Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium (2018)
- Authors:
- Leoncini, Emanuele
- Moyses, Raquel Ajub
- Matsuo, Keitaro
- Bosetti, Cristina
- La Vecchia, Carlo
- Serraino, Diego
- Simonato, Lorenzo
- Merletti, Franco
- Boffetta, Paolo
- Hashibe, Mia
- Lee, Yuan-Chin Amy
- Vukovic, Vladimir
- Boccia, Stefania
- Cadoni, Gabriella
- Giraldi, Luca
- Pastorino, Roberta
- Arzani, Dario
- Petrelli, Livia
- Wünsch Filho, Victor
- Toporcov, Tatiana Natasha
- USP affiliated authors: MOYSÉS, RAQUEL AJUB - FM ; WUNSCH FILHO, VICTOR - FSP ; TOPORCOV, TATIANA NATASHA - FSP
- Unidades: FM; FSP
- DOI: 10.1007/s10654-018-0409-5
- Subjects: NEOPLASIAS DE CABEÇA E PESCOÇO; MODO DE VIDA; REINCIDÊNCIA; ESTUDOS MULTICÊNTRICOS
- Agências de fomento:
- Language: Inglês
- Abstract: Recurrence and second primary cancer (SPC) continue to represent major obstacles to long-term survival in head and neckcancer (HNC). Our aim was to evaluate whether established demographics, lifestyle-related risk factors for HNC andclinical data are associated with recurrence and SPC in HNC. We conducted a multicentre study by using data from fivestudies members of the International Head and Neck Cancer Epidemiology consortium—Milan, Rome, Western Europe,Sao Paulo, and Japan, totalling 4005 HNC cases with a median age of 59 (interquartile range 52–67). Multivariate hazardratios (HRs) and 95% confidence intervals (CIs) were estimated for recurrence and SPC. During follow-up, 1161 (29%)patients had recurrence and 343 (8.6%) developed SPC. Advanced tumour stage was associated with increased risk ofrecurrence in HNC overall (HR = 1.76, 95% CI 1.41–2.19). Women with laryngeal cancer had a reduced risk of recurrencecompared to men (HR = 0.39, 95% CI: 0.24–0.74). Concerning predictors of SPC, advanced age (HR = 1.02; 95% CI:1.00–1.04) and alcohol consumption ([1 drink per day, HR = 2.11; 95% CI: 1.13–3.94) increased the risk of SPC amongpatients with laryngeal cancer. Additionally, women were at higher risk of SPC, in HNC overall group (HR = 1.68; 95%CI: 1.13–2.51) and oropharyngeal cancer group (HR = 1.74; 95% CI: 1.02–2.98). Tumour stage and male gender (larynxonly) were positive predictors of cancer recurrence in HNC patients. Predictors of SPC were advanced age and alcohol useamong laryngeal cancer cases, and female gender for oropharyngeal and HNC overall
- Imprenta:
- Source:
- Título: European Journal of Epidemiology
- ISSN: 0393-2990
- Volume/Número/Paginação/Ano: v.33, p. 1205-1218, 2018
- Este periódico é de assinatura
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: hybrid
- Licença: cc-by
-
ABNT
LEONCINI, Emanuele et al. Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium. European Journal of Epidemiology, v. 33, p. 1205-1218, 2018Tradução . . Disponível em: https://doi.org/10.1007/s10654-018-0409-5. Acesso em: 30 dez. 2025. -
APA
Leoncini, E., Moyses, R. A., Matsuo, K., Bosetti, C., La Vecchia, C., Serraino, D., et al. (2018). Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium. European Journal of Epidemiology, 33, 1205-1218. doi:10.1007/s10654-018-0409-5 -
NLM
Leoncini E, Moyses RA, Matsuo K, Bosetti C, La Vecchia C, Serraino D, Simonato L, Merletti F, Boffetta P, Hashibe M, Lee Y-CA, Vukovic V, Boccia S, Cadoni G, Giraldi L, Pastorino R, Arzani D, Petrelli L, Wünsch Filho V, Toporcov TN. Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium [Internet]. European Journal of Epidemiology. 2018 ;33 1205-1218.[citado 2025 dez. 30 ] Available from: https://doi.org/10.1007/s10654-018-0409-5 -
Vancouver
Leoncini E, Moyses RA, Matsuo K, Bosetti C, La Vecchia C, Serraino D, Simonato L, Merletti F, Boffetta P, Hashibe M, Lee Y-CA, Vukovic V, Boccia S, Cadoni G, Giraldi L, Pastorino R, Arzani D, Petrelli L, Wünsch Filho V, Toporcov TN. Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium [Internet]. European Journal of Epidemiology. 2018 ;33 1205-1218.[citado 2025 dez. 30 ] Available from: https://doi.org/10.1007/s10654-018-0409-5 - Estudo epidemiológico ecológico
- Risco relativo e "Odds Ratio": razão de chances
- Epidemiological science and cancer control
- Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach
- Estudo epidemiológico transversal ou de prevalência
- Coorte e estudos de coortes
- IARC (International Agency for Research on Cancer)
- Incidência e seus indicadores
- Letalidade e seus indicadores
- Estudo epidemiológico longitudinal do tipo "caso x controle"
Informações sobre o DOI: 10.1007/s10654-018-0409-5 (Fonte: oaDOI API)
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