Combined vancomycin-meropenem therapy in pediatric major burns undergoing therapy of septic shock guided by cultures and pharmacokinetic-pharmacodynamics approach based on serum levels to combat bacterial resistance (2023)
- Authors:
- Santos, Silvia Regina Cavani Jorge

- Camargo, Thais Vieira de

- Messiano, Claudia Garcia

- Kupa, Leonard de Vinci Kanda

- Morales Júnior, Ronaldo

- Souza, Vanessa Kasubeck de

- Pires, Frederico Ribeiro
- Pinto, Débora Cristina Sanches

- Campos, Edvaldo Vieira de

- Silva Junior, Elson Mendes da

- Silva Junior, João Manoel da

- Santos, Silvia Regina Cavani Jorge
- USP affiliated authors: SANTOS, SILVIA REGINA CAVANI JORGE - FCF ; SILVA JUNIOR, JOÃO MANOEL DA - FM ; KUPA, LEONARD DE VINCI KANDA - FM ; PINTO, DÉBORA CRISTINA SANCHES - FM ; SILVA JÚNIOR, ELSON MENDES DA - FM
- Unidades: FCF; FM
- DOI: 10.15406/ppij.2023.11.00403
- Subjects: CHOQUE SÉPTICO; QUEIMADURAS
- Language: Inglês
- Imprenta:
- Source:
- Título: Pharmacy and Pharmacology International Journal
- ISSN: 2379-6367
- Volume/Número/Paginação/Ano: v. 11,n. 2, p. 62‒68, 2023
- Status:
- Artigo possui acesso gratuito no site do editor (Bronze Open Access)
- Versão do Documento:
- Versão publicada (Published version)
- Acessar versão aberta:
-
ABNT
SANTOS, Silvia Regina Cavani Jorge et al. Combined vancomycin-meropenem therapy in pediatric major burns undergoing therapy of septic shock guided by cultures and pharmacokinetic-pharmacodynamics approach based on serum levels to combat bacterial resistance. Pharmacy and Pharmacology International Journal, v. 11, n. 2, p. 62‒68, 2023Tradução . . Disponível em: https://dx.doi.org/10.15406/ppij.2023.11.00403. Acesso em: 16 abr. 2026. -
APA
Santos, S. R. C. J., Camargo, T. V. de, Messiano, C. G., Kupa, L. de V. K., Morales Júnior, R., Souza, V. K. de, et al. (2023). Combined vancomycin-meropenem therapy in pediatric major burns undergoing therapy of septic shock guided by cultures and pharmacokinetic-pharmacodynamics approach based on serum levels to combat bacterial resistance. Pharmacy and Pharmacology International Journal, 11( 2), 62‒68. doi:10.15406/ppij.2023.11.00403 -
NLM
Santos SRCJ, Camargo TV de, Messiano CG, Kupa L de VK, Morales Júnior R, Souza VK de, Pires FR, Pinto DCS, Campos EV de, Silva Junior EM da, Silva Junior JM da. Combined vancomycin-meropenem therapy in pediatric major burns undergoing therapy of septic shock guided by cultures and pharmacokinetic-pharmacodynamics approach based on serum levels to combat bacterial resistance [Internet]. Pharmacy and Pharmacology International Journal. 2023 ; 11( 2): 62‒68.[citado 2026 abr. 16 ] Available from: https://dx.doi.org/10.15406/ppij.2023.11.00403 -
Vancouver
Santos SRCJ, Camargo TV de, Messiano CG, Kupa L de VK, Morales Júnior R, Souza VK de, Pires FR, Pinto DCS, Campos EV de, Silva Junior EM da, Silva Junior JM da. Combined vancomycin-meropenem therapy in pediatric major burns undergoing therapy of septic shock guided by cultures and pharmacokinetic-pharmacodynamics approach based on serum levels to combat bacterial resistance [Internet]. Pharmacy and Pharmacology International Journal. 2023 ; 11( 2): 62‒68.[citado 2026 abr. 16 ] Available from: https://dx.doi.org/10.15406/ppij.2023.11.00403 - Combating bacterial resistance to antimicrobials in severe septic ICU patients: importance of meropenem, piperacillin serum monitoring as a dose adjustment and duration of infusion strategies
- Bioanalytical methods based on liquid chromatography for the therapeutic drug monitoring of combined therapies of antibiotics in pediatric septic major burns
- Antimicrobial therapy in severe septic ICU major burn patients to combat bacterial resistance by pharmacokinetic-pharmacodymamics of vancomycin, meropenem, and piperacillin, cultures, and inflammatory biomarkers
- Vancomycin dose adjustment in critically ill burn patients using the pharmacokinetic/pharmacodynamic approach against Gram-positive MIC 2 mg/l strains
- Beta-lactam agents serum measurements by liquid chromatography to evaluate meropenem and piperacillin effectiveness in septic burn adults with a pharmacokinetic-pharmacodynamic approach
- Meropenem extended infusion to guarantee drug effectiveness against nosocomial MIC 4 mg/l strains in burn patients at the earlier period of septic shock
- The pharmacokinetic/pharmacodynamic approach in pediatric septic burn patients to guarantee vancomycin effectiveness against Staphylococcus
- Therapeutic target attainment of 3-Hour extended Infusion of Meropenem in patients with septic burns
- Combating bacterial resistance to Meropenem by infusion strategy applied to septic burn patients with vasopressor requirements or acute kidney injury to achieve the target
- Extended two-hour infusion improves piperacillin effectiveness against susceptible strains in septic burn patients
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