The hydrogen sulfide donor 4-carboxyphenyl-isothiocyanate decreases blood pressure and promotes cardioprotective effect through reduction of oxidative stress and nuclear factor kappa B/matrix metalloproteinase (MMP)-2 axis in hypertension (2024)
- Authors:
- Pernomian, Laena

- Mello, Marcela Maria Blascke de

- Parente, Juliana Montenegro

- Sanches-Lopes, Jéssica Maria

- Tanus-Santos, José Eduardo

- Silva, Luciana Tabajara Parreiras e
- Antunes-Rodrigues, José

- Santos, Raoni da Conceição dos

- Elias, Lucila Leico Kagohara

- Fabro, Alexandre Todorovic

- Silva, Carlos Alberto Aguiar da
- Fazan Júnior, Rubens

- Castro, Michele Mazzaron de

- Pernomian, Laena
- USP affiliated authors: SANTOS, JOSE EDUARDO TANUS DOS - FMRP ; RODRIGUES, JOSE ANTUNES - FMRP ; ELIAS, LUCILA LEICO KAGOHARA - FMRP ; FABRO, ALEXANDRE TODOROVIC - FMRP ; SILVA, CARLOS ALBERTO AGUIAR DA - FMRP ; FAZAN JÚNIOR, RUBENS - FMRP ; CASTRO, MICHELE MAZZARON DE - FMRP ; PERNOMIAN, LAENA - FMRP ; MELLO, MARCELA MARIA BLASCKE DE - FMRP ; PARENTE, JULIANA MONTENEGRO - FMRP ; LOPES, JÉSSICA MARIA SANCHES - FMRP ; SILVA, LUCIANA TABAJARA PARREIRAS E - FMRP ; SANTOS, RAONI DA CONCEIÇÃO DOS - FMRP
- Unidade: FMRP
- DOI: /10.1016/j.lfs.2024.122819
- Subjects: PRESSÃO SANGUÍNEA; HIPERTENSÃO; FARMACOTERAPIA; ESTRESSE OXIDATIVO; ANIMAIS DE LABORATÓRIO
- Keywords: Hypertension; Hydrogen sulfide (H2S) donors; Cardiac dysfunction; Cardiac hypertrophic remodeling; Matrix metalloproteinase 2 (MMP-2)
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher place: Philadelphia
- Date published: 2024
- Source:
- Título: Life Sciences
- ISSN: 0024-3205
- Volume/Número/Paginação/Ano: v. 351, art. 122819, p. 1-14, 2024
- Este periódico é de acesso aberto
- Este artigo NÃO é de acesso aberto
-
ABNT
PERNOMIAN, Laena et al. The hydrogen sulfide donor 4-carboxyphenyl-isothiocyanate decreases blood pressure and promotes cardioprotective effect through reduction of oxidative stress and nuclear factor kappa B/matrix metalloproteinase (MMP)-2 axis in hypertension. Life Sciences, v. 351, p. 1-14, 2024Tradução . . Disponível em: https://doi.org//10.1016/j.lfs.2024.122819. Acesso em: 10 fev. 2026. -
APA
Pernomian, L., Mello, M. M. B. de, Parente, J. M., Sanches-Lopes, J. M., Tanus-Santos, J. E., Silva, L. T. P. e, et al. (2024). The hydrogen sulfide donor 4-carboxyphenyl-isothiocyanate decreases blood pressure and promotes cardioprotective effect through reduction of oxidative stress and nuclear factor kappa B/matrix metalloproteinase (MMP)-2 axis in hypertension. Life Sciences, 351, 1-14. doi:/10.1016/j.lfs.2024.122819 -
NLM
Pernomian L, Mello MMB de, Parente JM, Sanches-Lopes JM, Tanus-Santos JE, Silva LTP e, Antunes-Rodrigues J, Santos R da C dos, Elias LLK, Fabro AT, Silva CAA da, Fazan Júnior R, Castro MM de. The hydrogen sulfide donor 4-carboxyphenyl-isothiocyanate decreases blood pressure and promotes cardioprotective effect through reduction of oxidative stress and nuclear factor kappa B/matrix metalloproteinase (MMP)-2 axis in hypertension [Internet]. Life Sciences. 2024 ; 351 1-14.[citado 2026 fev. 10 ] Available from: https://doi.org//10.1016/j.lfs.2024.122819 -
Vancouver
Pernomian L, Mello MMB de, Parente JM, Sanches-Lopes JM, Tanus-Santos JE, Silva LTP e, Antunes-Rodrigues J, Santos R da C dos, Elias LLK, Fabro AT, Silva CAA da, Fazan Júnior R, Castro MM de. The hydrogen sulfide donor 4-carboxyphenyl-isothiocyanate decreases blood pressure and promotes cardioprotective effect through reduction of oxidative stress and nuclear factor kappa B/matrix metalloproteinase (MMP)-2 axis in hypertension [Internet]. Life Sciences. 2024 ; 351 1-14.[citado 2026 fev. 10 ] Available from: https://doi.org//10.1016/j.lfs.2024.122819 - Matrix metalloproteinase (MMP)-2 activation by oxidative stress decreases aortic calponin-1 levels during hypertrophic remodeling in early hypertension
- Sodium hydrogen sulfide improves renovascular hypertension-induced maladaptive cardiac remodeling and diastolic dysfunction by reducing oxidative stress and mmp activity
- Arterial hypertension may involve sarcoplasmic reticulum calcium atpase (serca) proteolysis by matrix metalloproteinase (mmp)-2
- AMPA and angiotensin type 1 receptors are necessary for hemorrhage-induced vasopressin secretion
- The role of matrix metalloproteinase (MMP)-2 to type I collagen turnover contributing to hypertrophic arterial remodeling in renovascular hypertension
- Mmp-2 inhibition attenuates hypertensive eccentric cardiac hypertrophy and dysfunction by preserving troponin I and dystrophin
- MMP inhibition attenuates hypertensive eccentric cardiac hypertrophy and dysfunction by preserving troponin I and dystrophin
- Matrix metalloproteinase in the cardiovascular remodeling of hypertension: current insights and therapeutic potential
- Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats
- Matrix metalloproteinase (MMP)-2 decreases calponin-1 levels and contributes to arterial remodeling in early hypertension
Informações sobre o DOI: /10.1016/j.lfs.2024.122819 (Fonte: oaDOI API)
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