Trabalho de evento-resumo periodico

Treatment effectiveness and systemic toxicity of a tissue conditioner modified with antifungals in a rat model of denture stomatitis (2022)

• Authors:
  • Moraes, Gustavo Simão - Universidade Estadual de Ponta Grossa (UEPG)
  • Albach, Thaís - Universidade Estadual de Ponta Grossa (UEPG)
  • Sugio, Carolina Yoshi Campos
  • Cachoeira, Victoria Schlumberger
  • Kiratcz, Falyne - Universidade Estadual de Ponta Grossa (UEPG)
  • Santos, Fábio André - Universidade Estadual de Ponta Grossa (UEPG)
  • Neppelenbroek, Karin Hermana
  • Urban, Vanessa Migliorini - Universidade Estadual de Ponta Grossa (UEPG)
• USP affiliated authors: NEPPELENBROEK, KARIN HERMANA - FOB ; SUGIO, CAROLINA YOSHI CAMPOS - FOB
• Unidade: FOB
• Subjects: CLOREXIDINA; ESTOMATITE SOB PRÓTESE; REEMBASADORES DE PRÓTESE; CANDIDA ALBICANS; ANTIFÚNGICOS
• Agências de fomento:
  • Financiamento CAPES
• Language: Português
• Abstract: This study assessed the treatment effectiveness and systemic toxicity of a tissue conditioner modified with antifungals in a rat model of denture stomatitis. Healthy Wistar rats were randomly assigned to the groups: NC (negative control), SD (sterile device), DS (denture stomatitis), Soft (Softone), Nys (nystatin), Nys:βCD (nystatin:β-cyclodextrin), Chx (chlorhexidine), or Chx:βCD (chlorhexidine:βcyclodextrin). Rats of all groups, except NC and SD, wore a palatal device contaminated with Candida albicans to develop denture stomatitis. Then, rats from the Soft, Nys, Nys:βCD, Chx, and Chx:βCD groups had their devices relined with a tissue conditioner modified (or not) with antifungals at their minimum inhibitory concentrations against C. albicans. After four days, treatment effectiveness was assessed by visual analysis, CFU/mL count, histological analysis, and through myeloperoxidase (MPO) and N-acetylglucosaminidase (NAG) assays. The rats also had their blood collected for biochemical analyses and had their liver, lungs, stomach, and kidneys removed for histopathological, MPO and NAG analyses. Groups Soft, Nys, Nys:βCD, and Chx presented a significant decrease in CFU values in comparison to the DS group. All experimental groups showed lower MPO and NAG activity in the palate compared to the DS group. No relevant renal, gastric, nor pulmonary changes were noticed. The Chx group presented a significantly higher MPO activity in the liver.
• Imprenta:
  • Publisher: SBPqO
  • Publisher place: São Paulo
  • Date published: 2022
• Source:
  • Título do periódico: Brazilian Oral Research
  • ISSN: 1807-3107
  • Volume/Número/Paginação/Ano: v. 36, supl. 1, p. 25, res. HA004, 2022
• Conference titles: Proceedings of the SBPqO Annual Meeting

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• ABNT

  MORAES, Gustavo Simão et al. Treatment effectiveness and systemic toxicity of a tissue conditioner modified with antifungals in a rat model of denture stomatitis. Brazilian Oral Research. São Paulo: SBPqO. Disponível em: https://repositorio.usp.br/directbitstream/a0b80986-23ce-41fa-87fb-89a8d50987c3/3121370.pdf. Acesso em: 24 abr. 2024. , 2022

• APA

  Moraes, G. S., Albach, T., Sugio, C. Y. C., Cachoeira, V. S., Kiratcz, F., Santos, F. A., et al. (2022). Treatment effectiveness and systemic toxicity of a tissue conditioner modified with antifungals in a rat model of denture stomatitis. Brazilian Oral Research. São Paulo: SBPqO. Recuperado de https://repositorio.usp.br/directbitstream/a0b80986-23ce-41fa-87fb-89a8d50987c3/3121370.pdf

• NLM

  Moraes GS, Albach T, Sugio CYC, Cachoeira VS, Kiratcz F, Santos FA, Neppelenbroek KH, Urban VM. Treatment effectiveness and systemic toxicity of a tissue conditioner modified with antifungals in a rat model of denture stomatitis [Internet]. Brazilian Oral Research. 2022 ; 36 25.[citado 2024 abr. 24 ] Available from: https://repositorio.usp.br/directbitstream/a0b80986-23ce-41fa-87fb-89a8d50987c3/3121370.pdf

• Vancouver

  Moraes GS, Albach T, Sugio CYC, Cachoeira VS, Kiratcz F, Santos FA, Neppelenbroek KH, Urban VM. Treatment effectiveness and systemic toxicity of a tissue conditioner modified with antifungals in a rat model of denture stomatitis [Internet]. Brazilian Oral Research. 2022 ; 36 25.[citado 2024 abr. 24 ] Available from: https://repositorio.usp.br/directbitstream/a0b80986-23ce-41fa-87fb-89a8d50987c3/3121370.pdf

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