Azide-functionalization of melanin free pullulan for further use in click chemistry. (2018)
- Authors:
- USP affiliated authors: SANTOS, AMILTON MARTINS DOS - EEL ; SAMPAIO, SIMONE DE FÁTIMA MEDEIROS - EEL ; HILARES, RULY TERÁN - EEL ; SALIM, CLÁUDIA SANTOS - EEL ; MORAES, RODOLFO MINTO DE - EEL ; CARVALHO, LAYDE TEIXEIRA DE - EEL
- Unidade: EEL
- Sigla do Departamento: LOQ
- Assunto: POLÍMEROS (MATERIAIS)
- Language: Inglês
- Abstract: Pullulan is a hydrophilic polysaccharide, with low toxicity, great biodegradability and biocompatibility, possible to be used in drug/gene delivery systems [1]. In order to produce a polysaccharide with specific properties, different chemical modifications may be done in pullulan, among then there are the chemical reactions of etherification, oxidation, nucleophilic displacement and grafting [2]. This paper describes the preparation of the melanin free pullulan modified with azides groups in the polymer backbone. The product of the modification will be used in further “click chemistry” reactions to graft polymerization with alkyneend group hydrophobic homopolymers in order to produce amphiphilic structures. Thereafter, the resulted copolymers will be applied on drug delivery system due to its aggregation capability in aqueous solutions. To obtain the azide functionalized pullulan, a compound with azide group and brome, 2-azidoethyl 2- bromopropanoate, was synthetized in two steps: firstly, the intermediated 2- azidoethanol (AE) was obtained by reacting 2-bromoethanol with sodium azide and then it was reacted with 2-bromopriprionyl bromide, in the presence of triethylamine to produce AEBP. At last, the compound synthetized were used in the pullulan functionalization, in the presence of potassium carbonate. Part of the hydroxyl groups from pullulan were reacted with the halide from the AEBP. The chemical structure of the AE, AEBP and modified pullulan were confirmed by 1H NMR and FTIR. Besides that, the complementary techniques of contact angle, UV/Vis and CHN elemental analysis were also used to confirm the modification on pullulan structure.
- Imprenta:
- Source:
- Título: XVII Brazilian MRS Meeting
- Volume/Número/Paginação/Ano: p. 520
-
ABNT
CARVALHO, Layde T. et al. Azide-functionalization of melanin free pullulan for further use in click chemistry. 2018, Anais.. Natal-RN: ASPMat, 2018. p. 520. Disponível em: file:///C:/Users/Evelyze/Desktop/xviisbpmat/proceedings/pdfs/plenary/4DXK.pdf. Acesso em: 28 dez. 2025. -
APA
Carvalho, L. T., Moraes, R. M. de, Hilares, R. T., Salim, C. S., Santos, A. M. dos, & Medeiros, S. de F. (2018). Azide-functionalization of melanin free pullulan for further use in click chemistry. In XVII Brazilian MRS Meeting (p. 520). Natal-RN: ASPMat. Recuperado de file:///C:/Users/Evelyze/Desktop/xviisbpmat/proceedings/pdfs/plenary/4DXK.pdf -
NLM
Carvalho LT, Moraes RM de, Hilares RT, Salim CS, Santos AM dos, Medeiros S de F. Azide-functionalization of melanin free pullulan for further use in click chemistry. [Internet]. XVII Brazilian MRS Meeting. 2018 ; 520.[citado 2025 dez. 28 ] Available from: file:///C:/Users/Evelyze/Desktop/xviisbpmat/proceedings/pdfs/plenary/4DXK.pdf -
Vancouver
Carvalho LT, Moraes RM de, Hilares RT, Salim CS, Santos AM dos, Medeiros S de F. Azide-functionalization of melanin free pullulan for further use in click chemistry. [Internet]. XVII Brazilian MRS Meeting. 2018 ; 520.[citado 2025 dez. 28 ] Available from: file:///C:/Users/Evelyze/Desktop/xviisbpmat/proceedings/pdfs/plenary/4DXK.pdf - Modificação química da pululana para aplicação em sistemas de liberação controlada de princípios ativos.
- Síntese do copolímero anfifílico enxertado pululana-g-poli(ε-caprolactona), via "click chemistry".
- Síntese e caracterização da poli(N-vinilcaprolactama) contendo grupos hidroxila, e sua posterior funcionalização com grupo azida: SÍNTESE E CARACTERIZAÇÃO DA POLI(N-VINILCAPROLACTAMA) CONTENDO GRUPO HIDROXILA, E SUA POSTERIOR FUNCIONALIZAÇÃO COM GRUPO AZIDA
- Obtenção de poliésteres biocompatíveis e biodegradáveis funcionalizados com grupo terminal alcino para reações posteriores de enxertia.
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- Synthesis of amphiphilic poly(ε-caprolactone)-b-poly(N-vinylcaprolactam) block copolymers via the combination of Ring-Opening and RAFT copolymerizations and Click Chemistry
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- Synthesis of amphiphilic poly(ε-caprolactone)-b-poly(N-isopropylacrylamide) block copolymers via the Combination of Ring-Opening and RAFT Polymerizations
- Synthesis of amphiphilic pullulan-graft-poly(ε-caprolactone) via click chemistry
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