Injectable mineral supplementation during the transition period reduces uterine disease and hypocalcemia and enhances humoral immunity in holstein dairy cows (2026)
- Authors:
- USP affiliated authors: The transition period in dairy cows is marked by metabolic, oxidative, and immune challenges that increase susceptibility to periparturient diseases. Injectable mineral supple- mentation (IMS) has been proposed to support immunometabolic adaptation by enhancing antioxidant capacity and immune function, with consistent associations with improved health outcomes but variable effects on production. Therefore, this study evaluated the effects of repeated intramuscular multi-mineral supplementation during the transition period on health, metabolic stress, immune status, and productive performance in Holstein cows. Supplementation was associated with lower odds of subclinical hypocalcemia on day 4 postpartum in primiparous cows (p = 0.02) and overall for persistent subclinical hypocalcemia (p = 0.03). Multiparous cows (p = 0.04) and the overall population (p = 0.01) showed consistent effects on metritis following IMS. Supplemented cows had improved metabolic and uterine health indicators without affecting energy metabolism-related dis- orders. Although no differences were detected for major postpartum health disorders, its main benefits may involve immune competence, oxidative regulation, and physiological resilience rather than energy balance - ; MARQUES, RAQUEL DE SOUSA - FMVZ ; PINHEIRO, FILIPE AGUERA - FMVZ ; MORI, CLARA SATSUKI - FMVZ ; RETAMOZO, SUSAN ESMERALDA SUAREZ - FMVZ ; BUSANELLO, MARCOS - ESALQ ; GOMES, VIVIANI - FMVZ
- Unidades: FMVZ; ESALQ
- DOI: 10.3390/ani16060956
- Subjects: DOENÇAS UTERINAS; GADO HOLANDÊS; IMUNIDADE; METABOLISMO ANIMAL; PARTO EM ANIMAL; SUPLEMENTOS MINERAIS PARA ANIMAIS; VACAS
- Agências de fomento:
- Language: Inglês
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- Status:
- Artigo publicado em periódico de acesso aberto (Gold Open Access)
- Versão do Documento:
- Versão publicada (Published version)
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ABNT
MARQUES, Raquel de Sousa et al. Injectable mineral supplementation during the transition period reduces uterine disease and hypocalcemia and enhances humoral immunity in holstein dairy cows. Animals, v. 16, p. 1-18, 2026Tradução . . Disponível em: https://doi.org/10.3390/ani16060956. Acesso em: 16 abr. 2026. -
APA
Marques, R. de S., Pinheiro, F. A., Mori, C. S., Suárez-Retamozo, S. E., Busanello, M., Almeida, R. de, et al. (2026). Injectable mineral supplementation during the transition period reduces uterine disease and hypocalcemia and enhances humoral immunity in holstein dairy cows. Animals, 16, 1-18. doi:10.3390/ani16060956 -
NLM
Marques R de S, Pinheiro FA, Mori CS, Suárez-Retamozo SE, Busanello M, Almeida R de, Lima BS, Durel L, Gomes V. Injectable mineral supplementation during the transition period reduces uterine disease and hypocalcemia and enhances humoral immunity in holstein dairy cows [Internet]. Animals. 2026 ; 16 1-18.[citado 2026 abr. 16 ] Available from: https://doi.org/10.3390/ani16060956 -
Vancouver
Marques R de S, Pinheiro FA, Mori CS, Suárez-Retamozo SE, Busanello M, Almeida R de, Lima BS, Durel L, Gomes V. Injectable mineral supplementation during the transition period reduces uterine disease and hypocalcemia and enhances humoral immunity in holstein dairy cows [Internet]. Animals. 2026 ; 16 1-18.[citado 2026 abr. 16 ] Available from: https://doi.org/10.3390/ani16060956 - Abomasal bloat in Holstein calf
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