Artigo de periodico

Hit-to-lead studies of pyrazinylpiperazines against visceral Leishmaniasis: pharmacokinetic profile and in vivo efficacy of potent compounds against Leishmania infantum (2025)

• Authors:
  • Lapierre, Thibault Joseph William Jacques Dit
  • Cruz, Mariza Gabriela Faleiro de Moura Lodi
  • Barbosa, Gisele
  • Costa, Analu Rocha
  • Chávez-Fumagalli, Miguel Angel
  • Froes, Thamires Quadros
  • Ramos, Priscila Zonzini
  • Macruz, Paula Derksen
  • Trindade, Thalita Carolyne Souza
  • Pilau, Eduardo Jorge
  • Veras, Patricia Sampaio Tavares
  • Nonato, Maria Cristina
  • Massirer, Katlin Brauer
  • Ferreira, Leonardo Luiz Gomes
  • Andricopulo, Adriano Defini
  • Lima, Lídia Moreira
  • Murta, Silvane M. F.
  • Rezende Junior, Celso de Oliveira
• USP affiliated authors: NONATO, MARIA CRISTINA - FCFRP ; FERREIRA, LEONARDO LUIZ GOMES - IFSC ; ANDRICOPULO, ADRIANO DEFINI - IFSC ; COSTA, ANALU ROCHA - IFSC ; FROES, THAMIRES QUADROS - FCFRP
• Unidades: FCFRP; IFSC
• DOI: 10.1021/acsptsci.5c00318
• Subjects: LEISHMANIA; CRISTALOGRAFIA; FÁRMACOS
• Keywords: Pyrazinylpiperazines; Visceral Leishmaniasis; Lead discovery; Pharmacokinetics; Mechanism of action
• Agências de fomento:
  • Financiamento FAPEMIG
  • Financiamento CNPq
  • Financiamento FAPESP
• Language: Inglês
• Imprenta:
  • Publisher place: Washington, DC
  • Date published: 2025
• Source:
  • Título: ACS Pharmacology and Translational Science
  • ISSN: 2575-9108
  • Volume/Número/Paginação/Ano: v. 8, n. 8, p. 2736–2755 + supporting information, Aug. 2025


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• ABNT

  LAPIERRE, Thibault Joseph William Jacques Dit et al. Hit-to-lead studies of pyrazinylpiperazines against visceral Leishmaniasis: pharmacokinetic profile and in vivo efficacy of potent compounds against Leishmania infantum. ACS Pharmacology and Translational Science, v. 8, n. 8, p. 2736–2755 + supporting information, 2025Tradução . . Disponível em: https://doi.org/10.1021/acsptsci.5c00318. Acesso em: 14 abr. 2026.

• APA

  Lapierre, T. J. W. J. D., Cruz, M. G. F. de M. L., Barbosa, G., Costa, A. R., Chávez-Fumagalli, M. A., Froes, T. Q., et al. (2025). Hit-to-lead studies of pyrazinylpiperazines against visceral Leishmaniasis: pharmacokinetic profile and in vivo efficacy of potent compounds against Leishmania infantum. ACS Pharmacology and Translational Science, 8( 8), 2736–2755 + supporting information. doi:10.1021/acsptsci.5c00318

• NLM

  Lapierre TJWJD, Cruz MGF de ML, Barbosa G, Costa AR, Chávez-Fumagalli MA, Froes TQ, Ramos PZ, Macruz PD, Trindade TCS, Pilau EJ, Veras PST, Nonato MC, Massirer KB, Ferreira LLG, Andricopulo AD, Lima LM, Murta SMF, Rezende Junior C de O. Hit-to-lead studies of pyrazinylpiperazines against visceral Leishmaniasis: pharmacokinetic profile and in vivo efficacy of potent compounds against Leishmania infantum [Internet]. ACS Pharmacology and Translational Science. 2025 ; 8( 8): 2736–2755 + supporting information.[citado 2026 abr. 14 ] Available from: https://doi.org/10.1021/acsptsci.5c00318

• Vancouver

  Lapierre TJWJD, Cruz MGF de ML, Barbosa G, Costa AR, Chávez-Fumagalli MA, Froes TQ, Ramos PZ, Macruz PD, Trindade TCS, Pilau EJ, Veras PST, Nonato MC, Massirer KB, Ferreira LLG, Andricopulo AD, Lima LM, Murta SMF, Rezende Junior C de O. Hit-to-lead studies of pyrazinylpiperazines against visceral Leishmaniasis: pharmacokinetic profile and in vivo efficacy of potent compounds against Leishmania infantum [Internet]. ACS Pharmacology and Translational Science. 2025 ; 8( 8): 2736–2755 + supporting information.[citado 2026 abr. 14 ] Available from: https://doi.org/10.1021/acsptsci.5c00318

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