How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell (2023)
- Authors:
- USP affiliated authors: SILBER, ARIEL MARIANO - ICB ; NASCIMENTO, JANAINA DE FREITAS - ICB ; SOUZA, RODOLPHO ORNITZ OLIVEIRA - ICB ; ALENCAR, MAYKE BEZERRA - ICB ; DAMASCENO, FLÁVIA SILVA - ICB ; GIRARD, RICHARD MARCEL BRUNO MOREIRA - ICB ; MARCHESE, LETÍCIA - ICB ; ACHJIAN, RENAN WEEGE - ICB
- Unidade: ICB
- DOI: 10.1371/journal.ppat.1011522
- Subjects: PARASITOLOGIA; TRYPANOSOMA; ANIMAIS PARASITOS; BIOMASSA; CICLO CELULAR; POLIMERIZAÇÃO; GLICOSE; GLICOPROTEÍNAS
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher: Public Library of Science
- Publisher place: San Francisco, CA
- Date published: 2023
- Source:
- Título: PLoS Pathogens
- ISSN: 1553-7374
- Volume/Número/Paginação/Ano: v. 19, n. 7, p. 35, art. e1011522, 2023
- Status:
- Artigo publicado em periódico de acesso aberto (Gold Open Access)
- Versão do Documento:
- Versão publicada (Published version)
- Acessar versão aberta:
-
ABNT
NASCIMENTO, Janaina de Freitas et al. How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell. PLoS Pathogens, v. 19, n. 7, p. 35, 2023Tradução . . Disponível em: https://doi.org/10.1371/journal.ppat.1011522. Acesso em: 30 mar. 2026. -
APA
Nascimento, J. de F., Souza, R. O. O., Alencar, M. B., Marsiccobetre, S., Murillo, A. M., Damasceno, F., et al. (2023). How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell. PLoS Pathogens, 19( 7), 35. doi:10.1371/journal.ppat.1011522 -
NLM
Nascimento J de F, Souza ROO, Alencar MB, Marsiccobetre S, Murillo AM, Damasceno F, Girard RMBM, Marchese L, Luévano-Martinez LA, Achjian RW, Haanstra JR, Michels PAM, Silber AM. How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell [Internet]. PLoS Pathogens. 2023 ; 19( 7): 35.[citado 2026 mar. 30 ] Available from: https://doi.org/10.1371/journal.ppat.1011522 -
Vancouver
Nascimento J de F, Souza ROO, Alencar MB, Marsiccobetre S, Murillo AM, Damasceno F, Girard RMBM, Marchese L, Luévano-Martinez LA, Achjian RW, Haanstra JR, Michels PAM, Silber AM. How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell [Internet]. PLoS Pathogens. 2023 ; 19( 7): 35.[citado 2026 mar. 30 ] Available from: https://doi.org/10.1371/journal.ppat.1011522 - The branched chain amino acids (BCAAs) modulate the development of the intra-cellular stages of Trypanosoma cruzi
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- Trypanosoma cruzi synthesizes proline via a Δ1-pyrroline-5-carboxylate reductase whose activity is fine-tuned by NADPH cytosolic pools
- Branched-chain amino acids modulate the proteomic profile of Trypanosoma cruzi metacyclogenesis induced by proline
- Dichloroacetate and pyruvate metabolism: pyruvate dehydrogenase kinases as targets worth investigating for effective therapy of toxoplasmosis
- Knocking out histidine ammonia-lyase by using CRISPR-Cas9 abolishes histidine role in the bioenergetics and the life cycle of Trypanosoma cruzi
- ATP regulates the activity of an alternative oxidase in Trypanosoma brucei
- Correction for Girard et al., “Uptake of L-Alanine and Its Distinct Roles in the Bioenergetics of Trypanosoma cruzi”
- Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition–resistant triple-negative breast cancer cells
- An aromatic imidazoline derived from chloroquinoline triggers cell cycle arrest and inhibits with high selectivity the Trypanosoma cruzi mammalian host-cells infection
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