Cost-effectiveness analysis of routine rotavirus vaccination in Brazil (2008)
- Authors:
- Autor USP: NOVAES, HILLEGONDA MARIA DUTILH - FM
- Unidade: FM
- DOI: 10.1590/S1020-49892008000400001
- Subjects: ROTAVÍRUS (IMUNOLOGIA); VACINAS VIRAIS; BRASIL
- Language: Português
- Abstract: Objective. The objective of this study was to conduct a cost-effectiveness analysis of a universal rotavirus vaccination program among children ≤ 5 years of age in Brazil. Methods. Considering a hypothetical annual cohort of approximately 3 300 000 newborns followed over 5 years, a decision-tree model was constructed to examine the possible clinical and economic effects of rotavirus infection with and without routine vaccination of children. Probabilities and unit costs were derived from published research and national administrative data. The impact of different estimates for key parameters was studied using sensitivity analysis. The analysis was conducted from both healthcare system and societal perspectives. Results. The vaccination program was estimated to prevent approximately 1 735 351 (54%) of the 3 210 361 cases of rotavirus gastroenteritis and 703 (75%) of 933 rotavirus-associated deaths during the 5-year period. At a vaccine price of 18.6 Brazilian reais (R$) per dose, this program would cost R$121 673 966 and would save R$38 536 514 in direct costs to the public healthcare system and R$71 778 377 in direct and indirect costs to society. The program was estimated to cost R$1 028 and R$1 713 per life-years saved (LYS) from the societal and healthcare system perspectives, respectively. Conclusions. Universal rotavirus vaccination was a cost-effective strategy for both perspectives. However, these findings are highly sensitive to diarrhea incidence rate, proportion of severe cases, vaccine coverage, and vaccine price.
- Imprenta:
- Publisher place: Washington
- Date published: 2008
- Source:
- Título: Revista Panamericana de Salud Pública
- ISSN: 1020-4989
- Volume/Número/Paginação/Ano: v. 24, n. 4, p. 221-230, 2008
- Este periódico é de acesso aberto
- Este artigo NÃO é de acesso aberto
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ABNT
SOÁREZ, Patrícia Coelho de et al. Cost-effectiveness analysis of routine rotavirus vaccination in Brazil. Revista Panamericana de Salud Pública, v. 24, n. 4, p. 221-230, 2008Tradução . . Disponível em: https://doi.org/10.1590/S1020-49892008000400001. Acesso em: 06 fev. 2026. -
APA
Soárez, P. C. de, Novaes, H. M. D., Valentim, J., & Sartori, A. M. C. (2008). Cost-effectiveness analysis of routine rotavirus vaccination in Brazil. Revista Panamericana de Salud Pública, 24( 4), 221-230. doi:10.1590/S1020-49892008000400001 -
NLM
Soárez PC de, Novaes HMD, Valentim J, Sartori AMC. Cost-effectiveness analysis of routine rotavirus vaccination in Brazil [Internet]. Revista Panamericana de Salud Pública. 2008 ; 24( 4): 221-230.[citado 2026 fev. 06 ] Available from: https://doi.org/10.1590/S1020-49892008000400001 -
Vancouver
Soárez PC de, Novaes HMD, Valentim J, Sartori AMC. Cost-effectiveness analysis of routine rotavirus vaccination in Brazil [Internet]. Revista Panamericana de Salud Pública. 2008 ; 24( 4): 221-230.[citado 2026 fev. 06 ] Available from: https://doi.org/10.1590/S1020-49892008000400001 - Vacinas, soros e imunizações no Brasil [Resenha]
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Informações sobre o DOI: 10.1590/S1020-49892008000400001 (Fonte: oaDOI API)
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