Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine (2021)
- Authors:
- Reis, Thaila Fernanda dos

- Horta, Maria Augusta Crivelente
- Colabardini, Ana Cristina
- Fernandes, Caroline Mota
- Silva, Lilian Pereira

- Bastos, Rafael Wesley

- Fonseca, Maria Vitória de Lazari
- Wang, Fang
- Martins, Celso
- Rodrigues, Márcio L
- Pereira, Cristina Silva
- Del Poeta, Maurizio
- Wong, Koon Ho
- Goldman, Gustavo Henrique

- Reis, Thaila Fernanda dos
- USP affiliated authors: REIS, THAILA FERNANDA DOS - FMRP ; BASTOS, RAFAEL WESLEY - FCFRP ; GOLDMAN, GUSTAVO HENRIQUE - FCFRP ; FONSECA, MARIA VITÓRIA DE LAZARI - FCFRP ; SILVA, LILIAN PEREIRA - FMRP
- Unidades: FMRP; FCFRP
- DOI: 10.1128/mBio.01458-21
- Subjects: ANTIFÚNGICOS; ASPERGILLUS; FARMACOTERAPIA; LARVA; TESTES DE SENSIBILIDADE MICROBIANA; VIRULÊNCIA
- Keywords: Aspergillus fumigatus; Drug repurposing; Miltefosine; Sphingolipids; Transcription factor
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher place: Washington
- Date published: 2021
- Source:
- Este periódico é de acesso aberto
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: green
- Licença: other-oa
-
ABNT
REIS, Thaila Fernanda dos et al. Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine. mBio, v. 12, n. 4, 2021Tradução . . Disponível em: https://doi.org/10.1128/mBio.01458-21. Acesso em: 27 dez. 2025. -
APA
Reis, T. F. dos, Horta, M. A. C., Colabardini, A. C., Fernandes, C. M., Silva, L. P., Bastos, R. W., et al. (2021). Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine. mBio, 12( 4). doi:10.1128/mBio.01458-21 -
NLM
Reis TF dos, Horta MAC, Colabardini AC, Fernandes CM, Silva LP, Bastos RW, Fonseca MV de L, Wang F, Martins C, Rodrigues ML, Pereira CS, Del Poeta M, Wong KH, Goldman GH. Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine [Internet]. mBio. 2021 ; 12( 4):[citado 2025 dez. 27 ] Available from: https://doi.org/10.1128/mBio.01458-21 -
Vancouver
Reis TF dos, Horta MAC, Colabardini AC, Fernandes CM, Silva LP, Bastos RW, Fonseca MV de L, Wang F, Martins C, Rodrigues ML, Pereira CS, Del Poeta M, Wong KH, Goldman GH. Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine [Internet]. mBio. 2021 ; 12( 4):[citado 2025 dez. 27 ] Available from: https://doi.org/10.1128/mBio.01458-21 - The Aspergillus fumigatus Mismatch repair MSH2 homolog is important for virulence and azole resistance
- Inadvertent selection of a pathogenic fungus highlights areas of concern in human clinical practices
- Fungicide effects on human fungal pathogens: cross-resistance to medical drugs and beyond
- GPCR-mediated glucose sensing system regulates light-dependent fungal development and mycotoxin production
- Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution
- Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin
- Gliotoxin, a known virulence factor in the major human pathogen Aspergillus fumigatus, is also biosynthesized by its nonpathogenic relative Aspergillus fischeri
- Genetic interactions between aspergillus fumigatus basic leucine zipper (bZIP) transcription factors AtfA, AtfB, AtfC, and AtfD
- Genomic and phenotypic heterogeneity of clinical isolates of the human pathogens Aspergillus fumigatus, Aspergillus lentulus, and Aspergillus fumigatiaffinis
- Carbon catabolite repression in filamentous fungi is regulated by phosphorylation of the transcription factor CreA
Informações sobre o DOI: 10.1128/mBio.01458-21 (Fonte: oaDOI API)
Download do texto completo
| Tipo | Nome | Link | |
|---|---|---|---|
| 003239789.pdf | Direct link |
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas