Artigo de periodico

Toxicological effects caused by environmental relevant concentrations of ketoconazole in Chironomus sancticaroli (Diptera, Chironomidae) larvae evaluated by oxidative stress biomarkers (2023)

• Authors:
  • Prado, Caio César Achiles do
  • Queiroz, Lucas Gonçalves
  • Silva, Flávio Teixeira
  • Paiva, Teresa Cristina Brazil de
• USP affiliated authors: SILVA, FLÁVIO TEIXEIRA DA - EEL ; PAIVA, TERESA CRISTINA BRAZIL DE - EEL ; PRADO, CAIO CÉSAR ACHILES DO - EEL ; QUEIROZ, LUCAS GONÇALVES - IQ
• Unidades: EEL; IQ
• DOI: 10.1016/j.cbpc.2022.109532
• Subjects: BIOTECNOLOGIA; ECOTOXICOLOGIA
• Keywords: Micropollutants; Drugs; Imidazole; Ecotoxicology; Chironomus sp.
• Agências de fomento:
  • Financiamento CAPES
• Language: Inglês
• Abstract: Ketoconazole (KTZ), a broad-spectrum fungicidal drug, has been a significant problem in recent decades due to its toxic action on non-target aquatic organisms. Thus, the present study aimed to evaluate determine the effects that environmental relevant concentration of the commercial formulation of KTZ can exert on benthic macroinvertebrates, more specifically on larvae of the insect Chironomus sancticaroli. Acute toxicity tests with KTZ indicated lethal concentration (LC50) of 9.9 μg/L. Analyses of prolonged exposure to KTZ (chronic toxicity) indicated an increase in the rate of mentum deformity by approximately 3 times at concentrations of 0.6 and 2.4 μg/L. All biomarkers analyzed showed an increase after exposure to KTZ (0.6 and 2.4 μg/L), with average values of 115 % for superoxide dismutase (SOD), 63 % for catalase (CAT), 111 % for glutathione S-transferase (GST) and 59 % for malonaldehyde (MDA) in C. sancticaroli larvae. Thus, the toxic effects on survival, development (length and weight), mentum and redox responses caused by commercial KTZ in low concentrations were observed on C. sancticaroli larvae. In addition, the results suggest that biochemical biomarkers can be used for studies involving environmental disturbances.
• Imprenta:
  • Publisher: Elsevier
  • Publisher place: Miami - Fl
  • Date published: 2023
• Source:
  • Título: Comparative biochemistry and physiology c-toxicology & pharmacology
  • ISSN: 1532-0456
  • Volume/Número/Paginação/Ano: v.264, p.1-8, art. 109532, 2023

Informações sobre o DOI: 10.1016/j.cbpc.2022.109532 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo é de acesso aberto
• URL de acesso aberto
• Cor do Acesso Aberto: bronze
• Licença: publisher-specific-oa

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How to cite

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• ABNT

  PRADO, Caio César Achiles do et al. Toxicological effects caused by environmental relevant concentrations of ketoconazole in Chironomus sancticaroli (Diptera, Chironomidae) larvae evaluated by oxidative stress biomarkers. Comparative biochemistry and physiology c-toxicology & pharmacology, v. 264, p. 1-8, 2023Tradução . . Disponível em: https://doi.org/10.1016/j.cbpc.2022.109532. Acesso em: 28 dez. 2025.

• APA

  Prado, C. C. A. do, Queiroz, L. G., Silva, F. T., & Paiva, T. C. B. de. (2023). Toxicological effects caused by environmental relevant concentrations of ketoconazole in Chironomus sancticaroli (Diptera, Chironomidae) larvae evaluated by oxidative stress biomarkers. Comparative biochemistry and physiology c-toxicology & pharmacology, 264, 1-8. doi:10.1016/j.cbpc.2022.109532

• NLM

  Prado CCA do, Queiroz LG, Silva FT, Paiva TCB de. Toxicological effects caused by environmental relevant concentrations of ketoconazole in Chironomus sancticaroli (Diptera, Chironomidae) larvae evaluated by oxidative stress biomarkers [Internet]. Comparative biochemistry and physiology c-toxicology & pharmacology. 2023 ;264 1-8.[citado 2025 dez. 28 ] Available from: https://doi.org/10.1016/j.cbpc.2022.109532

• Vancouver

  Prado CCA do, Queiroz LG, Silva FT, Paiva TCB de. Toxicological effects caused by environmental relevant concentrations of ketoconazole in Chironomus sancticaroli (Diptera, Chironomidae) larvae evaluated by oxidative stress biomarkers [Internet]. Comparative biochemistry and physiology c-toxicology & pharmacology. 2023 ;264 1-8.[citado 2025 dez. 28 ] Available from: https://doi.org/10.1016/j.cbpc.2022.109532

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