Characterization of the electrochemical behaviour of antiinflammatory and antipsychotic drugs and their interaction with biomolecules within their respective pathways (2021)
- Authors:
- Autor USP: PRATA, RAPHAEL BACIL - IQ
- Unidade: IQ
- Sigla do Departamento: QFL
- DOI: 10.11606/T.46.2021.tde-26102022-111633
- Subjects: ELETROQUÍMICA; ELETROANÁLISE
- Keywords: Anti-psicóticos atípicos; Antiinflamatórios não esteroidais; Atypical antipsychotics; Electroanalysis; Electrochemistry; Eletroanalítica; Eletroquímica; Eletroquímica molecular; Molecular electrochemistry; Nonsteroidal anti-inflammatory drugs
- Agências de fomento:
- Language: Inglês
- Abstract: In this work, divided in two parts, at first, we studied the chemical interactions of non-steroidal anti-inflammatory drugs (NSAIDs) and their target, the cicloxygenase enzyme, and secondly, the interaction between antipsychotics drugs with the catecholamine neurotransmitters, using electrochemical techniques. To achieve the prior goal, the electrochemical behaviour of dipyrone and its derivatives were studied at glassy carbon electrode, and a oxidation mechanism was proposed. Following, a cicloxygenase enzyme biosensor was developed to evaluate the anti-inflammatory properties and the pharmacological mechanism of the NSAIDs, and the interaction of the enzyme with the most used NSAIDs, dipyrone, acetil-salicylic and salycilic acid, ibuprophen, acetaminophen, and naproxen were evaluated using differential pulse voltammetry technique. The voltammetric results suggest the least and the most effective in inhibit the peroxidase active site are the acetaminophen and the ibuprophen, respectively. Whilst the electrons paramagnetic resonance suggests the enzyme oxygenase active site, are least and the most effective inhibited by the salycilic acid and the dipyrone, respectively. These results confirm the inactivation of the enzyme by a reducer, although the study with the active site and the tyrosyl radical indicate that not only the enzyme can be inactivated by a redox reaction, but also that the NSAIDs perform an allosteric regulation of the enzyme hindering its process, and consequently deactivating the arachidonic cascade. In sequence, the chemical interaction between the highly used antipsychotic drugs olanzapine and quetiapine and the catecholamine neurotransmitters were studied
- Imprenta:
- Data da defesa: 30.11.2021
- Este periódico é de acesso aberto
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: gold
- Licença: cc-by-nc-sa
-
ABNT
PRATA, Raphael Bacil. Characterization of the electrochemical behaviour of antiinflammatory and antipsychotic drugs and their interaction with biomolecules within their respective pathways. 2021. Tese (Doutorado) – Universidade de São Paulo, São Paulo, 2021. Disponível em: https://www.teses.usp.br/teses/disponiveis/46/46136/tde-26102022-111633/. Acesso em: 28 dez. 2025. -
APA
Prata, R. B. (2021). Characterization of the electrochemical behaviour of antiinflammatory and antipsychotic drugs and their interaction with biomolecules within their respective pathways (Tese (Doutorado). Universidade de São Paulo, São Paulo. Recuperado de https://www.teses.usp.br/teses/disponiveis/46/46136/tde-26102022-111633/ -
NLM
Prata RB. Characterization of the electrochemical behaviour of antiinflammatory and antipsychotic drugs and their interaction with biomolecules within their respective pathways [Internet]. 2021 ;[citado 2025 dez. 28 ] Available from: https://www.teses.usp.br/teses/disponiveis/46/46136/tde-26102022-111633/ -
Vancouver
Prata RB. Characterization of the electrochemical behaviour of antiinflammatory and antipsychotic drugs and their interaction with biomolecules within their respective pathways [Internet]. 2021 ;[citado 2025 dez. 28 ] Available from: https://www.teses.usp.br/teses/disponiveis/46/46136/tde-26102022-111633/ - Hydrogen evolution in mixed acids: a quantitative mechanistic study
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Informações sobre o DOI: 10.11606/T.46.2021.tde-26102022-111633 (Fonte: oaDOI API)
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