Novel dual AChE and ROCK2 inhibitor induces neurogenesis via PTEN/AKT pathway in Alzheimer’s disease model (2022)
- Authors:
- USP affiliated authors: MOREIRA, NATALIA CHERMONT DOS SANTOS - FMRP ; LIMA, JÉSSICA ELLEN BARBOSA DE FREITAS - FMRP ; CARVALHO, IVONE - FCFRP ; PASSOS JUNIOR, GERALDO ALEIXO DA SILVA - FORP ; HOJO, ELZA TIEMI SAKAMOTO - FFCLRP ; TAMAROZZI, ELVIRA REGINA - EACH ; PIASSI, LARISSA DE OLIVEIRA - FMRP
- Unidades: FMRP; FCFRP; FORP; FFCLRP; EACH
- DOI: 10.3390/ijms232314788
- Subjects: ENZIMAS; ACETILCOLINA; NEUROTRANSMISSORES; SISTEMA NERVOSO
- Keywords: Neurodifferentiation; Neurite outgrowth; Molecular docking; Multi-target; Cholinesterase activity
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: International Journal of Molecular Sciences
- ISSN: 1422-0067
- Volume/Número/Paginação/Ano: v. 23, n. 23, art. 14788, p. 1-22, 2022
- Este artigo possui versão em acesso aberto
- URL de acesso aberto
- PDF de acesso aberto
- Versão do Documento: Versão publicada (Published version)
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Status: Artigo publicado em periódico de acesso aberto (Gold Open Access) -
ABNT
MOREIRA, Natália Chermont dos Santos et al. Novel dual AChE and ROCK2 inhibitor induces neurogenesis via PTEN/AKT pathway in Alzheimer’s disease model. International Journal of Molecular Sciences, v. 23, n. 23, p. 1-22, 2022Tradução . . Disponível em: https://doi.org/10.3390/ijms232314788. Acesso em: 14 mar. 2026. -
APA
Moreira, N. C. dos S., Tamarozzi, E. R., Lima, J. E. B. de F., Piassi, L. de O., Carvalho, I., Passos, G. A. S., & Sakamoto-Hojo, E. T. (2022). Novel dual AChE and ROCK2 inhibitor induces neurogenesis via PTEN/AKT pathway in Alzheimer’s disease model. International Journal of Molecular Sciences, 23( 23), 1-22. doi:10.3390/ijms232314788 -
NLM
Moreira NC dos S, Tamarozzi ER, Lima JEB de F, Piassi L de O, Carvalho I, Passos GAS, Sakamoto-Hojo ET. Novel dual AChE and ROCK2 inhibitor induces neurogenesis via PTEN/AKT pathway in Alzheimer’s disease model [Internet]. International Journal of Molecular Sciences. 2022 ; 23( 23): 1-22.[citado 2026 mar. 14 ] Available from: https://doi.org/10.3390/ijms232314788 -
Vancouver
Moreira NC dos S, Tamarozzi ER, Lima JEB de F, Piassi L de O, Carvalho I, Passos GAS, Sakamoto-Hojo ET. Novel dual AChE and ROCK2 inhibitor induces neurogenesis via PTEN/AKT pathway in Alzheimer’s disease model [Internet]. International Journal of Molecular Sciences. 2022 ; 23( 23): 1-22.[citado 2026 mar. 14 ] Available from: https://doi.org/10.3390/ijms232314788 - Novel AChE and ROCK dual inhibitor designed for Alzheimer's disease therapy promotes neurodifferentiation and neuritogenesis in SHSY5Y cells
- Novel hybrid acetylcholinesterase inhibitors induce differentiation and neuritogenesis in neuronal cells in vitro through activation of the AKT pathway
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- PARP-1 inhibition does not protect neuronal-like and primary neural progenitor cells against in vitro induced-oxidative damage
- Mechanisms underlying the pathophysiology of type 2 diabetes: from risk factors to oxidative stress, metabolic dysfunction, and hyperglycemia
- Oxidative stress, DNA damage, and transcriptional expression of DNA repair and stress response genes in diabetes mellitus
- Neuroprotective effects of cholinesterase inhibitors: current scenario in therapies for Alzheimer’s disease and future perspectives
- NRF2 activation as a potential strategy to enhance neuronal survival under the exposure to oxidative stress
- Neuroprotective effect of acetylcholinesterase inhibitors in response to oxidative stress in neuronal SH-SY5Y cell line
- Brain organoids as a neuronal model applied in neuroscience and neurodegenerative diseases
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