropical reservoir [Internet]. Environmental Toxicology and Chemistry. 2024 ; 43( 10): 2222-2231.[citado 2024 nov. 16 ] Available from: https://doi.org/10.1002/etc.5962
Vancouver
Médice RV, Arruda RS, Yoon J, Borges RM, Noyma NP, Lürling M, Crnkovic CM, Marinho MM, Pinto E. Unlocking biological activity and metabolomics insights: primary screening of Cyanobacterial biomass from a tropical reservoir [Internet]. Environmental Toxicology and Chemistry. 2024 ; 43( 10): 2222-2231.[citado 2024 nov. 16 ] Available from: https://doi.org/10.1002/etc.5962
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SILVA, Thalita Tieko et al. Intracellular microcystins degradation and acute toxicity decrease towards Daphnia similis by low electron-beam irradiation doses. Algal Research, v. 72, 2023Tradução . . Disponível em: https://doi.org/10.1016/j.algal.2023.103086. Acesso em: 16 nov. 2024.
APA
Silva, T. T., Jacinavicius, F. R., Pinto, E., & Borrely, S. I. (2023). Intracellular microcystins degradation and acute toxicity decrease towards Daphnia similis by low electron-beam irradiation doses. Algal Research, 72. doi:10.1016/j.algal.2023.103086
NLM
Silva TT, Jacinavicius FR, Pinto E, Borrely SI. Intracellular microcystins degradation and acute toxicity decrease towards Daphnia similis by low electron-beam irradiation doses [Internet]. Algal Research. 2023 ; 72[citado 2024 nov. 16 ] Available from: https://doi.org/10.1016/j.algal.2023.103086
Vancouver
Silva TT, Jacinavicius FR, Pinto E, Borrely SI. Intracellular microcystins degradation and acute toxicity decrease towards Daphnia similis by low electron-beam irradiation doses [Internet]. Algal Research. 2023 ; 72[citado 2024 nov. 16 ] Available from: https://doi.org/10.1016/j.algal.2023.103086
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PASSOS, Larissa Souza et al. Ecotoxicological assessment of guanitoxin-producing cyanobacteria in Danio rerio and Daphnia similis. Chemosphere, v. 332, p. 1-12. 2023, 2023Tradução . . Disponível em: https://doi.org/10.1016/j.chemosphere.2023.138846. Acesso em: 16 nov. 2024.
APA
Passos, L. S., Jacinavicius, F. R., Geraldes, V. S. M., Freitas, P. N. N. de, Silva, G. H. D., Almeida, É. C. de, et al. (2023). Ecotoxicological assessment of guanitoxin-producing cyanobacteria in Danio rerio and Daphnia similis. Chemosphere, 332, 1-12. 2023. doi:10.1016/j.chemosphere.2023.138846
NLM
Passos LS, Jacinavicius FR, Geraldes VSM, Freitas PNN de, Silva GHD, Almeida ÉC de, Alves AP do C, Orlando TM, Cerozi B da S, Martinez DST, Pinto E. Ecotoxicological assessment of guanitoxin-producing cyanobacteria in Danio rerio and Daphnia similis [Internet]. Chemosphere. 2023 ; 332 1-12. 2023.[citado 2024 nov. 16 ] Available from: https://doi.org/10.1016/j.chemosphere.2023.138846
Vancouver
Passos LS, Jacinavicius FR, Geraldes VSM, Freitas PNN de, Silva GHD, Almeida ÉC de, Alves AP do C, Orlando TM, Cerozi B da S, Martinez DST, Pinto E. Ecotoxicological assessment of guanitoxin-producing cyanobacteria in Danio rerio and Daphnia similis [Internet]. Chemosphere. 2023 ; 332 1-12. 2023.[citado 2024 nov. 16 ] Available from: https://doi.org/10.1016/j.chemosphere.2023.138846
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FREITAS, Paloma Nathane Nunes de et al. Evaluation of the toxicity of microcyclamide produced by Microcystis aeruginosa in Danio rerio embryos. Toxics, v. 11, p. 1- 11, 2023Tradução . . Disponível em: https://doi.org/10.3390/toxics11020128. Acesso em: 16 nov. 2024.
APA
Freitas, P. N. N. de, Teramoto, K. K., Souza, A. O. de, & Pinto, E. (2023). Evaluation of the toxicity of microcyclamide produced by Microcystis aeruginosa in Danio rerio embryos. Toxics, 11, 1- 11. doi:10.3390/toxics11020128
NLM
Freitas PNN de, Teramoto KK, Souza AO de, Pinto E. Evaluation of the toxicity of microcyclamide produced by Microcystis aeruginosa in Danio rerio embryos [Internet]. Toxics. 2023 ; 11 1- 11.[citado 2024 nov. 16 ] Available from: https://doi.org/10.3390/toxics11020128
Vancouver
Freitas PNN de, Teramoto KK, Souza AO de, Pinto E. Evaluation of the toxicity of microcyclamide produced by Microcystis aeruginosa in Danio rerio embryos [Internet]. Toxics. 2023 ; 11 1- 11.[citado 2024 nov. 16 ] Available from: https://doi.org/10.3390/toxics11020128
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JACINAVICIUS, Fernanda Rios et al. Toxicological effects of cyanobacterial metabolites on zebrafish larval development. Harmful Algae, v. 125, p. 1-16 art. 102430, 2023Tradução . . Disponível em: https://doi.org/10.1016/j.hal.2023.102430. Acesso em: 16 nov. 2024.
APA
Jacinavicius, F. R., Geraldes, V., Fernandes, K. A., Crnkovic, C. M., Gama, W. A., & Pinto, E. (2023). Toxicological effects of cyanobacterial metabolites on zebrafish larval development. Harmful Algae, 125, 1-16 art. 102430. doi:10.1016/j.hal.2023.102430
NLM
Jacinavicius FR, Geraldes V, Fernandes KA, Crnkovic CM, Gama WA, Pinto E. Toxicological effects of cyanobacterial metabolites on zebrafish larval development [Internet]. Harmful Algae. 2023 ; 125 1-16 art. 102430.[citado 2024 nov. 16 ] Available from: https://doi.org/10.1016/j.hal.2023.102430
Vancouver
Jacinavicius FR, Geraldes V, Fernandes KA, Crnkovic CM, Gama WA, Pinto E. Toxicological effects of cyanobacterial metabolites on zebrafish larval development [Internet]. Harmful Algae. 2023 ; 125 1-16 art. 102430.[citado 2024 nov. 16 ] Available from: https://doi.org/10.1016/j.hal.2023.102430
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TORRES, Mariana de Almeida et al. Lethal and sublethal effects towards zebrafish larvae of microcystins and other cyanopeptides produced by cyanobacteria. Aquatic Toxicology, v. 263, 2023Tradução . . Disponível em: https://doi.org/10.1016/j.aquatox.2023.106689. Acesso em: 16 nov. 2024.
APA
Torres, M. de A., Jones, M. R., vom Berg, C., Pinto, E., & Janssen, E. M. -L. (2023). Lethal and sublethal effects towards zebrafish larvae of microcystins and other cyanopeptides produced by cyanobacteria. Aquatic Toxicology, 263. doi:10.1016/j.aquatox.2023.106689
NLM
Torres M de A, Jones MR, vom Berg C, Pinto E, Janssen EM-L. Lethal and sublethal effects towards zebrafish larvae of microcystins and other cyanopeptides produced by cyanobacteria [Internet]. Aquatic Toxicology. 2023 ; 263[citado 2024 nov. 16 ] Available from: https://doi.org/10.1016/j.aquatox.2023.106689
Vancouver
Torres M de A, Jones MR, vom Berg C, Pinto E, Janssen EM-L. Lethal and sublethal effects towards zebrafish larvae of microcystins and other cyanopeptides produced by cyanobacteria [Internet]. Aquatic Toxicology. 2023 ; 263[citado 2024 nov. 16 ] Available from: https://doi.org/10.1016/j.aquatox.2023.106689
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WEISS, Márcio Barczyszyn et al. Metabolomics applied to cyanobacterial toxins and natural products. Microbial Natural Products: A Metabolomics Approach. Tradução . Cham: Springer, 2023. . . Acesso em: 16 nov. 2024.
APA
Weiss, M. B., Médice, R. V., Jacinavicius, F. R., Pinto, E., & Crnkovic, C. M. (2023). Metabolomics applied to cyanobacterial toxins and natural products. In Microbial Natural Products: A Metabolomics Approach. Cham: Springer.
NLM
Weiss MB, Médice RV, Jacinavicius FR, Pinto E, Crnkovic CM. Metabolomics applied to cyanobacterial toxins and natural products. In: Microbial Natural Products: A Metabolomics Approach. Cham: Springer; 2023. [citado 2024 nov. 16 ]
Vancouver
Weiss MB, Médice RV, Jacinavicius FR, Pinto E, Crnkovic CM. Metabolomics applied to cyanobacterial toxins and natural products. In: Microbial Natural Products: A Metabolomics Approach. Cham: Springer; 2023. [citado 2024 nov. 16 ]
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JACINAVICIUS, Fernanda Rios et al. A rapid LC-MS/MS method for multi-class identification and quantification of cyanotoxins. Toxicon, v. 234, 2023Tradução . . Disponível em: https://doi.org/10.1016/j.toxicon.2023.107282. Acesso em: 16 nov. 2024.
APA
Jacinavicius, F. R., Campos, T. G. V., Passos, L. S., Pinto, E., & Geraldes, V. (2023). A rapid LC-MS/MS method for multi-class identification and quantification of cyanotoxins. Toxicon, 234. doi:10.1016/j.toxicon.2023.107282
NLM
Jacinavicius FR, Campos TGV, Passos LS, Pinto E, Geraldes V. A rapid LC-MS/MS method for multi-class identification and quantification of cyanotoxins [Internet]. Toxicon. 2023 ; 234[citado 2024 nov. 16 ] Available from: https://doi.org/10.1016/j.toxicon.2023.107282
Vancouver
Jacinavicius FR, Campos TGV, Passos LS, Pinto E, Geraldes V. A rapid LC-MS/MS method for multi-class identification and quantification of cyanotoxins [Internet]. Toxicon. 2023 ; 234[citado 2024 nov. 16 ] Available from: https://doi.org/10.1016/j.toxicon.2023.107282
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MORETTO, Jéssica Aparecida Silva et al. Effects of different cultivation conditions on the production of β-cyclocitral and β-ionone in Microcystis aeruginosa. BMC Microbiology, v. 22, p. 1-13, 2022Tradução . . Disponível em: https://doi.org/10.1186/s12866-022-02473-6. Acesso em: 16 nov. 2024.
APA
Moretto, J. A. S., Freitas, P. N. N. de, Almeida, É. C. de, Altarugio, L. M., Silva, S. V. da, Fiore, M. de F., & Pinto, E. (2022). Effects of different cultivation conditions on the production of β-cyclocitral and β-ionone in Microcystis aeruginosa. BMC Microbiology, 22, 1-13. doi:10.1186/s12866-022-02473-6
NLM
Moretto JAS, Freitas PNN de, Almeida ÉC de, Altarugio LM, Silva SV da, Fiore M de F, Pinto E. Effects of different cultivation conditions on the production of β-cyclocitral and β-ionone in Microcystis aeruginosa [Internet]. BMC Microbiology. 2022 ; 22 1-13.[citado 2024 nov. 16 ] Available from: https://doi.org/10.1186/s12866-022-02473-6
Vancouver
Moretto JAS, Freitas PNN de, Almeida ÉC de, Altarugio LM, Silva SV da, Fiore M de F, Pinto E. Effects of different cultivation conditions on the production of β-cyclocitral and β-ionone in Microcystis aeruginosa [Internet]. BMC Microbiology. 2022 ; 22 1-13.[citado 2024 nov. 16 ] Available from: https://doi.org/10.1186/s12866-022-02473-6
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LOPES, Taciana Onesorge Miranda et al. Off-flavor detection in tilapia reared in cages in tropical lakes. Aquaculture, n. , p. 738215-, 2022Tradução . . Disponível em: https://doi.org/10.1016/j.aquaculture.2022.738215. Acesso em: 16 nov. 2024.
APA
Lopes, T. O. M., Pinto, E., Passos, L. S., Dörr, F., Vasconcelos, C. M., Arpini, C., et al. (2022). Off-flavor detection in tilapia reared in cages in tropical lakes. Aquaculture, ( ), 738215-. doi:10.1016/j.aquaculture.2022.738215
NLM
Lopes TOM, Pinto E, Passos LS, Dörr F, Vasconcelos CM, Arpini C, Silva MO, Pereira TM, Coppo GC, Merçon J, Gomes LC. Off-flavor detection in tilapia reared in cages in tropical lakes [Internet]. Aquaculture. 2022 ;( ): 738215-.[citado 2024 nov. 16 ] Available from: https://doi.org/10.1016/j.aquaculture.2022.738215
Vancouver
Lopes TOM, Pinto E, Passos LS, Dörr F, Vasconcelos CM, Arpini C, Silva MO, Pereira TM, Coppo GC, Merçon J, Gomes LC. Off-flavor detection in tilapia reared in cages in tropical lakes [Internet]. Aquaculture. 2022 ;( ): 738215-.[citado 2024 nov. 16 ] Available from: https://doi.org/10.1016/j.aquaculture.2022.738215
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MORETTO, Jéssica Aparecida Silva et al. Microwave-assisted extraction of fatty acids from cultured and commercial phytoplankton species. Applied Sciences, v. 12, p. 2407, 2022Tradução . . Disponível em: https://doi.org/10.3390/app12052407. Acesso em: 16 nov. 2024.
APA
Moretto, J. A. S., Souza, A. O. de, Berneira, L. M., Brigagão, L. G. G., Pereira, C. M. P. de, Converti, A., & Pinto, E. (2022). Microwave-assisted extraction of fatty acids from cultured and commercial phytoplankton species. Applied Sciences, 12, 2407. doi:10.3390/app12052407
NLM
Moretto JAS, Souza AO de, Berneira LM, Brigagão LGG, Pereira CMP de, Converti A, Pinto E. Microwave-assisted extraction of fatty acids from cultured and commercial phytoplankton species [Internet]. Applied Sciences. 2022 ; 12 2407.[citado 2024 nov. 16 ] Available from: https://doi.org/10.3390/app12052407
Vancouver
Moretto JAS, Souza AO de, Berneira LM, Brigagão LGG, Pereira CMP de, Converti A, Pinto E. Microwave-assisted extraction of fatty acids from cultured and commercial phytoplankton species [Internet]. Applied Sciences. 2022 ; 12 2407.[citado 2024 nov. 16 ] Available from: https://doi.org/10.3390/app12052407
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PASSOS, Larissa Souza et al. Cyanotoxins and water quality parameters as risk assessment indicators for aquatic life in reservoirs. Ecotoxicology and Environmental Safety, v. 241, 2022Tradução . . Disponível em: https://doi.org/10.1016/j.ecoenv.2022.113828. Acesso em: 16 nov. 2024.
APA
Passos, L. S., de Almeida, É. C., Villela, A., Fernandes, A. N., Marinho, M. M., Gomes, L. C., & Pinto, E. (2022). Cyanotoxins and water quality parameters as risk assessment indicators for aquatic life in reservoirs. Ecotoxicology and Environmental Safety, 241. doi:10.1016/j.ecoenv.2022.113828
NLM
Passos LS, de Almeida ÉC, Villela A, Fernandes AN, Marinho MM, Gomes LC, Pinto E. Cyanotoxins and water quality parameters as risk assessment indicators for aquatic life in reservoirs [Internet]. Ecotoxicology and Environmental Safety. 2022 ;241[citado 2024 nov. 16 ] Available from: https://doi.org/10.1016/j.ecoenv.2022.113828
Vancouver
Passos LS, de Almeida ÉC, Villela A, Fernandes AN, Marinho MM, Gomes LC, Pinto E. Cyanotoxins and water quality parameters as risk assessment indicators for aquatic life in reservoirs [Internet]. Ecotoxicology and Environmental Safety. 2022 ;241[citado 2024 nov. 16 ] Available from: https://doi.org/10.1016/j.ecoenv.2022.113828
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FRANCO, Bernadette Dora Gombossy de Melo et al. Desafios da segurança alimentar global e equilíbrio ambiental. FAPESP 60 anos : a ciência no desenvolvimento nacional. Tradução . São Carlos: Cubo, 2022. . Disponível em: https://doi.org/10.4322/978-65-86819-27-4. Acesso em: 16 nov. 2024.
APA
Franco, B. D. G. de M., Rech Filho, E. L., Rodrigues, R., Costa, M. H., & Mendes, L. W. (2022). Desafios da segurança alimentar global e equilíbrio ambiental. In FAPESP 60 anos : a ciência no desenvolvimento nacional. São Carlos: Cubo. doi:10.4322/978-65-86819-27-4
NLM
Franco BDG de M, Rech Filho EL, Rodrigues R, Costa MH, Mendes LW. Desafios da segurança alimentar global e equilíbrio ambiental [Internet]. In: FAPESP 60 anos : a ciência no desenvolvimento nacional. São Carlos: Cubo; 2022. [citado 2024 nov. 16 ] Available from: https://doi.org/10.4322/978-65-86819-27-4
Vancouver
Franco BDG de M, Rech Filho EL, Rodrigues R, Costa MH, Mendes LW. Desafios da segurança alimentar global e equilíbrio ambiental [Internet]. In: FAPESP 60 anos : a ciência no desenvolvimento nacional. São Carlos: Cubo; 2022. [citado 2024 nov. 16 ] Available from: https://doi.org/10.4322/978-65-86819-27-4
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MACHADO, Leila dos Santos et al. Permanent occurrence of Raphidiopsis raciborskii and cyanotoxins in a subtropical reservoir polluted by domestic efuents (Itupararanga reservoir, São Paulo, Brazil). Environmental Science and Pollution Research International, v. 29, p. 18653-18664, 2022Tradução . . Disponível em: https://doi.org/10.1007/s11356-021-16994-6. Acesso em: 16 nov. 2024.
APA
Machado, L. dos S., Dörr, F., Dörr, F. A., Frascareli, D., Melo, D. S., Gontijo, E. S. J., et al. (2022). Permanent occurrence of Raphidiopsis raciborskii and cyanotoxins in a subtropical reservoir polluted by domestic efuents (Itupararanga reservoir, São Paulo, Brazil). Environmental Science and Pollution Research International, 29, 18653-18664. doi:10.1007/s11356-021-16994-6
NLM
Machado L dos S, Dörr F, Dörr FA, Frascareli D, Melo DS, Gontijo ESJ, Friese K, Pinto E, Rosa AH, Pompêo M, Carlos VM. Permanent occurrence of Raphidiopsis raciborskii and cyanotoxins in a subtropical reservoir polluted by domestic efuents (Itupararanga reservoir, São Paulo, Brazil) [Internet]. Environmental Science and Pollution Research International. 2022 ; 29 18653-18664.[citado 2024 nov. 16 ] Available from: https://doi.org/10.1007/s11356-021-16994-6
Vancouver
Machado L dos S, Dörr F, Dörr FA, Frascareli D, Melo DS, Gontijo ESJ, Friese K, Pinto E, Rosa AH, Pompêo M, Carlos VM. Permanent occurrence of Raphidiopsis raciborskii and cyanotoxins in a subtropical reservoir polluted by domestic efuents (Itupararanga reservoir, São Paulo, Brazil) [Internet]. Environmental Science and Pollution Research International. 2022 ; 29 18653-18664.[citado 2024 nov. 16 ] Available from: https://doi.org/10.1007/s11356-021-16994-6