The renoprotective effects of Heme Oxygenase-1 during contrast-induced acute kidney injury in preclinical diabetic models (2021)
- Authors:
- Autor USP: VATTIMO, MARIA DE FATIMA FERNANDES - EE
- Unidade: EE
- Sigla do Departamento: ENC
- DOI: 10.6061/clinics/2021/e3002
- Subjects: ESTRESSE OXIDATIVO; DIABETES MELLITUS; CONTRASTE; NEFROPATIAS
- Language: Inglês
- Abstract: OBJECTIVES: Contrast-induced acute kidney injury (CI-AKI) is an important clinical problem that can be aggravated by diabetes mellitus, a major risk factor. However, heme oxygenase-1 (HO-1), a promising therapeutic target, can exert antioxidant effects against CI-AKI. Thus, we investigated the role of HO-1 in CI-AKI in the presence of diabetes mellitus. METHODS: Twenty-eight male Wistar rats weighing 250–300g were subjected to left uninephrectomy, and concomitantly, diabetes induced by streptozotocin (65 mg/kg). After 12 weeks, iodinated contrast (meglumine ioxithalamate, 6 mL/kg) and hemin (HO-1 inducer-10 mg/k) were administered 60 min before iodinated contrast treatment. The rats were randomly divided into four groups: control, diabetes mellitus (DM), DM iodinated contrast (DMIC), and DMIC hemin (DMICH). Kidney function, albuminuria, oxidative profile, and histology were assessed. All experimental data were subjected to statistical analyses. RESULTS: CI-AKI in preclinical diabetic models decreased creatinine clearance and increased urinary neutrophil gelatinase-associated lipocalin (NGAL) levels and the degree of albuminuria. Additionally, the levels of oxidative and nitrosative stress metabolites (urinary peroxides, thiobarbituric acid-reactive substances, and NO) were elevated, while thiol levels in kidney tissue were reduced. Kidney histology showed tubular cell vacuolization and edema. HO-1 inducer treatment improved kidney function and reduced urinary the NGAL levels. The oxidative profile showed an increase in the endogenous thiol-based antioxidant levels. Additionally, the tubular injury score was reduced following HO-1 treatment. CONCLUSIONS: Our findings highlight the renoprotective effects of HO-1 in CI-AKI and preclinical diabetic models. Therefore, HO-1 ameliorates kidney dysfunction, reduces oxidative stress, and prevents cell necrosis
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Status: Artigo publicado em periódico de acesso aberto (Gold Open Access) -
ABNT
FONSECA, Cassiane Dezoti da et al. The renoprotective effects of Heme Oxygenase-1 during contrast-induced acute kidney injury in preclinical diabetic models. Clinics, v. 76, 2021Tradução . . Disponível em: https://doi.org/10.6061/clinics/2021/e3002. Acesso em: 15 mar. 2026. -
APA
Fonseca, C. D. da, Watanabe, M., Couto, S. M. F., Santos, A. A. C. dos, Borges, F. T., & Vattimo, M. de F. F. (2021). The renoprotective effects of Heme Oxygenase-1 during contrast-induced acute kidney injury in preclinical diabetic models. Clinics, 76. doi:10.6061/clinics/2021/e3002 -
NLM
Fonseca CD da, Watanabe M, Couto SMF, Santos AAC dos, Borges FT, Vattimo M de FF. The renoprotective effects of Heme Oxygenase-1 during contrast-induced acute kidney injury in preclinical diabetic models [Internet]. Clinics. 2021 ; 76[citado 2026 mar. 15 ] Available from: https://doi.org/10.6061/clinics/2021/e3002 -
Vancouver
Fonseca CD da, Watanabe M, Couto SMF, Santos AAC dos, Borges FT, Vattimo M de FF. The renoprotective effects of Heme Oxygenase-1 during contrast-induced acute kidney injury in preclinical diabetic models [Internet]. Clinics. 2021 ; 76[citado 2026 mar. 15 ] Available from: https://doi.org/10.6061/clinics/2021/e3002 - Uso da Dopamina na Insuficiencia Renal Aguda em pacientes criticos: valor terapeutico ?
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