Phosphodiesterase 4 inhibition restrains muscle proteolysis in diabetic rats by activating PKA and EPAC/Akt effectors and inhibiting FoxO factors (2021)
- Authors:
- USP affiliated authors: ZANON, NEUSA MARIA - FMRP ; NAVEGANTES, LUIZ CARLOS CARVALHO - FMRP ; KETTELHUT, ISIS DO CARMO - FMRP
- Unidade: FMRP
- DOI: 10.1016/j.lfs.2021.119563
- Subjects: ANTIDEPRESSIVOS; MÚSCULO ESQUELÉTICO; METABOLISMO DE PROTEÍNA; PROTEÍNAS DO TECIDO NERVOSO; TRANSDUÇÃO DE SINAL CELULAR
- Keywords: Diabetes mellitus; Proteolysis; Rolipram; Skeletal muscle; Ubiquitin-proteasome system
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher place: Philadelphia
- Date published: 2021
- Source:
- Título: Life Sciences
- ISSN: 0024-3205
- Volume/Número/Paginação/Ano: v. 278, art. 119563, p. 1-12, 2021
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
-
ABNT
ARCARO, Carlos Alberto et al. Phosphodiesterase 4 inhibition restrains muscle proteolysis in diabetic rats by activating PKA and EPAC/Akt effectors and inhibiting FoxO factors. Life Sciences, v. 278, p. 1-12, 2021Tradução . . Disponível em: https://doi.org/10.1016/j.lfs.2021.119563. Acesso em: 10 jan. 2026. -
APA
Arcaro, C. A., Assis, R. P., Oliveira, J. O., Zanon, N. M., Paula-Gomes, S., Navegantes, L. C. C., et al. (2021). Phosphodiesterase 4 inhibition restrains muscle proteolysis in diabetic rats by activating PKA and EPAC/Akt effectors and inhibiting FoxO factors. Life Sciences, 278, 1-12. doi:10.1016/j.lfs.2021.119563 -
NLM
Arcaro CA, Assis RP, Oliveira JO, Zanon NM, Paula-Gomes S, Navegantes LCC, Kettelhut I do C, Brunetti IL, Baviera AM. Phosphodiesterase 4 inhibition restrains muscle proteolysis in diabetic rats by activating PKA and EPAC/Akt effectors and inhibiting FoxO factors [Internet]. Life Sciences. 2021 ; 278 1-12.[citado 2026 jan. 10 ] Available from: https://doi.org/10.1016/j.lfs.2021.119563 -
Vancouver
Arcaro CA, Assis RP, Oliveira JO, Zanon NM, Paula-Gomes S, Navegantes LCC, Kettelhut I do C, Brunetti IL, Baviera AM. Phosphodiesterase 4 inhibition restrains muscle proteolysis in diabetic rats by activating PKA and EPAC/Akt effectors and inhibiting FoxO factors [Internet]. Life Sciences. 2021 ; 278 1-12.[citado 2026 jan. 10 ] Available from: https://doi.org/10.1016/j.lfs.2021.119563 - Efeito da peçonha de bothrops Jararaca no metabolismo protéico em músculos esqueléticos de ratos
- Adrenodemedullation activates the Ca2+-dependent proteolysis in soleus muscles from rats exposed to cold
- Calcitonin gene-related peptide inhibits autophagic-lysosomal proteolysis through cAMP/PKA signaling in rat skeletal muscles
- Insulin deficiency induces heart atrophy by activation of lysosomal and ubiquitin-proteasome proteolytic pathways in rats
- Differences in antiproteolytic response to ''beta'IND.2'-adrenergic agonist in white and red skeletal muscles
- O AMPC, via AKT/FOXO, reduz a expressão gênica da atrogin e da atividade proteolítica ubiquitina-proteassoma no músculo esquelético de ratos
- Catecholamines control the lysosomal proteolytic process in rat cardiac muscle
- Involvement of cAMP/Epac/PI3K-dependent pathway in the antiproteolytic effect epinephrine on rat skeletal muscle
- Acute cold exposure increases proteolysis but does not change the rates of protein synthesis in skeletal muscles of rats
- 'beta IND.2'-adrenergic agonists reactivate ERK1/2 and Akt signaling and supress atrophic genes in skeletal muscles from fasted mice
Informações sobre o DOI: 10.1016/j.lfs.2021.119563 (Fonte: oaDOI API)
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