Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate (2022)
- Authors:
- Freire, Marjorie Caroline Liberato Cavalcanti
- Basso, Luís Guilherme Mansor
- Mendes, Luís Felipe Santos
- Mesquita, Nathalya Cristina de Moraes Roso
- Mottin, Melina
- Fernandes, Rafaela Sachetto
- Policastro, Lucca Rocha
- Godoy, Andre Schutzer de
- Santos, Igor A.
- Ruiz, Uriel Enrique Aquino
- Caruso, Icaro P.
- Sousa, Bruna K. P.
- Jardim, Ana C. G.
- Almeida, Fabio C. L.
- Gil, Laura Helena Vega Gonzales
- Andrade, Carolina H.
- Oliva, Glaucius
- Freire, Marjorie Caroline Liberato Cavalcanti
- USP affiliated authors: OLIVA, GLAUCIUS - IFSC ; FREIRE, MARJORIE CAROLINE LIBERATO CAVALCANTI - IFSC ; MENDES, LUIS FELIPE SANTOS - FFCLRP ; MESQUITA, NATHALYA CRISTINA DE MORAES ROSO - IFSC ; FERNANDES, RAFAELA SACHETTO - IFSC ; GODOY, ANDRE SCHÜTZER DE - IFSC
- Unidades: IFSC; FFCLRP
- DOI: 10.1038/s41598-022-14790-x
- Subjects: VÍRUS CHIKUNGUNYA; ESTRUTURA MOLECULAR (QUÍMICA TEÓRICA); QUÍMICA MÉDICA; RNA
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título: Scientific Reports
- ISSN: 2045-2322
- Volume/Número/Paginação/Ano: v. 12, p. 10601-1-10601-15, June 2022
- Este periódico é de acesso aberto
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: gold
- Licença: cc-by
-
ABNT
FREIRE, Marjorie Caroline Liberato Cavalcanti et al. Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate. Scientific Reports, v. 12, p. 10601-1-10601-15, 2022Tradução . . Disponível em: https://doi.org/10.1038/s41598-022-14790-x. Acesso em: 28 dez. 2025. -
APA
Freire, M. C. L. C., Basso, L. G. M., Mendes, L. F. S., Mesquita, N. C. de M. R., Mottin, M., Fernandes, R. S., et al. (2022). Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate. Scientific Reports, 12, 10601-1-10601-15. doi:10.1038/s41598-022-14790-x -
NLM
Freire MCLC, Basso LGM, Mendes LFS, Mesquita NC de MR, Mottin M, Fernandes RS, Policastro LR, Godoy AS de, Santos IA, Ruiz UEA, Caruso IP, Sousa BKP, Jardim ACG, Almeida FCL, Gil LHVG, Andrade CH, Oliva G. Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate [Internet]. Scientific Reports. 2022 ; 12 10601-1-10601-15.[citado 2025 dez. 28 ] Available from: https://doi.org/10.1038/s41598-022-14790-x -
Vancouver
Freire MCLC, Basso LGM, Mendes LFS, Mesquita NC de MR, Mottin M, Fernandes RS, Policastro LR, Godoy AS de, Santos IA, Ruiz UEA, Caruso IP, Sousa BKP, Jardim ACG, Almeida FCL, Gil LHVG, Andrade CH, Oliva G. Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate [Internet]. Scientific Reports. 2022 ; 12 10601-1-10601-15.[citado 2025 dez. 28 ] Available from: https://doi.org/10.1038/s41598-022-14790-x - Imidazonaphthyridine effects on Chikungunya virus replication: antiviral activity by dependent and independent of interferon type 1 pathways
- Biophysical characterization of the RNA-dependent RNA polimerase (nsP4) protein of Chikungunya virus
- Insights into the role of the cobalt(III)-thiosemicarbazone complex as a potential inhibitor of the Chikungunya virus nsP4
- The protein disulfide isomerase inhibitor 3-methyltoxoflavin inhibits Chikungunya virus
- Reporter replicon systems for the screening of potential antiviral agents against zika, yellow fever and chikungunya viruses
- The Antifungal itraconazole is a potent inhibitor of Chikungunya virus replication
- Reporter replicons for antiviral drug discovery against positive single-stranded RNA viruses
- Naphthyridine-derived compound effectively inhibits the early stages of CHIKV virus infection in vitro
- Caracterização estrutural da proteína nsP4 RNA polimerase RNA-dependente do vírus Chikungunya e busca por agentes antivirais
- The GA-hecate peptide inhibits the ZIKV replicative cycle in different steps and can inhibit the flavivirus NS2B-NS3 protease after cell infection
Informações sobre o DOI: 10.1038/s41598-022-14790-x (Fonte: oaDOI API)
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