Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCy as an analgesic drug target (2022)
- Authors:
- Moraes, Beatriz Caroline de
- Ribeiro Filho, Helder Veras
- Roldão, Allan Pradelli
- Toniolo, Elaine Flamia
- Carretero, Gustavo Penteado Battesini
- Sgro, Germán Gustavo
- Batista, Fernanda A. H
- Berardi, Damian E
- Oliveira, Victoria Regina da Silva
- Tomasin, Rebeka
- Vieceli, Felipe Monteleone
- Pramio, Dimitrius Tansini
- Bruni-Cardoso, Alexandre
- Figueira, Ana C. M
- Farah, Chuck Shaker
- Devi, Lakshmi A.
- Dale, Camila Squarzoni
- Oliveira, Paulo S. L. de
- Schechtman, Deborah
- Moraes, Beatriz Caroline de
- USP affiliated authors: SGRO, GERMÁN GUSTAVO - FCFRP ; CARDOSO, ALEXANDRE BRUNI - IQ ; FARAH, SHAKER CHUCK - IQ ; DALE, CAMILA SQUARZONI - ICB ; SCHECHTMAN, DEBORAH - IQ ; MORAES, BEATRIZ CAROLINE DE - IQ ; ROLDÃO, ALLAN PRADELLI - IQ ; CARRETERO, GUSTAVO PENTEADO BATTESINI - IQ ; OLIVEIRA, VICTORIA REGINA DA SILVA - ICB ; TOMASIN, REBEKA - IQ ; VIECELI, FELIPE MONTELEONE - IQ ; TONIOLO, ELAINE FLAMIA - ICB
- Unidades: FCFRP; IQ; ICB
- DOI: 10.1126/scisignal.abm6046
- Subjects: DOR CRÔNICA; ANALGÉSICOS; ANATOMIA; FOSFOLIPASES; MUTAÇÃO GENÉTICA
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Publisher place: Washington
- Date published: 2022
- Source:
- Título: Science Signaling
- ISSN: 1945-0877
- Volume/Número/Paginação/Ano: v. 15, n. 731, p. 1-16, 2022
- Este periódico é de assinatura
- Este artigo NÃO é de acesso aberto
- Cor do Acesso Aberto: closed
-
ABNT
MORAES, Beatriz Caroline de et al. Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCy as an analgesic drug target. Science Signaling, v. 15, n. 731, p. 1-16, 2022Tradução . . Disponível em: https://doi.org/10.1126/scisignal.abm6046. Acesso em: 26 dez. 2025. -
APA
Moraes, B. C. de, Ribeiro Filho, H. V., Roldão, A. P., Toniolo, E. F., Carretero, G. P. B., Sgro, G. G., et al. (2022). Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCy as an analgesic drug target. Science Signaling, 15( 731), 1-16. doi:10.1126/scisignal.abm6046 -
NLM
Moraes BC de, Ribeiro Filho HV, Roldão AP, Toniolo EF, Carretero GPB, Sgro GG, Batista FAH, Berardi DE, Oliveira VR da S, Tomasin R, Vieceli FM, Pramio DT, Bruni-Cardoso A, Figueira ACM, Farah CS, Devi LA, Dale CS, Oliveira PSL de, Schechtman D. Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCy as an analgesic drug target [Internet]. Science Signaling. 2022 ; 15( 731): 1-16.[citado 2025 dez. 26 ] Available from: https://doi.org/10.1126/scisignal.abm6046 -
Vancouver
Moraes BC de, Ribeiro Filho HV, Roldão AP, Toniolo EF, Carretero GPB, Sgro GG, Batista FAH, Berardi DE, Oliveira VR da S, Tomasin R, Vieceli FM, Pramio DT, Bruni-Cardoso A, Figueira ACM, Farah CS, Devi LA, Dale CS, Oliveira PSL de, Schechtman D. Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCy as an analgesic drug target [Internet]. Science Signaling. 2022 ; 15( 731): 1-16.[citado 2025 dez. 26 ] Available from: https://doi.org/10.1126/scisignal.abm6046 - New analgesic lead developed based on analysis of mutations in patients with congenital insensitivity to pain
- Structure-activity analysis of the TrkA - PLCγ interaction and the development of inhibitors that play an analgesic role based on such interaction
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Informações sobre o DOI: 10.1126/scisignal.abm6046 (Fonte: oaDOI API)
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