Artigo de periodico

Metronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing (2022)

• Authors:
  • Borges, Felipe Azevedo
  • Morais, Carla Pereira de
  • Marangoni, Bruno Spolon
  • Nicolodelli, Gustavo
  • Mecwan, Marvin
  • Mandal, Kalpana
  • Guerra, Nayrim Brizuela
  • Menegatti, Carlos Renato
  • Herculano, Rondinelli Donizetti
  • Drago, Bruno de Camargo
  • Baggio, Luís Otávio
  • Barros, Natan Roberto de
  • Brasil, Giovana Sant'Ana Pegorin
  • Scontri, Mateus
  • Mussagy, Cassamo Ussemane
  • Ribeiro, Matheus C. S
  • Milori, Debora Marcondes Bastos Pereira
• Autor USP: MENEGATTI, CARLOS RENATO - EEL
• Unidade: EEL
• DOI: 10.1016/j.ijbiomac.2022.05.025
• Assunto: NANOPARTÍCULAS
• Keywords: Gold nanoparticles; LIBS
• Agências de fomento:
  • Financiamento CAPES
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
    Processo FAPESP: 2011/17411-8,2012/12958-1,2014/17526-8,2017/19603-8,and2020/08655-0
  • Financiamento CNPq
• Language: Inglês
• Abstract: Gold nanoparticles (AuNPs) have shown interesting properties and specific biofunctions, providing benefits and new opportunities for controlled release systems. In this research, we demonstrated the use of natural rubber latex (NRL) from Hevea brasiliensis as a carrier of AuNPs and the antibiotic metronidazole (MET). We prepared AuNP-MET-NRL and characterized by physicochemical, biological and in vitro release assays. The effect of AuNPs on MET release was evaluated using UV–Vis and Laser-Induced Breakdown Spectroscopy (LIBS) techniques. AuNPs synthesized by Turkevich and Frens method resulted in a spherical shape with diameters of 34.8 ± 5.5 nm. We verified that there was no emergence or disappearance of new vibrational bands. Qualitatively and quantitatively, we showed that the MET crystals dispersed throughout the NRL. The Young's modulus and elongation values at dressing rupture were in the range appropriate for human skin application. 64.70% of the AuNP-MET complex was released within 100 h, exhibiting a second-order exponential release profile. The LIBS technique allowed monitoring of the AuNP release, indicating the Au emission peak reduction at 267.57 nm over time. Moreover, the dressing displayed an excellent hemocompatibility and fibroblast cell viability. These results demonstrated that the AuNP-MET-NRL wound dressing is a promising approach for dermal applications.
• Imprenta:
  • Publisher: Elsevier
  • Date published: 2022
• Source:
  • Título: International journal of biological macromolecules
  • ISSN: 01418130
  • Volume/Número/Paginação/Ano: v.211, p.568-579, 2022

Informações sobre o DOI: 10.1016/j.ijbiomac.2022.05.025 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

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How to cite

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• ABNT

  BORGES, Felipe Azevedo et al. Metronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing. International journal of biological macromolecules, v. 211, p. 568-579, 2022Tradução . . Disponível em: https://doi.org/10.1016/j.ijbiomac.2022.05.025. Acesso em: 27 dez. 2025.

• APA

  Borges, F. A., Morais, C. P. de, Marangoni, B. S., Nicolodelli, G., Mecwan, M., Mandal, K., et al. (2022). Metronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing. International journal of biological macromolecules, 211, 568-579. doi:10.1016/j.ijbiomac.2022.05.025

• NLM

  Borges FA, Morais CP de, Marangoni BS, Nicolodelli G, Mecwan M, Mandal K, Guerra NB, Menegatti CR, Herculano RD, Drago B de C, Baggio LO, Barros NR de, Brasil GS'AP, Scontri M, Mussagy CU, Ribeiro MCS, Milori DMBP. Metronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing [Internet]. International journal of biological macromolecules. 2022 ;211 568-579.[citado 2025 dez. 27 ] Available from: https://doi.org/10.1016/j.ijbiomac.2022.05.025

• Vancouver

  Borges FA, Morais CP de, Marangoni BS, Nicolodelli G, Mecwan M, Mandal K, Guerra NB, Menegatti CR, Herculano RD, Drago B de C, Baggio LO, Barros NR de, Brasil GS'AP, Scontri M, Mussagy CU, Ribeiro MCS, Milori DMBP. Metronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing [Internet]. International journal of biological macromolecules. 2022 ;211 568-579.[citado 2025 dez. 27 ] Available from: https://doi.org/10.1016/j.ijbiomac.2022.05.025

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