Artigo de periodico

Associations among osteocalcin, leptin and metabolic health in children ages 9–13 years in the United States (2017)

• Authors:
  • Giudici, Kelly Virecoulon
  • Kindler, Joseph M
  • Martin, Berdine R
  • McCabe, George P
  • McCabe, Linda D
  • Laing, Emma M
  • Hausman, Dorothy B
  • Martini, Lígia Araújo
  • Lewis, Richard D
  • Weaver, Connie M
  • Peacock, Munro
  • Gallant, Kathleen M. Hill
• USP affiliated authors: CAVALHEIRO, LIGIA ARAUJO MARTINI - FSP ; GIUDICI, KELLY VIRECOULON - FSP
• Unidade: FSP
• DOI: 10.1186/s12986-017-0171-9
• Subjects: CRIANÇAS; OSTEOBLASTO; LEPTINA; OBESIDADE; GLICOSE; INSULINA; ESTADOS UNIDOS
• Agências de fomento:
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
    Processo FAPESP: 2013/15823-2
• Language: Inglês
• Abstract: Background:This study aimed to investigate the relationships among osteocalcin, leptin and metabolic healthoutcomes in children ages 9–13 years.Methods:This was a cross-sectional analysis of baseline data from 161 boys and 157 girls (ages 9–13 years) whopreviously participated in a double-blinded randomized placebo controlled trial of vitamin D supplementation.Relationships among fasting serum total osteocalcin (tOC), undercarboxylated osteocalcin (ucOC), leptin, andmetabolic health outcomes were analyzed.Results:Approximately 52% of study participants were obese based on percent body fat cutoffs (>25% for boysand >32% for girls) and about 5% had fasting serum glucose within the prediabetic range (i.e. 100 to 125 mg/dL).Serum tOC was not correlated with leptin, glucose, insulin, HOMA-IR, or HOMA-βafter adjusting for percent body fat.However, serum ucOC negatively correlated with leptin (partial r =−0.16;p= 0.04) and glucose (partial r =−0.16;p=0.04)after adjustment for percent body fat. Leptin was a positive predictor of insulin, glucose, HOMA-IR, and HOMA-βafteradjusting for age, sex and percent body fat (allp<0.001).Conclusions:These data depict an inverse relationship between leptin and various metabolic health outcomes inchildren. However, the notion that tOC or ucOC link fat withenergy metabolism in healthy children was not supported.Clinical trial registration number:NCT00931580
• Imprenta:
  • Publisher place: Londres
  • Date published: 2017
• Source:
  • Título do periódico: Nutrition & Metabolism
  • ISSN: 1743-7075
  • Volume/Número/Paginação/Ano: v.14, [9p.], 2017

Informações sobre o DOI: 10.1186/s12986-017-0171-9 (Fonte: oaDOI API)
• Este periódico é de acesso aberto
• Este artigo é de acesso aberto
• URL de acesso aberto
• Cor do Acesso Aberto: gold
• Licença: cc-by

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• ABNT

  GIUDICI, Kelly Virecoulon et al. Associations among osteocalcin, leptin and metabolic health in children ages 9–13 years in the United States. Nutrition & Metabolism, v. 14, p. [9], 2017Tradução . . Disponível em: https://doi.org/10.1186/s12986-017-0171-9. Acesso em: 18 set. 2024.

• APA

  Giudici, K. V., Kindler, J. M., Martin, B. R., McCabe, G. P., McCabe, L. D., Laing, E. M., et al. (2017). Associations among osteocalcin, leptin and metabolic health in children ages 9–13 years in the United States. Nutrition & Metabolism, 14, [9]. doi:10.1186/s12986-017-0171-9

• NLM

  Giudici KV, Kindler JM, Martin BR, McCabe GP, McCabe LD, Laing EM, Hausman DB, Martini LA, Lewis RD, Weaver CM, Peacock M, Gallant KMH. Associations among osteocalcin, leptin and metabolic health in children ages 9–13 years in the United States [Internet]. Nutrition & Metabolism. 2017 ;14 [9].[citado 2024 set. 18 ] Available from: https://doi.org/10.1186/s12986-017-0171-9

• Vancouver

  Giudici KV, Kindler JM, Martin BR, McCabe GP, McCabe LD, Laing EM, Hausman DB, Martini LA, Lewis RD, Weaver CM, Peacock M, Gallant KMH. Associations among osteocalcin, leptin and metabolic health in children ages 9–13 years in the United States [Internet]. Nutrition & Metabolism. 2017 ;14 [9].[citado 2024 set. 18 ] Available from: https://doi.org/10.1186/s12986-017-0171-9

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