Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors (2025)
- Authors:
- USP affiliated authors: OLIVA, GLAUCIUS - IFSC ; GODOY, ANDRE SCHÜTZER DE - IFSC ; DOLCI, ISABELA - IFSC ; FERNANDES, RAFAELA SACHETTO - IFSC
- Unidade: IFSC
- DOI: 10.1038/s41467-025-63602-z
- Subjects: ZIKA VÍRUS; VÍRUS; DENGUE; BIOFÍSICA
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: Nature Communications
- ISSN: 2041-1723
- Volume/Número/Paginação/Ano: v. 16, p. 8930-1-8930-13 + supplementary information, Oct. 2025
- Este periódico é de acesso aberto
- Este artigo NÃO é de acesso aberto
-
ABNT
NI, Xiaomin et al. Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors. Nature Communications, v. 16, p. 8930-1-8930-13 + supplementary information, 2025Tradução . . Disponível em: https://doi.org/10.1038/s41467-025-63602-z. Acesso em: 10 fev. 2026. -
APA
Ni, X., Godoy, A. S. de, Dolci, I., Fernandes, R. S., & Oliva, G. (2025). Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors. Nature Communications, 16, 8930-1-8930-13 + supplementary information. doi:10.1038/s41467-025-63602-z -
NLM
Ni X, Godoy AS de, Dolci I, Fernandes RS, Oliva G. Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors [Internet]. Nature Communications. 2025 ; 16 8930-1-8930-13 + supplementary information.[citado 2026 fev. 10 ] Available from: https://doi.org/10.1038/s41467-025-63602-z -
Vancouver
Ni X, Godoy AS de, Dolci I, Fernandes RS, Oliva G. Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors [Internet]. Nature Communications. 2025 ; 16 8930-1-8930-13 + supplementary information.[citado 2026 fev. 10 ] Available from: https://doi.org/10.1038/s41467-025-63602-z - Identification of pan-flavivirus compounds from drug repurposing
- Descoberta de candidatos antivirais contra a protease nsP2pro de Chikungunya
- Identification of potent inhibitors of Zika and Dengue viruses proteases from smallmolecule compound libraries
- Reporter replicon systems for the screening of potential antiviral agents against zika, yellow fever and chikungunya viruses
- The protein disulfide isomerase inhibitor 3-methyltoxoflavin inhibits Chikungunya virus
- The Antifungal itraconazole is a potent inhibitor of Chikungunya virus replication
- Naphthyridine-derived compound effectively inhibits the early stages of CHIKV virus infection in vitro
- Ensaio baseado em fluorescência para a identificação de inibidores da protease nsP2 do vírus Chikungunya (CHIKV)
- Identificação de inibidores da protease do vírus Zika através da triagem da biblioteca Hit Generation Library (HGL1) do Medicines for Malaria Venture (MMV)
- Clonagem, expressão e purificação da protease (nsP2pro) do vírus Chikungunya
Informações sobre o DOI: 10.1038/s41467-025-63602-z (Fonte: oaDOI API)
Download do texto completo
| Tipo | Nome | Link | |
|---|---|---|---|
 |
3272334.pdf | Direct link |
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
