Artigo de periodico

Factors associated with brain volume in major depression in older adults without dementia: results from a large autopsy study (2017)

• Authors:
  • Nunes, Paula Villela
  • Suemoto, Claudia Kimie
  • Leite, Renata Elaine Paraizo
  • Ferretti-Rebustini, Renata Eloah de Lucena
  • Pasqualucci, Carlos Augusto Gonçalves
  • Nitrini, Ricardo
  • Farfel, José Marcelo
  • Oliveira, Kátia Cristina de
  • Grinberg, Lea Tenenholz
  • Costa, Nicole Rezende da
  • Nascimento, Camila Fernandes
  • Salmasi, Faraz
  • Kim, Helena Kyunghee
  • Young, Lionel Trevor
  • Jacob Filho, Wilson
  • Lafer, Beny
• USP affiliated authors: SUEMOTO, CLAUDIA KIMIE - FM ; FERRETTI-REBUSTINI, RENATA ELOAH DE LUCENA - EE ; PASQUALUCCI, CARLOS AUGUSTO GONCALVES - FM ; NITRINI, RICARDO - FM ; FARFEL, JOSÉ MARCELO - FM ; GRINBERG, LEA TENENHOLZ - FM ; LAFER, BENY - FM
• Unidades: FM; EE
• Sigla do Departamento: MCM
• DOI: 10.1002/gps.4649
• Subjects: DEPRESSÃO; IDOSOS; HIPERTENSÃO; AUTÓPSIA; DIABETES MELLITUS
• Language: Inglês
• Abstract: Objective: We examined brain volume and atrophy in individuals with major depressive disorder (MDD) without dementia that were referred to a large autopsy service. We also examined potential risk factors for brain atrophy, including demographics and clinical variables. Methods:In this study, 1373 participants (787 male) aged 50 years or older who died from natural causes were included. Participants with no reliable informant, with cognitive impairment or dementia, with a medical history of severe chronic disease, or with prolonged agonal state were excluded. Presence of MDD at least once in their lifetime was defined according to the Structured Clinical Interview for DSM. Brain volume was measured immediately after removal from the skull. Results: Mean age at death was 68.6 11.6, and MDD was present in 185 (14%) individuals. Smaller brain volume was associated with older age (p<0.001), lower education (years; p<0.001), hypertension (p= 0.001), diabetes (p= 0.006), and female gender (p<0.001). In the multivariate analysis adjusted for sociodemographics and cardiovascular risk factors, smaller brain volume was not associated with major depression (β=0.86, 95% CI =26.50 to 24.77, p= 0.95). Conclusions: In this large autopsy study of older adults, MDD was not associated with smaller brain volumes. Regardless of the presence of MDD, in this sample of older adults without dementia, we found that smaller brain volumes were associated with risk factors for brain neurodegeneration such as older age, diabetes, hypertension, and lower education
• Imprenta:
  • Publisher place: Chichester
  • Date published: 2017
• Source:
  • Título: International Journal of Geriatric Psychiatry
  • ISSN: 0885-6230
  • Volume/Número/Paginação/Ano: v.1, p.[1]-7, Jan. 2017

Informações sobre o DOI: 10.1002/gps.4649 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

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• ABNT

  NUNES, Paula Villela et al. Factors associated with brain volume in major depression in older adults without dementia: results from a large autopsy study. International Journal of Geriatric Psychiatry, v. 1, n. Ja 2017, p. [1]-7, 2017Tradução . . Disponível em: https://doi.org/10.1002/gps.4649. Acesso em: 29 dez. 2025.

• APA

  Nunes, P. V., Suemoto, C. K., Leite, R. E. P., Ferretti-Rebustini, R. E. de L., Pasqualucci, C. A. G., Nitrini, R., et al. (2017). Factors associated with brain volume in major depression in older adults without dementia: results from a large autopsy study. International Journal of Geriatric Psychiatry, 1( Ja 2017), [1]-7. doi:10.1002/gps.4649

• NLM

  Nunes PV, Suemoto CK, Leite REP, Ferretti-Rebustini RE de L, Pasqualucci CAG, Nitrini R, Farfel JM, Oliveira KC de, Grinberg LT, Costa NR da, Nascimento CF, Salmasi F, Kim HK, Young LT, Jacob Filho W, Lafer B. Factors associated with brain volume in major depression in older adults without dementia: results from a large autopsy study [Internet]. International Journal of Geriatric Psychiatry. 2017 ;1( Ja 2017): [1]-7.[citado 2025 dez. 29 ] Available from: https://doi.org/10.1002/gps.4649

• Vancouver

  Nunes PV, Suemoto CK, Leite REP, Ferretti-Rebustini RE de L, Pasqualucci CAG, Nitrini R, Farfel JM, Oliveira KC de, Grinberg LT, Costa NR da, Nascimento CF, Salmasi F, Kim HK, Young LT, Jacob Filho W, Lafer B. Factors associated with brain volume in major depression in older adults without dementia: results from a large autopsy study [Internet]. International Journal of Geriatric Psychiatry. 2017 ;1( Ja 2017): [1]-7.[citado 2025 dez. 29 ] Available from: https://doi.org/10.1002/gps.4649

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