Artigo de periodico

Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? (2018)

• Authors:
  • Abreu, Marcus da Matta
  • Almeida, Francine Maria de
  • Santos, Kelli Borges dos
  • Assis, Emilio Augusto Campos Pereira de
  • Hamada, Rafael Kenji Fonseca
  • Jatene, Fabio Biscegli
  • Fernandes, Paulo Manuel Pego
  • Pazetti, Rogerio
• USP affiliated authors: JATENE, FABIO BISCEGLI - FM ; FERNANDES, PAULO MANUEL PEGO - FM
• Unidade: FM
• DOI: 10.1590/S1806-37562017000000172
• Subjects: PNEUMONIA; TRANSPLANTE DE PULMÃO; AZUL DE METILENO
• Language: Português
• Abstract: Objective: To evaluate whether methylene blue (MB) could minimize the effects of ischemia-reperfusion injury in the nonischemic lung on a lung transplantation rodent model. Methods: Forty female Sprague-Dawley rats were divided into 20 donors and 20 recipients. The 20 recipient rats were divided into two groups (n = 10) according to the treatment (0.9% saline vs. 1% MB solutions). All animals underwent unilateral lung transplantation. Recipients received 2 mL of saline or MB intraperitoneally prior to transplantation. After 2 h of reperfusion, the animals were euthanized and histopathological and immunohistochemical analyses were performed in the nonischemic lung. Results: There was a significant decrease in inflammation-neutrophil count and intercellular adhesion molecule-1 (ICAM-1) expression in lung parenchyma were higher in the saline group in comparison with the MB group-and in apoptosis-caspase-3 expression was higher in the saline group and Bcl-2 expression was higher in MB group. Conclusions: MB is an effective drug for the protection of nonischemic lungs against inflammation and apoptosis following unilateral lung transplantation in rats
• Imprenta:
  • Publisher place: Brasilia Df
  • Date published: 2018
• Source:
  • Título do periódico: Jornal brasileiro de pneumologia
  • ISSN: 1806-3713
  • Volume/Número/Paginação/Ano: v. 44, n. 5, p. 378-382, 2018

Informações sobre o DOI: 10.1590/S1806-37562017000000172 (Fonte: oaDOI API)
• Este periódico é de acesso aberto
• Este artigo é de acesso aberto
• URL de acesso aberto
• Cor do Acesso Aberto: gold
• Licença: cc-by-nc

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How to cite

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• ABNT

  ABREU, Marcus da Matta et al. Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation?. Jornal brasileiro de pneumologia, v. 44, n. 5, p. 378-382, 2018Tradução . . Disponível em: https://doi.org/10.1590/S1806-37562017000000172. Acesso em: 23 abr. 2024.

• APA

  Abreu, M. da M., Almeida, F. M. de, Santos, K. B. dos, Assis, E. A. C. P. de, Hamada, R. K. F., Jatene, F. B., et al. (2018). Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? Jornal brasileiro de pneumologia, 44( 5), 378-382. doi:10.1590/S1806-37562017000000172

• NLM

  Abreu M da M, Almeida FM de, Santos KB dos, Assis EACP de, Hamada RKF, Jatene FB, Fernandes PMP, Pazetti R. Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? [Internet]. Jornal brasileiro de pneumologia. 2018 ; 44( 5): 378-382.[citado 2024 abr. 23 ] Available from: https://doi.org/10.1590/S1806-37562017000000172

• Vancouver

  Abreu M da M, Almeida FM de, Santos KB dos, Assis EACP de, Hamada RKF, Jatene FB, Fernandes PMP, Pazetti R. Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation? [Internet]. Jornal brasileiro de pneumologia. 2018 ; 44( 5): 378-382.[citado 2024 abr. 23 ] Available from: https://doi.org/10.1590/S1806-37562017000000172

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