A microtomographic and histological analysis of the induced orthodontic movement in obese rats (2021)
- Authors:
- Autor USP: CONSOLARO, ALBERTO - FOB
- Unidade: FOB
- Subjects: OBESIDADE; MOVIMENTOS ORTODÔNTICOS; RATOS WISTAR; MICROTOMOGRAFIA
- Agências de fomento:
- Language: Inglês
- Abstract: To evaluate the effect of obesity over induced tooth movement (ITM) through computerized microtomography and histological analyzes in obesity-induced Wistar rats. Forty rats of approximately 125 g were randomly assigned into four groups according to obesity status and ITM duration (mesial movement of the left maxillary first molar for seven and fourteen days). Eighty hemi-maxillas were processed for histological and micro-CT examination. ITM was measured in the micro-CTs. The number of osteoclasts was analyzed through staining of enzyme tartrate-resistant acid phosphatase. Also, the presence or absence of focal hyalinization (FH), frontal bone resorption (FBR), and active root resorption (ARRC) were evaluated in sections stained with Hematoxylin-Eosin. Data were submitted to appropriate statistical analysis using Graph Pad Prism 5.0 and Stata13 (α=0.05) Obese animals showed higher rates of ITM after seven (p=0.037) and fourteen days (p≤0.001) than non-obese animals. A higher quantity of osteoclast was observed after seven days of ITM in obese animals (p=0.043). Low frequencies of FH were observed after seven days of ITM. After seven days of ITM high frequency of FBR and low frequency of ARRC were found in obese animals, while, medium frequencies of FBR and ARRC were seen in non-obese animals. Low and medium frequencies of FBR were observed in nonobese and obese animals respectively after fourteen days of ITM. Obese rats showed significantly higher rates of molar movement and different morphological responses in the surrounding bone and periodontium to ITM.
- Imprenta:
- Source:
- Título: Brazilian Oral Research
- Volume/Número/Paginação/Ano: 1807-3107
- Conference titles: Sociedade Brasileira de Pesquisa Odontológica - SBPqO - Virtual Annual Meeting
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ABNT
HORTA, K. C. et al. A microtomographic and histological analysis of the induced orthodontic movement in obese rats. Brazilian Oral Research. São Paulo: Faculdade de Odontologia de Bauru, Universidade de São Paulo. . Acesso em: 25 jan. 2026. , 2021 -
APA
Horta, K. C., Paula-Silva, F. W. G., Stuani, M. B. S., Elias, L. L. K., Flores Mir, C., Graf, D., et al. (2021). A microtomographic and histological analysis of the induced orthodontic movement in obese rats. Brazilian Oral Research. São Paulo: Faculdade de Odontologia de Bauru, Universidade de São Paulo. -
NLM
Horta KC, Paula-Silva FWG, Stuani MBS, Elias LLK, Flores Mir C, Graf D, Consolaro A, Matsumoto MAN. A microtomographic and histological analysis of the induced orthodontic movement in obese rats. Brazilian Oral Research. 2021 ;[citado 2026 jan. 25 ] -
Vancouver
Horta KC, Paula-Silva FWG, Stuani MBS, Elias LLK, Flores Mir C, Graf D, Consolaro A, Matsumoto MAN. A microtomographic and histological analysis of the induced orthodontic movement in obese rats. Brazilian Oral Research. 2021 ;[citado 2026 jan. 25 ] - Neurilemoma no palato duro: relato de caso clínico
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