Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo (2023)
- Authors:
- Silvestre, Renata Nacasaki

- Eitler, Jiri
- Azevedo, Júlia Teixeira Cottas de

- Tirapelle, Mariane Cariati
- Fantacini, Daianne Maciely Carvalho

- Souza, Lucas Eduardo Botelho de

- Swiech, Kamilla

- Covas, Dimas Tadeu

- Calado, Rodrigo Tocantins

- Montero, Paola Ortiz
- Malmegrim, Kelen Cristina Ribeiro

- Figueiredo, Marxa L.
- Tonn, Torsten
- Picanço-Castro, Virgínia

- Silvestre, Renata Nacasaki
- USP affiliated authors: SOUZA, LUCAS EDUARDO BOTELHO DE - FMRP ; ANTONIETTO, KAMILLA SWIECH - FCFRP ; COVAS, DIMAS TADEU - FMRP ; RODRIGUES, RODRIGO DO TOCANTINS CALADO DE SALOMA - FMRP ; CASTRO, VIRGÍNIA PICANÇO E - FMRP ; TIRAPELLE, MARIANE CARIATI - FMRP
- Unidades: FMRP; FCFRP
- DOI: 10.3389/fimmu.2023.1226518
- Subjects: ANTÍGENOS; LINHAGEM CELULAR; PROLIFERAÇÃO CELULAR; INTERLEUCINAS
- Keywords: B-cell malignances; CAR-NK cells; IL-15; IL-15 receptor; NK-92; Adoptive cell therapy; Allogeneic therapy
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: Frontiers in Immunology
- ISSN: 1664-3224
- Volume/Número/Paginação/Ano: v. 14, art. 1226518, p. 1-15, 2023
- Status:
- Artigo publicado em periódico de acesso aberto (Gold Open Access)
- Versão do Documento:
- Versão publicada (Published version)
- Acessar versão aberta:
-
ABNT
SILVESTRE, Renata Nacasaki et al. Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo. Frontiers in Immunology, v. 14, p. 1-15, 2023Tradução . . Disponível em: https://doi.org/10.3389/fimmu.2023.1226518. Acesso em: 02 abr. 2026. -
APA
Silvestre, R. N., Eitler, J., Azevedo, J. T. C. de, Tirapelle, M. C., Fantacini, D. M. C., Souza, L. E. B. de, et al. (2023). Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo. Frontiers in Immunology, 14, 1-15. doi:10.3389/fimmu.2023.1226518 -
NLM
Silvestre RN, Eitler J, Azevedo JTC de, Tirapelle MC, Fantacini DMC, Souza LEB de, Swiech K, Covas DT, Calado RT, Montero PO, Malmegrim KCR, Figueiredo ML, Tonn T, Picanço-Castro V. Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo [Internet]. Frontiers in Immunology. 2023 ; 14 1-15.[citado 2026 abr. 02 ] Available from: https://doi.org/10.3389/fimmu.2023.1226518 -
Vancouver
Silvestre RN, Eitler J, Azevedo JTC de, Tirapelle MC, Fantacini DMC, Souza LEB de, Swiech K, Covas DT, Calado RT, Montero PO, Malmegrim KCR, Figueiredo ML, Tonn T, Picanço-Castro V. Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo [Internet]. Frontiers in Immunology. 2023 ; 14 1-15.[citado 2026 abr. 02 ] Available from: https://doi.org/10.3389/fimmu.2023.1226518 - Successful use of human AB serum to support the expansion of adipose tissue-derived mesenchymal stem/stromal cell in a microcarrier-based platform
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- A Fully-closed and automated hollow fiber bioreactor for clinical-grade manufacturing of human Mesenchymal stem/stromal cells
- Production of coagulation factor VII in human cell lines Sk-Hep-1 and HKB-11
- Feasibility of the taylor vortex flow bioreactor for mesenchymal stromal cell expansion on microcarriers
- Mesenchymal stromal cells maintain the major quality attributes when expanded in different bioreactor systems
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