In vitro metabolism and cytotoxicity of parthenolide: the complete identification of the major oxidative product and the evaluation of trypanocidal and leishmanicidal activities (2025)
- Authors:
- USP affiliated authors: OLIVEIRA, ANDERSON RODRIGO MORAES DE - FFCLRP ; LOPES, NORBERTO PEPORINE - FCFRP
- Unidades: FFCLRP; FCFRP
- DOI: 10.21577/0103-5053.20240082
- Subjects: PLANTAS MEDICINAIS; OXIDAÇÃO; FLAVONOIDES; CITOTOXICIDADE IMUNOLÓGICA
- Keywords: Parthenolide, (1R,10R)-epoxyparthenolide; Biomimetic oxidation; Liver microsomal metabolism; Trypanocidal; Leishmanicidal
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: Journal of the Brazilian Chemical Society
- ISSN: 0103-5053
- Volume/Número/Paginação/Ano: v. 36, n. 1, art. e-20240082, p. 1-8, 2025
- Este periódico é de acesso aberto
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: gold
- Licença: cc-by
-
ABNT
SILVÉRIO, Maíra Rosato Silveira et al. In vitro metabolism and cytotoxicity of parthenolide: the complete identification of the major oxidative product and the evaluation of trypanocidal and leishmanicidal activities. Journal of the Brazilian Chemical Society, v. 36, n. 1, p. 1-8, 2025Tradução . . Disponível em: https://doi.org/10.21577/0103-5053.20240082. Acesso em: 27 dez. 2025. -
APA
Silvério, M. R. S., Callejon, D. R., Batista Junior, J. M., Riul, T. B., Oliveira, A. R. M. de, & Lopes, N. P. (2025). In vitro metabolism and cytotoxicity of parthenolide: the complete identification of the major oxidative product and the evaluation of trypanocidal and leishmanicidal activities. Journal of the Brazilian Chemical Society, 36( 1), 1-8. doi:10.21577/0103-5053.20240082 -
NLM
Silvério MRS, Callejon DR, Batista Junior JM, Riul TB, Oliveira ARM de, Lopes NP. In vitro metabolism and cytotoxicity of parthenolide: the complete identification of the major oxidative product and the evaluation of trypanocidal and leishmanicidal activities [Internet]. Journal of the Brazilian Chemical Society. 2025 ; 36( 1): 1-8.[citado 2025 dez. 27 ] Available from: https://doi.org/10.21577/0103-5053.20240082 -
Vancouver
Silvério MRS, Callejon DR, Batista Junior JM, Riul TB, Oliveira ARM de, Lopes NP. In vitro metabolism and cytotoxicity of parthenolide: the complete identification of the major oxidative product and the evaluation of trypanocidal and leishmanicidal activities [Internet]. Journal of the Brazilian Chemical Society. 2025 ; 36( 1): 1-8.[citado 2025 dez. 27 ] Available from: https://doi.org/10.21577/0103-5053.20240082 - Analytical tools the enantioselective analysis of drugs and metabolites
- In vitro metabolism studies of natural products are crucial in the early development of medicines
- In vitro inhibition of human CYP450s 1A2, 2C9, 3A4/5, 2D6 and 2E1 by grandisin
- In vitro metabolism of the lignan (-)-grandisin, an anticancer drug candidate, by human liver microsomes
- Biomimetic metabolism of Kaurenoic acid validated by microsomal reactions
- A non-michaelian behavior of the in vitro metabolism of the pentacyclic triterpene alfa and beta amyrins by employing rat liver microsomes
- Validation of an HPLC-UV method for in vitro metabolism studies of Casearin X
- Microsomal metabolism of erythraline: an anxiolitic spiroalkaloid
- Metabolic profile and safety of piperlongumine
- Evaluation of the intestinal absorption mechanism of casearin X in caco-2 cells with modified carboxylesterase activity
Informações sobre o DOI: 10.21577/0103-5053.20240082 (Fonte: oaDOI API)
Download do texto completo
| Tipo | Nome | Link | |
|---|---|---|---|
 |
003232726.pdf | Direct link |
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas
