Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? (2018)
- Authors:
- USP affiliated authors: JATENE, FABIO BISCEGLI - FM ; FERNANDES, PAULO MANUEL PEGO - FM
- Unidade: FM
- DOI: 10.1590/S1806-37562017000000172
- Subjects: PNEUMONIA; TRANSPLANTE DE PULMÃO; AZUL DE METILENO
- Language: Português
- Abstract: Objective: To evaluate whether methylene blue (MB) could minimize the effects of ischemia-reperfusion injury in the nonischemic lung on a lung transplantation rodent model. Methods: Forty female Sprague-Dawley rats were divided into 20 donors and 20 recipients. The 20 recipient rats were divided into two groups (n = 10) according to the treatment (0.9% saline vs. 1% MB solutions). All animals underwent unilateral lung transplantation. Recipients received 2 mL of saline or MB intraperitoneally prior to transplantation. After 2 h of reperfusion, the animals were euthanized and histopathological and immunohistochemical analyses were performed in the nonischemic lung. Results: There was a significant decrease in inflammation-neutrophil count and intercellular adhesion molecule-1 (ICAM-1) expression in lung parenchyma were higher in the saline group in comparison with the MB group-and in apoptosis-caspase-3 expression was higher in the saline group and Bcl-2 expression was higher in MB group. Conclusions: MB is an effective drug for the protection of nonischemic lungs against inflammation and apoptosis following unilateral lung transplantation in rats
- Imprenta:
- Publisher place: Brasilia Df
- Date published: 2018
- Source:
- Título: Jornal brasileiro de pneumologia
- ISSN: 1806-3713
- Volume/Número/Paginação/Ano: v. 44, n. 5, p. 378-382, 2018
- Este periódico é de acesso aberto
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: gold
- Licença: cc-by-nc
-
ABNT
ABREU, Marcus da Matta et al. Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation?. Jornal brasileiro de pneumologia, v. 44, n. 5, p. 378-382, 2018Tradução . . Disponível em: https://doi.org/10.1590/S1806-37562017000000172. Acesso em: 03 out. 2024. -
APA
Abreu, M. da M., Almeida, F. M. de, Santos, K. B. dos, Assis, E. A. C. P. de, Hamada, R. K. F., Jatene, F. B., et al. (2018). Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? Jornal brasileiro de pneumologia, 44( 5), 378-382. doi:10.1590/S1806-37562017000000172 -
NLM
Abreu M da M, Almeida FM de, Santos KB dos, Assis EACP de, Hamada RKF, Jatene FB, Fernandes PMP, Pazetti R. Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? [Internet]. Jornal brasileiro de pneumologia. 2018 ; 44( 5): 378-382.[citado 2024 out. 03 ] Available from: https://doi.org/10.1590/S1806-37562017000000172 -
Vancouver
Abreu M da M, Almeida FM de, Santos KB dos, Assis EACP de, Hamada RKF, Jatene FB, Fernandes PMP, Pazetti R. Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? [Internet]. Jornal brasileiro de pneumologia. 2018 ; 44( 5): 378-382.[citado 2024 out. 03 ] Available from: https://doi.org/10.1590/S1806-37562017000000172 - Tumores carcinóides: resultados do tratamento operatório
- Doenças da aorta
- Redução volumétrica pós-transplante pulmonar unilateral para tratamento de hiperinsuflação enfisematosa do pulmão nativo: relato de dois casos
- Effects of mycophenolate sodium on mucociliary clearance using a bronchial section and anastomosis rodent model
- Impact of topically-applied preservation solutions on mucociliary clearance and trachel ischemic injury in rats
- Tratamento da pneumopatia avançada
- Tratamento cirúrgico das pneumopatias avaçadas
- Tratamento de complicações brônquicas após transplante pulmonar
- Dupla troca valvar por disfunção secundária a tumor carcinoide
- Recondicionamento pulmonar ex vivo: uma nova era para o transplante pulmonar
Informações sobre o DOI: 10.1590/S1806-37562017000000172 (Fonte: oaDOI API)
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas