Complement C3 deficiency enhances renal leptospiral load and inflammation while impairing T cell differentiation during chronic Leptospira interrogans infection (2025)
- Authors:
- USP affiliated authors: DUARTE NETO, AMARO NUNES - FM ; SILVA, ANA MARIA GONÇALVES DA - FM ; HEINEMANN, MARCOS BRYAN - FMVZ ; ISAAC, LOURDES - ICB ; MIDON, LEONARDO MOURA - ICB
- Unidades: FM; FMVZ; ICB
- DOI: 10.1128/iai.00398-25
- Subjects: IMUNOLOGIA; IMUNOPROTEÍNAS; LEPTOSPIROSE; MATRIZ EXTRACELULAR; NEFROPATIAS; LEPTOSPIROSE ANIMAL; CAMUNDONGOS; LINFÓCITOS T; INFLAMAÇÃO; MODELOS ANIMAIS DE DOENÇAS; RIM; DIFERENCIAÇÃO CELULAR
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher place: Washington
- Date published: 2025
- Source:
- Título: Infection and Immunity
- ISSN: 1098-5522
- Volume/Número/Paginação/Ano: v. 93, art. e00398-25, 18 p., 2025
- Status:
- Artigo publicado em periódico de acesso aberto (Gold Open Access)
- Versão do Documento:
- Versão publicada (Published version)
- Acessar versão aberta:
-
ABNT
MIDON, Leonardo Moura et al. Complement C3 deficiency enhances renal leptospiral load and inflammation while impairing T cell differentiation during chronic Leptospira interrogans infection. Infection and Immunity, v. 93, p. 18 , 2025Tradução . . Disponível em: https://doi.org/10.1128/iai.00398-25. Acesso em: 07 maio 2026. -
APA
Midon, L. M., Duarte Neto, A. N., Silva, A. M. G. da, Heinemann, M. B., Kundu, S., Gomes-Solecki, M., & Isaac, L. (2025). Complement C3 deficiency enhances renal leptospiral load and inflammation while impairing T cell differentiation during chronic Leptospira interrogans infection. Infection and Immunity, 93, 18 . doi:10.1128/iai.00398-25 -
NLM
Midon LM, Duarte Neto AN, Silva AMG da, Heinemann MB, Kundu S, Gomes-Solecki M, Isaac L. Complement C3 deficiency enhances renal leptospiral load and inflammation while impairing T cell differentiation during chronic Leptospira interrogans infection [Internet]. Infection and Immunity. 2025 ; 93 18 .[citado 2026 maio 07 ] Available from: https://doi.org/10.1128/iai.00398-25 -
Vancouver
Midon LM, Duarte Neto AN, Silva AMG da, Heinemann MB, Kundu S, Gomes-Solecki M, Isaac L. Complement C3 deficiency enhances renal leptospiral load and inflammation while impairing T cell differentiation during chronic Leptospira interrogans infection [Internet]. Infection and Immunity. 2025 ; 93 18 .[citado 2026 maio 07 ] Available from: https://doi.org/10.1128/iai.00398-25 - Proteolytic activity of secreted proteases from pathogenic leptospires and effects on phagocytosis by murine macrophages
- Assessing the role of the complement system in the elimination of Leptospira SPP
- Leptospira interrogans secreted proteases degrade extracellular matrix and plasma proteins from the host
- Murine C3 of the complement system affects infection by Leptospira interrogans
- Role of murine complement component C5 in acute in vivo infection by pathogenic Leptospira interrogans
- Proteolytic activity of secreted proteases from pathogenic leptospires and effects on phagocytosis by murine macrophages
- Contribution of complement system pathways to the killing of Leptospira spp
- Complement factor H polymorphisms in leptospirosis patients
- Role of p21 and oxidative stress on renal tubular resistance after acute ischaemic injury
- Pathology and pathogenesis of human leptospirosis: a commented review
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