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Artigo de periodico

Glutamine: metabolism and immune function, supplementation and clinical translation (2018)

  • Authors:
  • Autor USP: ROGERO, MARCELO MACEDO - FSP
  • Unidade: FSP
  • DOI: 10.3390/nu10111564
  • Subjects: GLUTAMINA; METABOLISMO; IMUNIDADE; SUPLEMENTAÇÃO ALIMENTAR
  • Language: Inglês
  • Abstract: Abstract: Glutamine is the most abundant and versatile amino acid in the body. In health and disease, the rate of glutamine consumption by immune cells is similar or greater than glucose. For instance, in vitro and in vivo studies have determined that glutamine is an essential nutrient for lymphocyte proliferation and cytokine production, macrophage phagocytic plus secretory activities, and neutrophil bacterial killing. Glutamine release to the circulation and availability is mainly controlled by key metabolic organs, such as the gut, liver, and skeletal muscles. During catabolic/hypercatabolic situations glutamine can become essential for metabolic function, but its availabilitymaybecompromisedduetotheimpairmentofhomeostasisintheinter-tissuemetabolism of amino acids. For this reason, glutamine is currently part of clinical nutrition supplementation protocols and/or recommended for immune suppressed individuals. However, in a wide range of catabolic/hypercatabolic situations (e.g., ill/critically ill, post-trauma, sepsis, exhausted athletes), it is currently difficult to determine whether glutamine supplementation (oral/enteral or parenteral) should be recommended based on the amino acid plasma/bloodstream concentration (also known as glutaminemia). Although the beneficial immune-based effects of glutamine supplementation are already established, many questions and evidence for positive in vivo outcomes still remain to be presented. Therefore, this paper provides an integrated review of how glutamine metabolism in key organs is important to cells of the immune system. We also discuss glutamine metabolism and action, and important issues related to the effects of glutamine supplementation in catabolic situations
  • Imprenta:
  • Source:
    • Título: Nutrients
    • ISSN: 2072-6643
    • Volume/Número/Paginação/Ano: v.10, n.11, art. 1564 [31p.]
    • Acesso à fonteDOI
    Informações sobre o DOI: 10.3390/nu10111564 (Fonte: oaDOI API)
    • Este periódico é de acesso aberto
    • Este artigo NÃO é de acesso aberto
    How to cite
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    • ABNT

      CRUZAT, Vinicius Fernandes et al. Glutamine: metabolism and immune function, supplementation and clinical translation. Nutrients, v. 10, n. 11, p. art. 1564 [31], 2018Tradução . . Disponível em: https://doi.org/10.3390/nu10111564. Acesso em: 06 fev. 2026.

    • APA

      Cruzat, V. F., Rogero, M. M., Keane, K. N., Curi, R., & Newsholme, P. (2018). Glutamine: metabolism and immune function, supplementation and clinical translation. Nutrients, 10( 11), art. 1564 [31]. doi:10.3390/nu10111564

    • NLM

      Cruzat VF, Rogero MM, Keane KN, Curi R, Newsholme P. Glutamine: metabolism and immune function, supplementation and clinical translation [Internet]. Nutrients. 2018 ;10( 11): art. 1564 [31].[citado 2026 fev. 06 ] Available from: https://doi.org/10.3390/nu10111564

    • Vancouver

      Cruzat VF, Rogero MM, Keane KN, Curi R, Newsholme P. Glutamine: metabolism and immune function, supplementation and clinical translation [Internet]. Nutrients. 2018 ;10( 11): art. 1564 [31].[citado 2026 fev. 06 ] Available from: https://doi.org/10.3390/nu10111564

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