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Combination of stem cells from deciduous teeth and electroacupuncture in dogs with chronic spinal cord injury (2016)

  • Authors:
  • Autor USP: PRADO, CéSAR VINICIUS GIL BRAZ DO - FMVZ
  • Unidade: FMVZ
  • Sigla do Departamento: VCI
  • Subjects: CÉLULAS-TRONCO; POLPA DENTÁRIA; PARAPLÉGICO; CÃES; MEDULA ESPINHAL
  • Keywords: Cell therapy; Células-tronco de polpa de dente humano esfoliado; Complete spinal cord injury; Hérnia de disco intervertebral; Intervertebral disc herniation; Paraplegia; Paraplegy; Stem cells from exfoliated human dental pulp; Terapia Celular
  • Language: Português
  • Abstract: Previous studies have reported that combination of electroacupuncture (EA) and mesenchymal stem/stromal cells (MSC) promoted survival, differentiation and functional recovery in spinal cord-transected rats. In this study, it was examined the therapeutic effects of stem cells from canine exfoliated dental pulp (SCED) combined with EA treatment in dogs with chronic naturally occurred spinal cord injury due to intervertebral disc herniation (IVDH). Dogs were randomly assigned to four experimental groups (n=4 for each group; total of 16 animals): SCED, EA, SCED + EA) and control. Mild increase in the neurological scoring was found in one animal from SCED group (1/4; 2 points gained), one from EA group (1/4; 8 points gained), three from SCED+EA group (3/4; 16 points gained) and one from control group (1/4; 2 points gained). Functional outcome improvements were observed two animals from SCED group (2/4; 3 points gained), two from EA group (2/4; 4 points gained), one from SCED+EA group (1/4; 1 point gained) and two were from control group (2/4; 6 points gained). However no statistical differences were observed. Magnetic resonance imaging (MRI) findings did not suggest improvement comparing pre- and post-treatment within groups, excepted from one animal from SCED group (1/4), and 10 animals from all groups (10/16) presented signs of injury progression in the SCI in post-treatment exam, which could not be associated to the procedures from study, but could be related to the naturalevolution of the disease. Limitation such as number of transplanted stem cells, delivery route, injury chronicity and intrinsic variation among naturally spinal cord injured dogs could have influence outcomes negatively. Moreover, canine deciduous exfoliated teeth were easily obtained and SCED were simply isolated, and no mortality followed up 7 month from procedure were observed
  • Imprenta:
  • Data da defesa: 20.12.2016
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    • ABNT

      PRADO, César Vinicius Gil Braz do; MIGLINO, Maria Angélica. Combination of stem cells from deciduous teeth and electroacupuncture in dogs with chronic spinal cord injury. 2016.Universidade de São Paulo, São Paulo, 2016. Disponível em: < http://www.teses.usp.br/teses/disponiveis/10/10132/tde-21032017-162328/ >.
    • APA

      Prado, C. V. G. B. do, & Miglino, M. A. (2016). Combination of stem cells from deciduous teeth and electroacupuncture in dogs with chronic spinal cord injury. Universidade de São Paulo, São Paulo. Recuperado de http://www.teses.usp.br/teses/disponiveis/10/10132/tde-21032017-162328/
    • NLM

      Prado CVGB do, Miglino MA. Combination of stem cells from deciduous teeth and electroacupuncture in dogs with chronic spinal cord injury [Internet]. 2016 ;Available from: http://www.teses.usp.br/teses/disponiveis/10/10132/tde-21032017-162328/
    • Vancouver

      Prado CVGB do, Miglino MA. Combination of stem cells from deciduous teeth and electroacupuncture in dogs with chronic spinal cord injury [Internet]. 2016 ;Available from: http://www.teses.usp.br/teses/disponiveis/10/10132/tde-21032017-162328/

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