Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine (2021)
- Authors:
- Reis, Thaila Fernanda dos
- Horta, Maria Augusta Crivelente
- Colabardini, Ana Cristina
- Fernandes, Caroline Mota
- Silva, Lilian Pereira
- Bastos, Rafael Wesley
- Fonseca, Maria Vitória de Lazari
- Wang, Fang
- Martins, Celso
- Rodrigues, Márcio L
- Pereira, Cristina Silva
- Del Poeta, Maurizio
- Wong, Koon Ho
- Goldman, Gustavo Henrique
- Reis, Thaila Fernanda dos
- USP affiliated authors: REIS, THAILA FERNANDA DOS - FMRP ; BASTOS, RAFAEL WESLEY - FCFRP ; GOLDMAN, GUSTAVO HENRIQUE - FCFRP ; FONSECA, MARIA VITÓRIA DE LAZARI - FCFRP ; SILVA, LILIAN PEREIRA - FMRP
- Unidades: FMRP; FCFRP
- DOI: 10.1128/mBio.01458-21
- Subjects: ANTIFÚNGICOS; ASPERGILLUS; FARMACOTERAPIA; LARVA; TESTES DE SENSIBILIDADE MICROBIANA; VIRULÊNCIA
- Keywords: Aspergillus fumigatus; Drug repurposing; Miltefosine; Sphingolipids; Transcription factor
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher place: Washington
- Date published: 2021
- Source:
- Status:
- Artigo publicado em periódico de acesso aberto (Gold Open Access)
- Versão do Documento:
- Versão publicada (Published version)
- Acessar versão aberta:
-
ABNT
REIS, Thaila Fernanda dos et al. Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine. mBio, v. 12, n. 4, 2021Tradução . . Disponível em: https://doi.org/10.1128/mBio.01458-21. Acesso em: 29 mar. 2026. -
APA
Reis, T. F. dos, Horta, M. A. C., Colabardini, A. C., Fernandes, C. M., Silva, L. P., Bastos, R. W., et al. (2021). Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine. mBio, 12( 4). doi:10.1128/mBio.01458-21 -
NLM
Reis TF dos, Horta MAC, Colabardini AC, Fernandes CM, Silva LP, Bastos RW, Fonseca MV de L, Wang F, Martins C, Rodrigues ML, Pereira CS, Del Poeta M, Wong KH, Goldman GH. Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine [Internet]. mBio. 2021 ; 12( 4):[citado 2026 mar. 29 ] Available from: https://doi.org/10.1128/mBio.01458-21 -
Vancouver
Reis TF dos, Horta MAC, Colabardini AC, Fernandes CM, Silva LP, Bastos RW, Fonseca MV de L, Wang F, Martins C, Rodrigues ML, Pereira CS, Del Poeta M, Wong KH, Goldman GH. Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine [Internet]. mBio. 2021 ; 12( 4):[citado 2026 mar. 29 ] Available from: https://doi.org/10.1128/mBio.01458-21 - The Aspergillus fumigatus Mismatch repair MSH2 homolog is important for virulence and azole resistance
- Inadvertent selection of a pathogenic fungus highlights areas of concern in human clinical practices
- Fungicide effects on human fungal pathogens: cross-resistance to medical drugs and beyond
- Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution
- GPCR-mediated glucose sensing system regulates light-dependent fungal development and mycotoxin production
- Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin
- Genetic interactions between aspergillus fumigatus basic leucine zipper (bZIP) transcription factors AtfA, AtfB, AtfC, and AtfD
- Carbon catabolite repression in filamentous fungi is regulated by phosphorylation of the transcription factor CreA
- Genomic and phenotypic heterogeneity of clinical isolates of the human pathogens Aspergillus fumigatus, Aspergillus lentulus, and Aspergillus fumigatiaffinis
- Transcriptional control of the production of Aspergillus fumigatus conidia-borne secondary metabolite fumiquinazoline C important for phagocytosis protection
Informações sobre a disponibilidade de versões do artigo em acesso aberto coletadas automaticamente via oaDOI API (Unpaywall).
Por se tratar de integração com serviço externo, podem existir diferentes versões do trabalho (como preprints ou postprints), que podem diferir da versão publicada.
Download do texto completo
| Tipo | Nome | Link | |
|---|---|---|---|
 |
003239789.pdf | Direct link |
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
