In vitro metabolism and cytotoxicity of parthenolide: the complete identification of the major oxidative product and the evaluation of trypanocidal and leishmanicidal activities (2025)
- Authors:
- USP affiliated authors: OLIVEIRA, ANDERSON RODRIGO MORAES DE - FFCLRP ; LOPES, NORBERTO PEPORINE - FCFRP
- Unidades: FFCLRP; FCFRP
- DOI: 10.21577/0103-5053.20240082
- Subjects: PLANTAS MEDICINAIS; OXIDAÇÃO; FLAVONOIDES; CITOTOXICIDADE IMUNOLÓGICA
- Keywords: Parthenolide, (1R,10R)-epoxyparthenolide; Biomimetic oxidation; Liver microsomal metabolism; Trypanocidal; Leishmanicidal
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: Journal of the Brazilian Chemical Society
- ISSN: 0103-5053
- Volume/Número/Paginação/Ano: v. 36, n. 1, art. e-20240082, p. 1-8, 2025
- Status:
- Artigo publicado em periódico de acesso aberto (Gold Open Access)
- Versão do Documento:
- Versão publicada (Published version)
- Acessar versão aberta:
-
ABNT
SILVÉRIO, Maíra Rosato Silveira et al. In vitro metabolism and cytotoxicity of parthenolide: the complete identification of the major oxidative product and the evaluation of trypanocidal and leishmanicidal activities. Journal of the Brazilian Chemical Society, v. 36, n. 1, p. 1-8, 2025Tradução . . Disponível em: https://doi.org/10.21577/0103-5053.20240082. Acesso em: 30 mar. 2026. -
APA
Silvério, M. R. S., Callejon, D. R., Batista Junior, J. M., Riul, T. B., Oliveira, A. R. M. de, & Lopes, N. P. (2025). In vitro metabolism and cytotoxicity of parthenolide: the complete identification of the major oxidative product and the evaluation of trypanocidal and leishmanicidal activities. Journal of the Brazilian Chemical Society, 36( 1), 1-8. doi:10.21577/0103-5053.20240082 -
NLM
Silvério MRS, Callejon DR, Batista Junior JM, Riul TB, Oliveira ARM de, Lopes NP. In vitro metabolism and cytotoxicity of parthenolide: the complete identification of the major oxidative product and the evaluation of trypanocidal and leishmanicidal activities [Internet]. Journal of the Brazilian Chemical Society. 2025 ; 36( 1): 1-8.[citado 2026 mar. 30 ] Available from: https://doi.org/10.21577/0103-5053.20240082 -
Vancouver
Silvério MRS, Callejon DR, Batista Junior JM, Riul TB, Oliveira ARM de, Lopes NP. In vitro metabolism and cytotoxicity of parthenolide: the complete identification of the major oxidative product and the evaluation of trypanocidal and leishmanicidal activities [Internet]. Journal of the Brazilian Chemical Society. 2025 ; 36( 1): 1-8.[citado 2026 mar. 30 ] Available from: https://doi.org/10.21577/0103-5053.20240082 - In vitro inhibition of human CYP450s 1A2, 2C9, 3A4/5, 2D6 and 2E1 by grandisin
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